Journals / Erciyes Tıp Dergisi / 2013 / Cilt: 35 - Sayı: 3

Pediatrik vakalarda travmatik beyin hasarı sonrası akut dönemde TSH ve ACTH hormon düzeylerinin değerlendirilmesi

Evaluation of TSH and ACTH hormone levels during the acute phase after traumatic brain Injury in pediatric cases

Pages
128–131
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Early diagnosis of the existence of such critical conditions, particularly adrenal deficiency, may be life-saving.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Head trauma is a clinical condition including a number of conditions, ranging from scalp injury to severe brain damage.
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Key Findings & Data:Materials and Methods: The study includes 30 TBI cases ad- mitted to the Neurosurgery Intensive Care Unit.
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Conclusion & Impact:Early diagnosis of the existence of such critical conditions, particularly adrenal deficiency, may be life-saving.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Head trauma is a clinical condition including a number of conditions, ranging from scalp injury to severe brain damage. In various adult studies, it was shown that pituitary dysfunction may develop in the acute phase after traumatic brain injury (TBI). However, in pediatric cases, there are few studies on this issue. This study aims to examine the effects of acute TBI on the HPA axis and thyroid axis during the pediatric period. Materials and Methods: The study includes 30 TBI cases ad- mitted to the Neurosurgery Intensive Care Unit. Trauma severity was measured by GCS. In the first 24 hours, blood samples were taken to measure basal hormone levels (TSH, T3, T4, ACTH and Cortisol). Results: In 7 (23.3%) out of 30 cases ACTH deficiency; in 4 (13.3%) cases TSH deficiency and in 11 cases (36.6%) eu- thyroid-sick syndrome was found. There was no correlation between the trauma severity and hormonal deficiency, but a positive correlation was present between ACTH and Cortisol. Conclusion: This study showed that, in children admitted due to head trauma, pituitary hormonal dysfunction might develop in the acute phase after TBI. Early diagnosis of the existence of such critical conditions, particularly adrenal deficiency, may be life-saving.

Özet

Amaç: Kafa travması saçlı deri yaralanmalarından, yaygın beyin hasarına kadar bir çok durumu içine alan klinik bir durumdur. Kafa Travması sonrası erişkin hastalarda yapılan çeşitli çalışmalarda hipofiz yetmezliğinin gelişebileceği gösterilmiştir. Ancak pediatrik yaş grubunda yeterli veri yoktur. Akut dönemde gelişecek Hipotalamo-Hipofizo-Adrenal Aks (HPA aks) ve tiroid aks hasarı hastalarda adrenal yetmezlik ve hipotiroidiye sebep olmaktadır. Bu çalışmanın amacı; çocukluk yaş grubunda kafa travmasının akut dönemde HPA aks üzerine ve tiroid aksı üzerine etkilerini incelemektir. Gereç ve Yöntemler: Kafa travması sonrası Beyin Cerrahisi Kliniği yoğun bakımına yatırılan 30 hasta çalışmaya dahil edildi. Travma şiddeti Glaskow Koma Skalasına (GKS) göre değerlendirildi. İlk 24 saat içersinde bazal hormon ölçümleri için kan örnekleri alındı (TSH, T3, T4, ACTH ve Kortizol). Bulgular: Çalışmaya dahil edilen 30 hastadan 7’sinde (%23,3) Kortizol eksikliği, 4’ünde (%13,3) santal hipotiroidi ve 11’inde (%36,6) hasta ötiroid sendromu tespit edildi. Travma şiddeti ile hormon eksiklikleri arasında korelasyon saptanmadı. Kortizol ile ACTH arasında pozitif korelasyon tespit edildi. Sonuç: Bu çalışmada, TBH nedeniyle hastaneye başvuran çocuklarda, akut dönemde hipofiz hormon fonksiyonlarının değerlendirilmesinin önemli olduğu gösterilmiştir. Özellikle adrenal yetmezlik gibi kritik durumların varlığının erken teşhisi ve uygun tedavisi hayat kurtarıcı olabilmektedir.

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Cite This Article

ULUTABANCA, H., KÜÇÜK, A., HATİPOĞLU, N., KARACA, Z., SELÇUKLU, A., KURTOĞLU, S., KELEŞTİMUR, F. (2022). Pediatrik vakalarda travmatik beyin hasarı sonrası akut dönemde TSH ve ACTH hormon düzeylerinin değerlendirilmesi. Erciyes Tıp Dergisi, Cilt: 35 - Sayı: 3, 128–131. https://ajindex.com/articles/502415

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