AI Summary & Key Takeaways
AI InsightThere was a statistically significant relationship between the HBV DNA level at the time of treatment initiation and the response to treatment (p
📌 3 Key Takeaways
Abstract
Objective: In this study, we aimed to retrospectively evaluate patients in terms of the treatment applied to them, their responses to treatment, factors affecting the response to treatment and complications of the disease. Materials and Methods: A total of 89 patients included in the study were divided into five groups: those carrying hepatitis B virus, those receiving interferon treatment (IFN), those receiving lavumidin treatment (LAM), those receiving lavumidin and interferon treatment (IFN+LAM), and those with chronic hepatitis B but not receiving any medical treatment for this disease. Results: The rate of full viral clearance was 6.7%. The full response rate was 53.8% in the IFN group, 39.3% in the LAM group, and 29.4% in the IFN+LAM group. There was a statistically significant relationship between the HBV DNA level at the time of treatment initiation and the response to treatment (p
Özet
Amaç: Kronik Hepatit B infeksiyonu tanısı ile tedavisiz en az beş yıl veya tedavi verildikten sonra en az iki yıl süreyle izlen- miş olan hastaların aldıkları tedavi, tedaviye yanıtları, tedaviye yanıtta etkili olan faktörler ve hastalığın komplikasyonları yönünden retrospektif olarak değerlendirilmesi amaçlandı. Gereç ve Yöntemler: Çalışmaya alınan toplam 89 hasta; hepatit B taşıyıcısı, kronik B hepatitli interferon tedavisi alanlar, kronik B hepatitli lamuvidin tedavisi alanlar, kronik B hepatitli interferon ve lamuvidin tedavisi alanlar, kronik B hepatitli teda- vi almayanlar olarak 5 guruba ayrıldı. Bulgular: Tam viral klirens oranı %6,7 idi. Tam yanıt oranı IFN grubunda %53,8, LAM grubunda %39,3, IFN+LAM grubunda %29,4 idi. Başvuru anında HBV DNA düzeyi ile tedaviye yanıt arasında istatistiksel ilişki vardı (p