SavedAdd your journal

Journals / Erciyes Medical Journal / 2020 / Cilt: 42 - Sayı: 4

High Mobility Group Box – 1 in Patients with Bacterial Septic Arthritis of the Knee: A Controlled Prospective Study

Halis Atıl ATİLLA
Alper ÖZTÜRK
Ali YALÇINDAĞ
Yenel Gürkan BİLGETEKİN
Mesut EMLEK
Önder ERSAN
Esra ÇETİN
Pages
463–467
Publication Date
2022-10-11
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Although HMGB1 may predict articular damage in any form of arthritis, serum or synovial HMGB1 of patients with bacterial septic arthritis are similar to patients with non-bacterial arthritis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: High mobility group Box–1 (HMGB-1) is related to inflammation and many kinds of arthritic diseases.
📊
Key Findings & Data:In this study, we aimed to find out if serum or synovial HMGB1 can be used for diagnosis and differentiation of septic arthritis.
💡
Conclusion & Impact:Conclusion: Although HMGB1 may predict articular damage in any form of arthritis, serum or synovial HMGB1 of patients with bacterial septic arthritis are similar to patients with non-bacterial arthritis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: High mobility group Box–1 (HMGB-1) is related to inflammation and many kinds of arthritic diseases. Septic arthritis is acute infectious arthritis with potentially devastating outcomes and needs to be diagnosed and treated in an emergent manner. It is not always easy to distinguish septic arthritis from other forms of acute arthritis. In this study, we aimed to find out if serum or synovial HMGB1 can be used for diagnosis and differentiation of septic arthritis. Materials and Methods: Consecutive patients who were admitted to the emergency department with suspected knee septic arthritis were included in this study. Patients were divided into two groups as septic and non-septic arthritis regarding Newman’s criteria. All patients underwent a laboratory analysis of serum and synovial fluid for white blood cell count, c-reactive protein, sedimentation, cultures, and HMGB1. Results: There were 23 patients with acute bacterial septic arthritis and 21 with acute non-bacterial arthritis. No difference was observed regarding age and sex. In the septic group, serum WBC, body temperature, sedimentation, CRP and synovial WBC were significantly higher. However, no difference was observed between groups regarding serum and synovial HMGB1 levels. Conclusion: Although HMGB1 may predict articular damage in any form of arthritis, serum or synovial HMGB1 of patients with bacterial septic arthritis are similar to patients with non-bacterial arthritis.

🔖

Cite This Article

ATİLLA, H. A., ÖZTÜRK, A., YALÇINDAĞ, A., BİLGETEKİN, Y. G., EMLEK, M., ERSAN, Ö., ÇETİN, E. (2022). High Mobility Group Box – 1 in Patients with Bacterial Septic Arthritis of the Knee: A Controlled Prospective Study. Erciyes Medical Journal, Cilt: 42 - Sayı: 4, 463–467. https://ajindex.com/articles/502314

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Ross JJ. Septic Arthritis of Native Joints. Infect Dis Clin North Am 2017; 31(2): 203–18
  2. Simkin PA. The human knee: A window on the microvasculature. Tissue Barriers 2015; 3(1-2): e970465
  3. Li SF, Henderson J, Dickman E, Darzynkiewicz R. Laboratory tests in adults with monoarticular arthritis: can they rule out a septic joint?. Acad Emerg Med 2004; 11(3): 276–80
  4. Pellegrini L, Foglio E, Pontemezzo E, Germani A, Russo MA, Limana F. HMGB1 and repair: focus on the heart. Pharmacol Ther 2019; 196: 160–82
  5. Andersson U, Yang H, Harris H. Extracellular HMGB1 as a therapeutic target in inflammatory diseases. Expert Opin Ther Targets 2018; 22(3): 263–77
  6. Li ZC, Cheng GQ, Hu KZ, Li MQ, Zang WP, Dong YQ, et al. Correlation of synovial fluid HMGB-1 levels with radiographic severity of knee osteoarthritis. Clin Invest Med 2011; 34(5): E298
  7. Andersson U, Erlandsson-Harris H. HMGB1 is a potent trigger of arthritis. J Intern Med 2004; 255(3): 344–50
  8. Taniguchi N, Kawakami Y, Maruyama I, Lotz M. HMGB proteins and arthritis. Hum Cell 2018; 31(1): 1–9
  9. Newman JH. Review of septic arthritis throughout the antibiotic era. Ann Rheum Dis 1976; 35(3): 198–205
  10. Long B, Koyfman A, Gottlieb M. Evaluation and Management of Septic Arthritis and its Mimics in the Emergency Department. West J Emerg Med 2019; 20(2): 331–41
  11. Deng M, Scott MJ, Fan J, Billiar TR. Location is the key to function: HMGB1 in sepsis and trauma-induced inflammation. J Leukoc Biol 2019; 106(1): 161–9
  12. Heinola T, Kouri VP, Clarijs P, Ciferska H, Sukura A, Salo J, et al. High mobility group box-1 (HMGB-1) in osteoarthritic cartilage. Clin Exp Rheumatol 2010; 28(4): 511–8
  13. Pullerits R, Schierbeck H, Uibo K, Liivamägi H, Tarraste S, Talvik T, et al. High mobility group box protein 1—A prognostic marker for structural joint damage in 10-year follow-up of patients with juvenile idiopathic arthritis. Semin. Arthritis Rheum 2017; 46(4): 444–50
  14. Amini M, Pakdaman A, Shapoori S, Mosayebi G. High Mobility Group box-1 (HMGB1) Protein As a Biomarker for Acute Cholecystitis. Rep Biochem Mol Biol 2019; 7(2): 204–9
  15. Yang R, Zou X, Tenhunen J, Tønnessen TI. HMGB1 and Extracellular Histones Significantly Contribute to Systemic Inflammation and Multiple Organ Failure in Acute Liver Failure. Mediators Inflamm 2017; 2017: 5928078
  16. Meng L, Li L, Lu S, Li K, Su Z, Wang Y, et al. The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4