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Journals / Erciyes Medical Journal / 2021 / Cilt: 43 - Sayı: 2

Protective Effect of Indole-3-Carbinol on SpermMorphometric Alteration in a High-Fat Diet-InducedObese Rat Model

Nur Hande TÜFEK
Ahmad YAHYAZADEH
Pages
161–165
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Our finding showed an increased abnormal morphology in sperms due to the detrimental effect of obesity.Also, the administration of I3C may have improved such sperm abnormalities and, thus, infertility in obese rats.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: This study aimed to investigate the deleterious effect of obesity induced by high-fat diet on rat testes.
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Key Findings & Data:Anotherobjective was to survey the possible efficacy of indole-3-carbinol (I3C) on testicular change in obese rats.
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Conclusion & Impact:Conclusion: Our finding showed an increased abnormal morphology in sperms due to the detrimental effect of obesity.Also, the administration of I3C may have improved such sperm abnormalities and, thus, infertility in obese rats.
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: This study aimed to investigate the deleterious effect of obesity induced by high-fat diet on rat testes. Anotherobjective was to survey the possible efficacy of indole-3-carbinol (I3C) on testicular change in obese rats. Materials and Methods: Twenty-four rats were randomly assigned into 4 groups as follows: control, obese, indole-3- carbinol (I3C), and obese+I3C groups. Morphometric and histopathological examination was performed on sperm smears todetermine the type and percentage of abnormalities in sperm morphology. Results: We found a significant decrease in the percentage of sperms with normal morphology in the obese group in com parison with the control group. Moreover, the percentage of abnormal sperm head, neck, and tail was significantly increasedin the obese group compared with that in the control group. In the obese+I3C group, the percentage of normal spermmorphology was significantly higher than that in the obese group, but the percentage of abnormal sperm heads, necks, andtails decreased. Morphological examination also exhibited various types of abnormalities in the sperm heads, necks, and tails. Conclusion: Our finding showed an increased abnormal morphology in sperms due to the detrimental effect of obesity.Also, the administration of I3C may have improved such sperm abnormalities and, thus, infertility in obese rats.

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Cite This Article

TÜFEK, N. H., YAHYAZADEH, A. (2022). Protective Effect of Indole-3-Carbinol on SpermMorphometric Alteration in a High-Fat Diet-InducedObese Rat Model. Erciyes Medical Journal, Cilt: 43 - Sayı: 2, 161–165. https://ajindex.com/articles/502221

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References (12)

  1. Hruby A, Hu FB. The Epidemiology of Obesity: A Big Picture. Pharmacoeconomics 2015; 33(7): 673–89
  2. Yamawaki Y, Oue K, Shirawachi S, Asano S, Harada K, Kanematsu T. Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation. Jpn Dent Sci Rev 2017; 53(1): 18–24
  3. Wright N, Wilson L, Smith M, Duncan B, McHugh P. The BROAD study: A randomised controlled trial using a whole food plant-based diet in the community for obesity, ischaemic heart disease or diabetes. Nutr Diabetes 2017; 7(3): e256
  4. Huo L, Su Y, Xu G, Zhai L, Zhao J. Sulforaphane Protects the Male Reproductive System of Mice from Obesity-Induced Damage: Involvement of Oxidative Stress and Autophagy. Int J Environ Res Public Health 2019; 16(19): 3759
  5. Luo Q, Li Y, Huang C, Cheng D, Ma W, Xia Y, et al. Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway. Molecules 2019; 24(16): 2966
  6. Jarukamjorn K, Jearapong N, Pimson C, Chatuphonprasert W. A HighFat, High-Fructose Diet Induces Antioxidant Imbalance and Increases the Risk and Progression of Nonalcoholic Fatty Liver Disease in Mice. Scientifica (Cairo) 2016; 2016: 5029414
  7. Ye J, Luo D, Xu X, Sun M, Su X, Tian Z, et al. Metformin Improves Fertility in Obese Males by Alleviating Oxidative Stress-Induced Blood-Testis Barrier Damage. Oxid Med Cell Longev 2019; 2019: 9151067
  8. Suleiman JB, Nna VU, Zakaria Z, Othman ZA, Bakar ABA, Mohamed M. Obesity-induced testicular oxidative stress, inflammation and apoptosis: Protective and therapeutic effects of orlistat. Reprod Toxicol 2020; 95: 113–22
  9. Wang SQ, Cheng LS, Liu Y, Wang JY, Jiang W. Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection. Curr Drug Metab 2016; 17(4): 401–9
  10. Safa M, Jafari L, Alikarami F, Manafi Shabestari R, Kazemi A. Indole3-carbinol induces apoptosis of chronic myelogenous leukemia cells through suppression of STAT5 and Akt signaling pathways. Tumour Biol 2017; 39(6): 1010428317705768
  11. Choi Y, Kim Y, Park S, Lee KW, Park T. Indole-3-carbinol prevents diet-induced obesity through modulation of multiple genes related to adipogenesis, thermogenesis or inflammation in the visceral adipose tissue of mice. J Nutr Biochem 2012; 23(12): 1732–9
  12. Alkan I, Altunkaynak BZ, Altun G, Erener E. The investigation of the effects of topiramate on the hypothalamic levels of fat mass/obesity-associate