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Journals / Erciyes Medical Journal / 2021 / Cilt: 43 - Sayı: 2

Correlation Between Androgen Levels and DryEye Parameters in Male Patients with ChronicObstructive Pulmonary Disease

Koray GÜMÜŞ
İnci GÜLMEZ
Duygu Gülmez SEVİM
Metin ÜNLÜ
Pages
194–200
Publication Date
2022-10-11
DOI
—
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Results: Patients with COPD had lower levels of circulating androgens, decreased TF-BUT, and lower Schirmer scoreand greater LG staining score, MGD grade, and MG area loss than healthy controls (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To investigate the effects of chronic obstructive pulmonary disease (COPD) in the dry eye status in men and todetermine whether the hypoandrogenic status has any concomitant impact.
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Key Findings & Data:Materials and Methods: We enrolled 80 patients with stable COPD and healthy volunteers individually matched on the ba sis of body mass index (BMI), age, and sex.
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Conclusion & Impact:Results: Patients with COPD had lower levels of circulating androgens, decreased TF-BUT, and lower Schirmer scoreand greater LG staining score, MGD grade, and MG area loss than healthy controls (p
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: To investigate the effects of chronic obstructive pulmonary disease (COPD) in the dry eye status in men and todetermine whether the hypoandrogenic status has any concomitant impact. Materials and Methods: We enrolled 80 patients with stable COPD and healthy volunteers individually matched on the ba sis of body mass index (BMI), age, and sex. Ocular surface testing included ocular surface disease index (OSDI) questionnaire,evaluation of meibomian gland dysfunction (MGD), tear fluorescein break-up time (TF-BUT), ocular surface staining withlissamine green (LG), Schirmer test with topical anesthesia, and Sirius meibographic analysis of meibomian gland area (MGA)loss. Bioavailable testosterone and free testosterone were measured using the measured total testosterone (TT), albumin, andsex hormone binding globulin (SHBG) levels. Results: Patients with COPD had lower levels of circulating androgens, decreased TF-BUT, and lower Schirmer scoreand greater LG staining score, MGD grade, and MG area loss than healthy controls (p

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Cite This Article

GÜMÜŞ, K., GÜLMEZ, İ., SEVİM, D. G., ÜNLÜ, M. (2022). Correlation Between Androgen Levels and DryEye Parameters in Male Patients with ChronicObstructive Pulmonary Disease. Erciyes Medical Journal, Cilt: 43 - Sayı: 2, 194–200. https://ajindex.com/articles/502220

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References (14)

  1. Gibson EJ, Bucknall MP, Golebiowski B, Stapleton F. Comparative limitations and benefits of liquid chromatography - mass spectrometry techniques for analysis of sex steroids in tears. Exp Eye Res 2019; 179: 168–78
  2. Sullivan DA, Rocha EM, Aragona P, Clayton JA, Ding J, Golebiowski B, et al. TFOS DEWS II Sex, Gender, and Hormones Report. Ocul Surf 2017; 15(3): 284–333
  3. Sullivan DA, Bélanger A, Cermak JM, Bérubé R, Papas AS, Sullivan RM, et al. Are women with Sjögren’s syndrome androgen-deficient? J Rheumatol 2003; 30(11): 2413–9
  4. Sullivan DA. Tearful relationships? Sex, hormones, the lacrimal gland, and aqueous-deficient dry eye. Ocul Surf 2004; 2(2): 92–123
  5. Gagliano C, Caruso S, Napolitano G, Malaguarnera G, Cicinelli MV, Amato R, et al. Low levels of 17-β-oestradiol, oestrone and testosterone correlate with severe evaporative dysfunctional tear syndrome in postmenopausal women: a case-control study. Br J Ophthalmol 2014; 98(3): 371–6
  6. Craig JP, Nichols KK, Akpek EK, Caffery B, Dua HS, Joo CK, et al. TFOS DEWS II Definition and Classification Report. Ocul Surf 2017; 15(3): 276–83
  7. Svartberg J. Androgens and chronic obstructive pulmonary disease. Curr Opin Endocrinol Diabetes Obes 2010; 17(3): 257–61
  8. Araujo AB, O’Donnell AB, Brambilla DJ, Simpson WB, Longcope C, Matsumoto AM, et al. Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 2004; 89(12): 5920–6
  9. Balasubramanian V, Naing S. Hypogonadism in chronic obstructive pulmonary disease: incidence and effects. Curr Opin Pulm Med 2012; 18(2): 112–7
  10. Van Vliet M, Spruit MA, Verleden G, Kasran A, Van Herck E, Pitta F, et al. Hypogonadism, quadriceps weakness, and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005; 172(9): 1105–11
  11. Vogelmeier CF, Criner GJ, Martinez FJ, Anzueto A, Barnes PJ, Bourbeau J, et al. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary. Am J Respir Crit Care Med 2017; 195(5): 557– 82
  12. Wolffsohn JS, Arita R, Chalmers R, Djalilian A, Dogru M, Dumbleton K, et al. TFOS DEWS II Diagnostic Methodology report. Ocul Surf 2017; 15(3): 539–74
  13. Meller D, Tseng SC. Conjunctivochalasis: literature review and possible pathophysiology. Surv Ophthalmol 1998; 43(3): 225–32
  14. Tomlinson A, Bron AJ, Korb DR, Amano S, Paugh JR, Pearce EI