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Journals / Erciyes Medical Journal / 2022 / Cilt: 44 - Sayı: 4

Rare Presentation of a Common Hematological Malignancy

Anirudh J. SHETTY
Sujit JANARDHANAN
Rimesh PAL
Pages
434–436
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: MSCC, although rare, can be a presenting complaint of AML resulting from cord compression due to spinal myeloid sarcoma.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: Metastatic spinal cord compression (MSCC) is a well-recognized complication of underlying malignancies; however, MSCC is rarely seen in acute leukemia.
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Key Findings & Data:Case Report: A 24-year-old female presented with low backache, right lower limb radicular pain, right foot drop, and loss of bladder sensation, suggestive of cauda conus syndrome.
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Conclusion & Impact:Conclusion: MSCC, although rare, can be a presenting complaint of AML resulting from cord compression due to spinal myeloid sarcoma.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: Metastatic spinal cord compression (MSCC) is a well-recognized complication of underlying malignancies; however, MSCC is rarely seen in acute leukemia. Case Report: A 24-year-old female presented with low backache, right lower limb radicular pain, right foot drop, and loss of bladder sensation, suggestive of cauda conus syndrome. Magnetic resonance images revealed an enhanced pre-/paravertebral lesion extending from the L5-S3 level with destruction of the vertebral body and intraspinal infiltration. A peripheral blood smear revealed atypical cells, which bone marrow analysis confirmed to be vacuolated myeloblasts. A diagnosis was made of acute myeloid leukemia (AML) type M4 with spinal myeloid sarcoma leading to cord compression. A cytarabine and doxorubicin-based chemotherapy regimen was initiated. Her symptoms improved after 2 cycles, however, she developed febrile neutropenia after 4 cycles of treatment and died. Conclusion: MSCC, although rare, can be a presenting complaint of AML resulting from cord compression due to spinal myeloid sarcoma.

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Cite This Article

SHETTY, A. J., JANARDHANAN, S., PAL, R. (2022). Rare Presentation of a Common Hematological Malignancy. Erciyes Medical Journal, Cilt: 44 - Sayı: 4, 434–436. https://ajindex.com/articles/502143

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References (7)

  1. Robson P. Metastatic spinal cord compression: a rare but important complication of cancer. Clin Med (Lond) 2014; 14(5): 542–5
  2. Loblaw DA, Laperriere NJ, Mackillop WJ. A population-based study of malignant spinal cord compression in Ontario. Clin Oncol (R Coll Radiol) 2003; 15(4): 211–7
  3. Chouchary DR, Bhattacharya M, Mishtra P, Mahapatra M, Kumar R. Granulocytic sarcoma of spine: an unusual initial presentation of acute myeloid leukemia. J Assoc Physicians India 2006; 54: 897
  4. Ghalaut PS, Jindal S, Jeewan O. Granulocytic sarcoma as initial presentation of acute myeloid leukaemia. J Assoc Physicians India 2005; 53: 828
  5. Dhakar MB, Bansal P, Tselis AC. Sacral spine myeloid sarcoma. Neurohospitalist 2016; 6(2): 87–8
  6. Smith TR, Slimack N, McClendon J Jr, Wong A, Fessler RG. Low back pain and lumbar radiculopathy as harbingers of acute myeloid leukemia recurrence in a patient with myeloid sarcoma. J Clin Neurosci 2012; 19(7): 1040–1
  7. Seok JH, Park J, Kim SK, Choi JE, Kim CC. Granulocytic sarcoma of the spine: MRI and clinical review. Am J Roentgenol 2010; 194(2): 485–9.