Diabetes mellitus and liver functions

Objective & Hypothesis:Aim: We aimed to observe abnormal liver function tests, the frequency of hepatomegaly and hepatosteatosis in diabetic patients.

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Key Findings & Data:One or more were found to be elevated in 34 (%50) patients.

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Conclusion & Impact:Results: Frequency of hepatosteatosis and hepatomegaly is increased in patients with poorly controlled and long-duration diabetes.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Aim: We aimed to observe abnormal liver function tests, the frequency of hepatomegaly and hepatosteatosis in diabetic patients. Methods: Sixty-eight consecutive diabetic patients admitting to outpatient Clinics of Endocrinology and Metabolism division Meram Medical Faculty were evaluated for liver function test abnormalities. Findings: Levels of alanine aminotranspherase, aspartate aminotranspherase, gamma glutamyl transpeptidase and alkaline phosphatase were studied. One or more were found to be elevated in 34 (%50) patients. Of these 34 cases, steatosis was diagnosed in 26 patients (76,4%) , cirrhosis in 1 (2,9%), chronic viral hepatitis in 2 (5,8%). Five patients were HbsAg positive (7,3%) and three were positive for HCV (anti HCV positive) (%4,4). Results: Frequency of hepatosteatosis and hepatomegaly is increased in patients with poorly controlled and long-duration diabetes.

Özet

Amaç: Adult Diabetes Mellituslu hastalarda anormal karaciğer fonksiyon testleri ile hepatomegali ve steatoz sıklığını araştırmayı amaçladık.. Yöntem: Selçuk Üniversitesi Meram Tıp Fakültesi Endokrinoloji polikliniğine başvuran ardışık 68 Diabetes Mellituslu hasta değerlendirmeye alındı. Bulgular: 34 hastada (%50) alanin aminotransferaz, aspartat aminotransferaz, gamaglutamil transpeptidaz ve alkalen fosfataz değerlerinden biri veya birkaçı yüksek bulundu. Bu vakaların 26'smda (%76,4) steatoz. Tinde (%2,9) siroz, 2'sinde (% 5,8) kronik viral hepatit saptandı. Sonuç: Diabetes Mellituslu hastalarda kan şekeri regülasyonu bozuksa ve hastalık 10 yılını doldurmuşsa karaciğer steatozu ve hepatomegali sıklığı artmaktadır.

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Cite This Article

KAYAÇETİN, E., KISAKOL, G., ÜNLER, K. G. (2022). Diabetes mellitus and liver functions. Endokrinolojide Yönelişler, Cilt: 11 - Sayı: 4, 157–159. https://ajindex.com/articles/500923

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