AI Summary & Key Takeaways
AI InsightIn conclusion, the prevalence of hepatitis C virus infection is low in Turkish patients with Hashimoto's thyroiditis.
📌 3 Key Takeaways
Abstract
To clarify controversies on the prevalence and clinical significance of hepatitis C virus infection in autoimmune thyroiditis. 64 patients with Hashimoto's thyroditis (6 males / 58 females: mean age 50.5±16.3 years, range 19-66) were invalved into this study. Serum thyroid hormone levels (total T3, total T4, and TSH), anti-TPO Ab were measured by immunochemiluminometric method, radioimmunoassay and radioligandassay, respectively. For hepatic function, serum activities of alkaline phosphates, gamma glutamyltransferase, and aminotransferases were measured by Technicon DAX-72 autoanalyzer. Hepatitis C virus infection was searched by a second-generation enzyme immunoassay (ELISA 2). If sample repeatedly found to be positive anti-HCV by ELISA 2, test was further examined by nested polymerase chain reaction assay for serum HCV-RNA. The patients were euthyroid (n:28; 43.8%), subclinic hypothyroid (n:8; 43.8%). The mean level of anti-thyroglobulin antibodies anti-microsomal antibodieswere elevated (314.5±75 U/ml, 4073±4748 U/ml. Respectively) Only one women (1.5%) had trully positive for hepatitis C antibodies. In conclusion, the prevalence of hepatitis C virus infection is low in Turkish patients with Hashimoto's thyroiditis.
Özet
Otoimmun tiroiditte Hepatitis C virus infeksiyonun klinik önemi ve prevalansı üzerindeki zıtlıkları açıklığa kavuşturabilmek amacıyla Hashimoto tiroiditi olan 64 hasta (6 erkek/58 kadın, ort.yas: 50.5±16.3 yıl, yaş aralığı 19-66) çalışmaya alındı. Serum tiroid hormon düzeyleri (T3, T4, Stsh, ve anti-Tg antikoru, anti-TPO antikoru sırası ile "immunochemiluminometric method, radioimmunoassay and radioligandassay" yöntemler aracılığıyla tayin edildi. Karaciğer fonksiyonu olarak serum alkali fosfatazı, amino transferazları ve gamma glutamiltransferaz Technicon DAX,-72 autoanalyzer ile tayin edildi. Hepatitis C virus infeksiyonu" a second-generation enzyme immunoassay ELISA 2" yöntemi ile bakıldı. Tekrarlayan ölçümlerde pozitiflik bulunması halinde serum, HCV-RNA tayini için "nested polymerase chain reaction assay" ile araştırıldı. Hastaların %43.8'i ötiroid, %12.5'i subklinik hipotiroidi ve %43.8'i aşikar hipotiroidi, hashimoto thyroiditis bulundu. Ortalama antitroglobulin antikoru ve antimikrozomal antikorlar yüksekti (314.5+75 U/ml ve 4073±4748 U/ml). Sadece bir kadın hastada hepatitis C antikoru pozitif sonuç verdi. Sonuçta Hepatitis C virus infeksiyon sıklığı Hashimoto tiroidit'li Türk hastalarda düşük (%1.5) bulundu