SavedAdd your journal

Journals / Endokrinolojide Yönelişler / 2004 / Cilt: 13 - Sayı: 5

Effect of thyroid dysfunctions on thrombocyte aggregation

Tiroid disfonksiyonlarının trombositlerin agregasyonu üzerine etkileri

Ayşegül UĞUR
Ahmet KAYA
Erdal KURTOĞLU
Pages
142–144
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Because thrombocyte aggregation prolonged in hypothyroidism and decreased in hyperthyroidism, we think that there is a relationship between thrombocyte aggregation and thyroid hormone levels.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Thyroid dysfunction may be seen together with hemostatic abnormalities.
📊
Key Findings & Data:In this study thrombocyte aggregation of 17 patients with hypothyroidism and 17 patients with hyperthyroidism, who were new diagnosed and were not treated previously, was measured.
💡
Conclusion & Impact:Because thrombocyte aggregation prolonged in hypothyroidism and decreased in hyperthyroidism, we think that there is a relationship between thrombocyte aggregation and thyroid hormone levels.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Thyroid dysfunction may be seen together with hemostatic abnormalities. It is known that thyroid hormones effect thrombocyte adhesion and aggregation leading to hemostatic abnormalities. In this study thrombocyte aggregation of 17 patients with hypothyroidism and 17 patients with hyperthyroidism, who were new diagnosed and were not treated previously, was measured. Results were compared to healthy controls. Thrombocyte aggregation prolonged in response to stimulation by ADP and epinephrine in patients with hypothyroidism where as it decreased in patients with hyperthyroidism (p < 0.05). Because thrombocyte aggregation prolonged in hypothyroidism and decreased in hyperthyroidism, we think that there is a relationship between thrombocyte aggregation and thyroid hormone levels.

Özet

Tiroid disfonksiyonu bazen hemostaz bozuklukları ile birlikte görülebilmektedirler. Tiroid hormonunun trombositlerin adezyon ve agregasyonunu etkilediği ve bu nedenle hemostaz bozukluklarına neden olduğu belirtilmektedir. Bu çalışmada yeni tanı almış ve tedavi uygulanmamış 17 hipotiroidi ve 17 hipertiroidili hastada trombositlerin agregasyonu ölçüldü. Sonuçlar sağlıklı kişiler ile kıyaslandı. Hipotiroidili hastalarda ADP ve epinefrin stimulasyonuna trombosit agregasyon yanıtının anlamlı olarak uzadığı (p < 0.05), hipertiroidi de ise azaldığı tespit edildi (p < 0.0-5). Hipotiroidili hastalarda trombosit agregasyonunun uzaması, hipertiroidili hastalarda ise azalmasından dolayı; trombosit agregasyonu ile tiroid hormon düzeyi arasında önemli bir ilişkinin olduğunu düşünmekteyiz.

🔖

Cite This Article

UĞUR, A., KAYA, A., KURTOĞLU, E. (2022). Effect of thyroid dysfunctions on thrombocyte aggregation. Endokrinolojide Yönelişler, Cilt: 13 - Sayı: 5, 142–144. https://ajindex.com/articles/500846

References (13)

  1. Wintrobe's Clinical Hematology. Eleventh edition. Lipincoit Williams & Wilkins, Philadelphia 2004; 662
  2. Saipov TD, Aripov DA, Khashimova KM, Abduzhamilov AA, Saatov TS. The lipid composition and aggregating capacity of thrombocytes in hyper-and hypothyroidism, Probl Endokrinol 1989; 35: 47-50
  3. Myrup B, Bregengard C, Faber J. Primary haemostasis in thyroid disease, J Intern Med 1995; 238: 59-63
  4. Aribarg A, Phupong V. Vaginal bleeding in young children. Southeast Asian J Trop Med Public Health 2003; 34: 208-12
  5. Fukunaga K. Refractory gastrointestinal bleeding treated with thyroid hormone replacement. J Clin Gastroenterol 2001; 33: 145-7
  6. Gordon CM, Austin DJ, Radovick S, Laufer MR. Primary hypothyroidim presenting as severe vaginal bleeding in a prepubertal girl.,J Pediatr Adolesc Gynecol 1997; 10: 35-8
  7. Brenner PF. Differential diagnosis of abnormal uterine bleeding. Am J Obstet Gynecol 1996; 175: 766-9
  8. Ghannam NN, Hammami MM, Muttair Z, Bakheet SM. Primaiy hypothyroidism-associated TSI -secreting pituitary adenoma/hypcrplasia presenting as a bleeding nasal mass extremely elevated TSH level, J Endocrinol Invest 1999; 22: 419-23
  9. Paul DA, Leef KH, Stefano JL, Banoshesky L Thyroid function in very- low-birth-weight infants with intraventricular hemorrhage. Clin Pediatr 2000; 39:651-6
  10. Kirichuk VP, Baluchi VP. Lukoianova Tl. Platelet dysfunction in diffuse goiter and experimental thyrotoxicosis. Probl Endokrinol 1981: 27: 20-5
  11. Marongiu F, Conti M, Mameli G, Murtas ML, Hab.ano S, Sorano G, Ma- muso AM, Martino E. Fibrinogen and fibrinolytic activity in hyperthy roidism before and after antithyroid treatment, J Endocrinol Invest 1988; 11: 723
  12. Lizurova I, Lazur J.Mosanska M, Trejbal D, Trejbalova Zemberova H, Changes in thrombocyte aggregation in primary hypothyroidism
  13. Masunaga R, Nagasaka A, Nakai A, Kontke A, Sawai V, Oda N, Moku- no T, shimazaki K, Hayakawa N. Kato R, Hirano E, Hagiwara M, Hidaka H, Alteration of platelet aggregation in patients with thyroid disorders. Metabolism 1997; 46(10): 1128-31.