Journals / Endokrinolojide Yönelişler / 2004 / Cilt: 13 - Sayı: 4

The effects of glucose metabolism disorder on the cardiovascular risk factor in the patients with hypertension

Hipertansif hastalarda glikoz metabolizma bozukluğunun kardiyovasküler risk faktörlerine etkisi

Pages
115–119
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Glucose metabolism disorders (IGT, IFG, and diabetes mellitus), associated with hypertension, have important effects on the atherosclerotic risk factor of hypertensive patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: To evaluate whether glucose metabolism disorder affects the cardiovascular risk factors of hypertensive patients.Patients and Methods: Retrospective, cross sectional study includes 242/patients with hypertension (17Ş f / 64 m).
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Key Findings & Data:Participants were classified according to OGTT.
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Conclusion & Impact:Conclusion: Glucose metabolism disorders (IGT, IFG, and diabetes mellitus), associated with hypertension, have important effects on the atherosclerotic risk factor of hypertensive patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: To evaluate whether glucose metabolism disorder affects the cardiovascular risk factors of hypertensive patients.Patients and Methods: Retrospective, cross sectional study includes 242/patients with hypertension (17Ş f / 64 m). Participants were classified according to OGTT. Group I has IGT and diabetes, group II has normal glucose metabolism. Their atherosclerotic risk factors were compared Results: Group I had higher, mean age, systolic and dias-tolic blood pressure, pulse pressure, fasting and second hour glucose of oral glucose tolerance test, and plasma triglyceride level than group II. There was no difference between two groups about body mass index, total choles¬terol, HDL cholesterol fasting insulin and insulin resistan¬ce. There were correlation between pulse pressure and fasting and second hour glucose of OGTT, and body mass index and triglyceride, insulin and insulin resistance. Conclusion: Glucose metabolism disorders (IGT, IFG, and diabetes mellitus), associated with hypertension, have important effects on the atherosclerotic risk factor of hypertensive patients.

Özet

Amaç: Hipertansiyon ve glikoz metabolizma kusuru birbirinden bağımsız, fakat sıklıkla birlikte bulunabilen kardiyovasküler risk faktörleridir. Bu çalışmanın amacı bu iki risk faktörünün bir arada bulunmasının diğer kardiyovasküler risk faktörlerini nasıl etkilediğini incelemektir. Çalışma Planı: Hipertansiyon nedeni ile başvuran ve 75 gr glikoz ile oral glikoz tolerans testi yapılan 178 kadın, 64 erkek olmak üzere 242 hastanın kayıtları irdelendi. OGTT sonuçlarına göre glikoz intoleransı ve diyabetikler bir gruba (Grup I), normal glikoz metabolizmasına sahip olan hastalar diğer bir gruba (Grup II) ayrıldı. Hastaların Hipertansiyon ve vücut kitle indeksleri, total kolesterol, trigliserid, HDL kolesterol, LDL kolesterol, aterojenik indeks, insülin direnci (HOMA), açlık kan şekeri, sistolik ve diyastolik kan basınçları, nabız basınçları karşılaştırıldı. Aterosklerotik hastalık hikayeleri belirlendi ve bu hastalıkların sıklığında farklılıklar araştırıldı. Bulgular: Glikoz metabolizması bozuk olan hipertansif hastaların yaş (< 0.01), sistolik (< 0.05) ve diyastolik (< 0.05) kan basınçları, nabız basınçları (< 0.05), açlık (< 0.0001) ve tokluk glikozları (< 0.01) ve trigliserid seviyeleri (< 0.05) diğer gruba göre anlamlı bir şekilde yüksek bulundu. Açlık (r: 0,135) ve 2. saat plazma glikoz seviyesi (r: 0.131) ile nabız basıncı ve açlık plazma insülin seviyesi ile plazma trigliserid seviyesi arasında pozitif korelasyon saptandı (r: 0,366). Sonuç: Hipertansif hastaların yaşları ilerledikçe, glikoz metabolizmasının bozulabilme riski artmaktadır. Bozuk glikoz metabolizması ile hipertansiyon bir arada bulunur ise ateroskleroz riskleri kötü yönde etkilenmektedir.

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Cite This Article

ARIKAN, E., TUĞRUL, A., KARA, M., GÜLDİKEN, S., ALTUN, B. U. (2022). The effects of glucose metabolism disorder on the cardiovascular risk factor in the patients with hypertension. Endokrinolojide Yönelişler, Cilt: 13 - Sayı: 4, 115–119. https://ajindex.com/articles/500844

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