AI Summary & Key Takeaways
AI InsightIn the light of data of this study, we think that measurement of the lipid parameters may be useful in the management and follow up the patients with clinical and subclinical hypothyroidism.
📌 3 Key Takeaways
Abstract
Cardiovascular system and lipid parameters are affected by overt thyroid disease. Varying results have been obtained from various studies considering these effect in subclinical thyroid diseases. In this study, we compared lipid parameters of the patients with clinical thyroid diseases, and those of the patients diagnosed as subclinical thyroid disease with healthy control subjects. We reevaluated all these parameters statistically after the patients became euthyroid. Lipid parameters of the patients with subclinical hypothyroidism were hot different from those of the control group. Levels of total cholesterol, LDL-cholesterol and apoprotein A were found significantly higher in the group of hypothyroidism compared to those in the control group. There was no significant difference between both groups considering serum levels of HDL - cholesterol, triglyceride,. Lp(a), and apo B. After the patients became euthyroid, it was observed that HDL-cholesterol level increased in subclinical hypothyroidism, LDL-cholesterol level decreased in overt hypothyroidism. In the light of data of this study, we think that measurement of the lipid parameters may be useful in the management and follow up the patients with clinical and subclinical hypothyroidism.
Özet
Aşikar tiroid hastalıklarında kardiyovaskuler sistem ve lipid parametrelerinin etkilendiği bilinmektedir. Subklinik tiroid hastaliklarında ise değişik çalışmalarda farklı sonuçlar elde edilmiştir. Çalışmamizda, klinik ve subklinik hipotiroidi saptanan hastalarda tedavi öncesi ve sonrasi lipid düzeyleri incelenerek sonuçlar sağlıklı kontrol grubu değerleri ile karşılaştırıldı. Subklinik hipotiroidide serum lipid değerleri kontrol grubundan farkli bulunmadi. Aşikar hipotiroidide ise total kolesterol, LDL - kolesterol ve apoprotein A değerleri kontrol grubuna gore anlamlı olarak yüksek bulundu. Hipotiroidi ve kontrol grubunda HDL- kolesterol, trigliserid, Lp(a) ve apo B değerleri arasinda farklılık gözlenmedi. Hastalar otiroid hale geldikten sonra subklinik hipotiroidide HDL - kolesterol duzeylerinde artış, hipotiroidide ise LDL - kolesterol düzeyleri azalmiş olarak bulundu. Bu bulguların ışığında klinik ve subklinik hipotiroidi durumlarında hasta takip ve tedavisinde lipid duzeylerinin ölçümü de önemlidir.