Journals / Endokrinolojide Yönelişler / 2004 / Cilt: 13 - Sayı: 1

The effects of the Chlorella vulgaris on average lipid peroxidation and protein oxidation in the liver tissue of rats treated with sodium nitrit (NaNO2)

Sodyum nitrit (NaNO2) uygulanan sıçanlarda Chlorella vulgaris'in karaciğer dokusunda ortalama lipid peroksidasyonu ve protein oksidasyonu üzerine etkileri

Pages
2–5
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

When lipid peroxidation values were compared between male experiment groups and Control 1, significant differences at p

📌 3 Key Takeaways

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Objective & Hypothesis:t's known that sodium nitrit (NaN02), which is being used as a protector in nutriment materials that has a long shelf life, could be changed to cancerogen N nitroso compounds in vivo.
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Key Findings & Data:This study was planned of 6 experiment and 2 control groups (n = 10).
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Conclusion & Impact:When lipid peroxidation values were compared between male experiment groups and Control 1, significant differences at p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

t's known that sodium nitrit (NaN02), which is being used as a protector in nutriment materials that has a long shelf life, could be changed to cancerogen N nitroso compounds in vivo. Some substances which show antioxidant characteristics might prevent the formation of N nitroso compounds. Chlorella vulgaris which is rich in mineral, vitamin and fenolic groups and has antioxidant characteristic is a fresh water alga that has a special place in Far East diet. This study was planned of 6 experiment and 2 control groups (n = 10). Group 1: NaN02 30 mg/kg (subcutaneous) + Chlorella vulgaris 200 mg/kg (orally) were treated to male rats in every other day. Group 2: NaN02 30 mg/kg (subcutaneous) was treated to the male rats in every other day. Group 3: Chlorella vulgaris 200 mg/kg (orally) was treated to the male rats in every other day. Control 1: Serum physiological that has the same volume with NaN02and Chlorella vulgaris was treated to the male rats in every other day. Group 4, Group 5, Group 6 and control 2 which were made up of female rats were treated with the same procedure as the male groups. At the end of the 2 months of experimental period, lipid peroxidation and protein oxidation levels were determined in liver tissue samples which were taken by sacrification under ether anesthesia. When lipid peroxidation values were compared between male experiment groups and Control 1, significant differences at p

Özet

Uzun raf ömürlü gıda maddelerinde koruyucu katkı maddesi olarak kullanılan sodyum nitrit (NaN02)'in in vivo da kanserojen N nitroso bileşiklerine dönüşebileceği bilinmektedir. Antioksidan özellik gösteren bazı maddeler ise N nitroso bileşiklerinin oluşumunu engellemektedir. Mineral, vitamin ve fenolik gruplar açısından zengin olan ve antioksidan özellik gösteren Chlorella vulgaris bir tatlı su yosunu olup Uzakdoğu diyetinde önemli yer işgal etmektedir. Bu çalışma 6 deney ve 2 kontrol grubu olarak planlandı (n = 10). Grup 1, erkek sıçanlara gün aşırı NaN02 30 mg/kg (deri altı) + Chlorella vulgaris 200 mg/kg (ağızdan) uygulandı. Grup 2, erkek sıçanlara gün aşırı NaN02 30 mg/kg (deri altı) uygulandı. Grup 3, erkek sıçanlara gün aşırı Chlorella vulgaris 200 mg/kg (ağızdan) uygulandı. Kontrol 1, erkek sıçanlara gün aşırı NaN02 ve Chlorella vulgaris hacminde serum fizyolojik uygulandı.Dişi sıçanlardan oluşan Grup 4, Grup 5, Grup 6 ve Kontrol 2 gruplarına erkek deney gruplarına uygulanan işlemlerin aynısı uygulandı. 2 aylık deney süresi sonunda eter anestezisi altında sakrifikasyon ile alınan karaciğer doku örneklerinde lipid peroksidasyon ve protein oksidasyon düzeyleri tespit edildi. Lipid peroksidasyon değerleri erkek deney grupları ile Kontrol 1 arasında karşılaştırıldığında sadece Chlorella vulgaris uygulanan Grup 3 (1.9449 ± 0.13) ile Kontrol 1 (3.8857 ± 0.5665) p

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Cite This Article

TAŞKIN, E., BAYRAKTAR, L., CANER, M., DOĞRUMAN, H. (2022). The effects of the Chlorella vulgaris on average lipid peroxidation and protein oxidation in the liver tissue of rats treated with sodium nitrit (NaNO2). Endokrinolojide Yönelişler, Cilt: 13 - Sayı: 1, 2–5. https://ajindex.com/articles/500833

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