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Journals / Endokrinolojide Diyalog Dergisi / 2009 / Cilt: 6 - Sayı: 4

The role of membrane glycoprotein plasma cell antigen 1 (PC-1) in insulin resistance

İnsülin resistansında membran glikoprotein plazma cell antijen 1′in (PC-1) rolü

Sinan TANYOLAÇ
Pages
226–229
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this article, it was reviewed the role of PC-1 in insulin resistance.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The prevalance of type 2 diabetes mellitus (T2DM) is rapidly increasing in all over the world.
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Key Findings & Data:Insulin resistance plays a major role in the pathogenesis of T2DM and the majority of patients with T2DM have insulin resistance.
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Conclusion & Impact:In this article, it was reviewed the role of PC-1 in insulin resistance.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The prevalance of type 2 diabetes mellitus (T2DM) is rapidly increasing in all over the world. Insulin resistance plays a major role in the pathogenesis of T2DM and the majority of patients with T2DM have insulin resistance. Several studies have shown that overexpresion of membrane glycoprotein plasma cell antigen 1 (PC-1) [ectonucleotide pyrophosphatase phosphodiesterase 1] in muscle, adipose tissue, fibroblasts, and other tissues associated with insulin resistance, obesity and T2DM. Moreover, either experimants in transgenic mice in vivo or in cultured cells in vitro, PC-1 overexpression impairs insulin stimulation of insulin receptor (IR) activation and downstream signaling. In addition, variants in PC-1 gene are associated with insulin resistance, T2DM, and obesity in various ethnic populations. Therefore, PC1 is a strong candidate protein that may play a role in the pathogenesis of T2DM. In this article, it was reviewed the role of PC-1 in insulin resistance.

Özet

Tip 2 diabetes mellitusun (T2DM) prevalansı tüm dünyada hızlı bir artış göstermektedir. İnsülin direnci T2DM'li hastaların birçoğunda görülmekte ve hastalığın patogenezinde önemli bir rol oynamaktadır. Membran glikoprotein plazma hücre antijen 1'in (PC-1) [ectonucleotide pyrophosphatase phosphodiesterase 1] kaslarda, yağ dokusunda, fibroblast ve diğer dokularda fazla miktarda salgılanmasının insülin direnci, obezite ve T2DM ile birliktelik gösterdiği birçok çalışmada bildirilmiştir. Bununla birlikte, gerek in vivo transgenik farelerde gerekse in vitro hücre kültüründe aşırı düzeyde eksprese edilen PC-1, insülin reseptör aktivitesinde ve sinyal mekanizmasında bozulmaya yol açmaktadır. Buna ilave, PC-1 genindeki varyasyonlar çeşitli toplumlarda insülin direnci, T2DM ve obezite ile birliktelik göstermektedir. Bu nedenle, PC-1, T2DM'nin patogenezinde rol oynayabilecek güçlü bir aday proteindir. Bu makalede insülin direncinde PC-1'in rolü gözden geçirilmiştir.

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Cite This Article

TANYOLAÇ, S. (2022). The role of membrane glycoprotein plasma cell antigen 1 (PC-1) in insulin resistance. Endokrinolojide Diyalog Dergisi, Cilt: 6 - Sayı: 4, 226–229. https://ajindex.com/articles/500807

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