Journals / Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.) / 2006 / Cilt: 17 - Sayı: 2

A histopathologic study of the transverse carpal ligament and flexor tenosynovium in patients with idiopathic carpal tunnel syndrome

İdiyopatik karpal tünel sendromlu hastalarda transvers karpal ligaman ve fleksör tenosinovyum örneklerinde histopatolojik çalışma

Pages
72–78
Publication Date
2022-10-18
DOI
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⚡ TL;DR(Too Long; Didn't Read)

The only significant difference was increased vascularity in the study group (78.1% vs 37.5%; p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: In order to establish the histologic etiology of idiopathic carpal tunnel syndrome (CTS), we investigated histologic changes in the transverse carpal ligament and flexor tenosynovium.
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Key Findings & Data:Patients and methods: Biopsy specimens of the transverse carpal ligament and tenosynovium of the 3rd and 4th flexor digitorum superficialis tendons were taken from 39 consecutive patients (37 women, 2 men; mean age 51 years; range 42 to 63 years) who underwent surgery for idiopathic CTS, and from eight control patients (2 women, 6 men; mean age 47 years; range 39 to 55 years) who did not have any complaints or findings related to CTS and were operated on for distal radial intraarticular fractures.
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Conclusion & Impact:The only significant difference was increased vascularity in the study group (78.1% vs 37.5%; p
🔬Design:Research Article
📍Scope:34 specimens
⚙️Variables:Domain Parameters

Abstract

Objectives: In order to establish the histologic etiology of idiopathic carpal tunnel syndrome (CTS), we investigated histologic changes in the transverse carpal ligament and flexor tenosynovium. Patients and methods: Biopsy specimens of the transverse carpal ligament and tenosynovium of the 3rd and 4th flexor digitorum superficialis tendons were taken from 39 consecutive patients (37 women, 2 men; mean age 51 years; range 42 to 63 years) who underwent surgery for idiopathic CTS, and from eight control patients (2 women, 6 men; mean age 47 years; range 39 to 55 years) who did not have any complaints or findings related to CTS and were operated on for distal radial intraarticular fractures. All the specimens were evaluated blindly by the same pathologist. Results: In the study group, 34 specimens of the transverse carpal ligament and 32 specimens of the flexor tenosynovium, and all specimens of the control group were eligible for pathologic evaluation. No pathologic findings were present in the transverse carpal ligament in seven specimens (20.6%) and three specimens (37.5%) in the study and control groups, respectively. The remaining specimens exhibited myxoid degeneration, inflammation, chondrocytic cells, edema, or lipomatosis. Flexor tenosynovium specimens of both groups exhibited at least two pathologic findings, the most common being reactive perivascular mononuclear inflammation. There were no signs of dense lymphocyte infiltration. The only significant difference was increased vascularity in the study group (78.1% vs 37.5%; p

Özet

Amaç: İdiyopatik karpal tünel sendromunda (KTS), hastalığın histolojik etyolojisini ortaya koymak amacıyla transvers karpal ligaman ve fleksör sinovyumda histolojik değişiklikler araştırıldı. Hastalar ve yöntemler: İdiyopatik KTS tanısıyla ameliyat edilen ardışık 39 hastadan (37 kadın, 2 erkek; ort. yaş 51; dağılım 42-63) ve KTS'ye uyan yakınma ve bulguları olmayan, radius distal uç eklemiçi kırığı nedeniyle akut dönemde ameliyat edilen sekiz hastadan (kontrol grubu, 2 kadın, 6 erkek; ortalama yaş 47; dağılım 39-55) ameliyat sırasında transvers karpal ligaman ile 3-4. fleksör digitorum süperfisyalis tendonlarının sinovyumundan biyopsi örnekleri alındı. Tüm örnekler aynı patolog tarafından kör olarak değerlendirildi. Bulgular: Çalışma grubunda 34 transvers karpal ligaman ve 32 fleksör tenosinovyum örneği, kontrol grubunda tüm örnekler histolojik incelemeye alındı. Çalışma grubunda yedi (%20.6), kontrol grubunda üç (%37.5) transvers karpal ligaman örneğinde patolojik bulgu saptanmadı. Diğer örneklerde miksoid dejenerasyon, enflamasyon, kondrositik hücre, ödem ve lipomatozis görüldü. Fleksör tenosinovyum örneklerinde her iki grupta da en az iki patolojik bulgu saptandı. En yaygın bulgu perivasküler seyrek mononükleer iltihabi yanıt şeklinde enflamasyondu. Yoğun lenfosit infiltrasyonuna rastlanmadı. Çalışma grubu yalnızca vaskülarite artışı açısından anlamlı farklılık gösterdi (%78.1 ve %37.5; p

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Cite This Article

DERVİŞOĞLU, S., ALBAYRAK, M., MUMCUOĞLU, İ. E., BAGATUR, A. E., ZORER, G., DOĞAN, A. (2022). A histopathologic study of the transverse carpal ligament and flexor tenosynovium in patients with idiopathic carpal tunnel syndrome. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.), Cilt: 17 - Sayı: 2, 72–78. https://ajindex.com/articles/498823

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