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Journals / Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.) / 2014 / Cilt: 25 - Sayı: 2

Metotreksat içeren kalsiyum fosfat çimentosu etrafına kollajen membran sarımıyumuşak doku iyileşmesindeki yan etkileri azaltır

Collagen membrane wrapping around methotrexate-containing calcium-phosphate cement reduces the side effects on soft tissue healing

Alp AKMAN
Semih AKKAYA
Gamze DOĞU GÖKÖZ
Anıl S UZUN
A. Fahir DEMİRKAN
Pages
96–101
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Membrane wrapping may allow administration of higher doses of an anti-neoplastic drug which can be more effective

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: This study aims to evaluate whether the collagen membrane (membrane) wrapping around the methotrexate (MTX)-containing calcium-phosphate cement (CPC) reduces the side effects on soft tissue healing.
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Key Findings & Data:Material and methods: In 36 rats, femoral bone defects were created and treated in six groups which were CPC only, CPC and membrane wrapping around, CPC containing 2% MTX, CPC containing 2% MTX and membrane wrapping around, CPC containing 5% MTX, CPC containing 5% MTX and membrane wrapping around.
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Conclusion & Impact:Membrane wrapping may allow administration of higher doses of an anti-neoplastic drug which can be more effective
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: This study aims to evaluate whether the collagen membrane (membrane) wrapping around the methotrexate (MTX)-containing calcium-phosphate cement (CPC) reduces the side effects on soft tissue healing. Material and methods: In 36 rats, femoral bone defects were created and treated in six groups which were CPC only, CPC and membrane wrapping around, CPC containing 2% MTX, CPC containing 2% MTX and membrane wrapping around, CPC containing 5% MTX, CPC containing 5% MTX and membrane wrapping around. Results: Histological examinations revealed a statistically significantly improved healing in the connective tissue samples of the CPC containing 5% MTX group wrapped around by membrane compared to those without membrane (p=0.04). However, this was not seen in other groups. Conclusion: Membrane wrapping around the CPC containing MTX reduces the side effect of MTX on cellular proliferation at its highest concentration, particularly. Membrane wrapping may allow administration of higher doses of an anti-neoplastic drug which can be more effective

Özet

Amaç: Bu çalışmada metotreksat (MTX) içeren kalsiyumfosfat çimentosu (KFÇ) etrafına kollajen membran (membran) sarımının yumuşak doku iyileşmesindeki yan etkileri azaltıp azaltmadığı değerlendirildi.Gereç ve yöntemler: Otuz altı sıçan femurunda kemik defekti oluşturuldu ve sadece KFÇ, etrafı membranla sarılmış KFÇ, %2 MTX içeren KFÇ, etrafı membranla sarılmış ve %2 MTX içeren KFÇ, %5 MTX içeren KFÇ, etrafı membranla sarılmış ve %5 MTX içeren KFÇ şeklinde altı grupta tedavi uygulandı.Bulgular: Histolojik incelemelerde bağ dokusunda etrafı membranla sarılmış %5 MTX içeren grupta, membran içermeyen %5 MTX'li gruba göre istatistiksel anlamlı şekilde daha iyi bağ doku iyileşmesi görüldü (p=0.04). Diğer gruplarda buna rastlanmadı.Sonuç: Metotreksat içeren KFÇ'nin etrafının membran ile sarılmasının, MTX'in hücresel çoğalma üzerinde, özellikle yüksek konsantrasyonlardaki yan etkilerini azaltır. Membran sarımı, antineoplastik ajanların daha yüksek konsantrasyonlarda verilmesini sağlayarak, daha etkili tedavi verilmesini sağlayabilecektir

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Cite This Article

AKMAN, A., AKKAYA, S., GÖKÖZ, G. D., UZUN, A. S., DEMİRKAN, A. F. (2022). Metotreksat içeren kalsiyum fosfat çimentosu etrafına kollajen membran sarımıyumuşak doku iyileşmesindeki yan etkileri azaltır. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.), Cilt: 25 - Sayı: 2, 96–101. https://ajindex.com/articles/498594

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