Journals / Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.) / 2016 / Cilt: 27 - Sayı: 1

Zoledronik asit tedavisi sonrası atipik femoral kırık

Atypical femoral fracture following zoledronic acid treatment

Pages
54–57
Publication Date
2022-10-18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Prophylactic surgical fixation was performed with titanium elastic nails.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:A 68-year-old female patient admitted to our clinic with right anterior thigh pain ongoing for six months and which increased in last two months.
📊
Key Findings & Data:The patient had been followed-up for 15 years because of osteoporosis and administrated alendronate and ibandronate treatment for 10 years.
💡
Conclusion & Impact:Prophylactic surgical fixation was performed with titanium elastic nails.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

A 68-year-old female patient admitted to our clinic with right anterior thigh pain ongoing for six months and which increased in last two months. The patient had no trauma history. The patient had been followed-up for 15 years because of osteoporosis and administrated alendronate and ibandronate treatment for 10 years. Patient had three shots of zoledronate once a year during the last three years. Her pain was increasing when she was walking. Physical examination revealed pain in her right thigh. Radiogram showed thickened lateral cortex of the subtrochanteric area. Magnetic resonance imaging also showed thickening and edema of the same area. These images were correlated with atypical fracture in right femoral subthrochanteric zone. Dual energy X-ray absorptiometry revealed that T score was -3.3 in lumbar region and -2.5 in femoral neck. Zoledronate treatment was ended. Prophylactic surgical fixation was performed with titanium elastic nails.

Özet

Altmış sekiz yaşında bir kadın hasta altı aydır devam eden ve son iki aydır artan sağ ön uyluk ağrısı ile kliniğimize başvurdu. Hastanın travma öyküsü yoktu. Hasta 15 yıldır osteoporoz nedeniyle takip ediliyor, kendisine 10 yıldır alendronat ve ibandronat tedavisi uygulanıyordu. Hastaya son üç yılda, yılda bir kez zolendronat enjeksiyonu yapılmıştı. Ağrısı yürürken artmaktaydı. Fiziksel muayenede sağ uyluğunda ağrı olduğu tespit edildi. Radyogramda subtrokanterik bölgede lateral kortekste kalınlaşma olduğu görüldü. Manyetik rezonans görüntülemede de aynı bölgede kalınlaşma ve ödem olduğu görüldü. Bu görüntüler sağ femoral subtrokanterik bölgede atipik kırık ile ilişkiliydi. Çift enerjili X-ışın absorbsiyometri T skorunun lumbar bölgede -3.3, femur boynunda -2.5 olduğunu ortaya koydu. Zolendronat tedavisine son verildi. Titanyum elastik çiviler ile profilaktik cerrahi tespit uygulandı.

🔖

Cite This Article

ATAOĞLU, B., KAPTAN, A. Y., EREN, T. K., YAPAR, A. E., BERKAY, A. F. (2022). Zoledronik asit tedavisi sonrası atipik femoral kırık. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.), Cilt: 27 - Sayı: 1, 54–57. https://ajindex.com/articles/498503

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Atik OS, Uslu MM, Eksioglu F, Satana T. Etiology of senile osteoporosis: a hypothesis. Clin Orthop Relat Res 2006;443:25-7
  2. Atik OS, Gunal I, Korkusuz F. Burden of osteoporosis. Clin Orthop Relat Res 2006;443:19-24
  3. Nieves JW, Cosman F. Atypical subtrochanteric and femoral shaft fractures and possible association with bisphosphonates. Curr Osteoporos Rep 2010;8:34-9
  4. Ataoğlu MB, Atik OŞ, Gül O, Sarıkaya B, Görmeli G, Öztürk BY, et al. A comparison of the measurements with biochemical markers of bone turnover and bone mineral density in the assessment of the efficiency of osteoporosis treatment. [Article in Turkish] Eklem Hastalik Cerrahisi 2013;24:82-6
  5. Somford MP, Draijer FW, Thomassen BJ, Chavassieux PM, Boivin G, Papapoulos SE. Bilateral fractures of the femur diaphysis in a patient with rheumatoid arthritis on longterm treatment with alendronate: clues to the mechanism of increased bone fragility. J Bone Miner Res 2009;24:1736-40
  6. Ayanaoğlu T, Atik OŞ, Tokgöz N, Uçar M. Sacral and pubic insufficiency fractures due to bisphosphonate treatment. Eklem Hastalik Cerrahisi 2015;26:120-4
  7. Odvina CV, Zerwekh JE, Rao DS, Maalouf N, Gottschalk FA, Pak CY. Severely suppressed bone turnover: a potential complication of alendronate therapy. J Clin Endocrinol Metab 2005;90:1294-301
  8. Atik OS, Suluova F, Görmeli G, Yildirim A, Ali AKh. Insufficiency femoral fractures in patients undergoing prolonged alendronate therapy. Eklem Hastalik Cerrahisi 2010;21:56-9
  9. Kwek EB, Goh SK, Koh JS, Png MA, Howe TS. An emerging pattern of subtrochanteric stress fractures: a long-term complication of alendronate therapy? Injury 2008;39:224-31
  10. Hillner BE, Ingle JN, Chlebowski RT, Gralow J, Yee GC, Janjan NA, et al. American Society of Clinical Oncology 2003 update on the role of bisphosphonates and bone health issues in women with breast cancer. J Clin Oncol 2003;21:4042-57
  11. Kanis JA, Burlet N, Cooper C, Delmas PD, Reginster JY, Borgstrom F, et al. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 2008;19:399-428
  12. Reddy SV, Gupta SK. Atypical femoral shaft fracture in a patient with non-metastatic prostate cancer on zoledronic acid therapy: effect of therapy or coincidence? Singapore Med J 2012;53:52-4
  13. Kim YS, Park WC. Atypical subtrochanteric femur fracture in patient with metastatic breast cancer treated with zoledronic Acid. J Breast Cancer 2012;15:261-4
  14. McClung M, Harris ST, Mi