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Journals / Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.) / 2019 / Cilt: 30 - Sayı: 3

Is there an association of hematopoietic stem cell and endothelial progenitor cell markers with maturation in forearm arterial repair?

Hematopoetik kök hücre ve endotelyal progenitör hücre belirteçleri ile önkolun arteriyel onarımındaki olgunlaşma arasında ilişki var mıdır?

İbrahim Halil KAFADAR
Serap DOĞAN
İbrahim KARAMAN
Ali Eray GÜNAY
Zehra Filiz KARAMAN
Pages
289–295
Publication Date
2022-10-18
DOI
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⚡ TL;DR(Too Long; Didn't Read)

The mean CD34expression level was 72.09±3.00 in the group with maturationwhereas it was 54.64±7.34 in the group without maturation,indicating a statistically significant difference (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: This study aims to assess the effects of thehematopoietic stem cells and endothelial progenitor cells inperipheral blood and monocyte cluster of differentiation (CD) 34,CD133 and CD309 expression levels on maturation at the repairsite in patients who underwent forearm arterial repair.Patients and methods: This prospective study included30 patients (23 males, 7 females; mean age 28.9±1.8 years; range,18 to 49 years) with a well-defined cut at the wrist due to a stabbinginjury but no comorbid condition who presented to the emergencydepartment of our hospital between November 2014 and November2017.
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Key Findings & Data:The relationships between patency and hematopoieticstem and endothelial progenitor cell markers such as CD34, CD133and CD309 were assessed by flow cytometry.Results: The patients were divided into two groups according topresence of sufficient flow in the arteries repaired.
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Conclusion & Impact:The mean CD34expression level was 72.09±3.00 in the group with maturationwhereas it was 54.64±7.34 in the group without maturation,indicating a statistically significant difference (p
🔬Design:Research Article
📍Scope:2014 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: This study aims to assess the effects of thehematopoietic stem cells and endothelial progenitor cells inperipheral blood and monocyte cluster of differentiation (CD) 34,CD133 and CD309 expression levels on maturation at the repairsite in patients who underwent forearm arterial repair.Patients and methods: This prospective study included30 patients (23 males, 7 females; mean age 28.9±1.8 years; range,18 to 49 years) with a well-defined cut at the wrist due to a stabbinginjury but no comorbid condition who presented to the emergencydepartment of our hospital between November 2014 and November2017. Vascular patency was assessed by Doppler sonography inpatients who underwent forearm arterial repair via micro-vasculartechniques. The relationships between patency and hematopoieticstem and endothelial progenitor cell markers such as CD34, CD133and CD309 were assessed by flow cytometry.Results: The patients were divided into two groups according topresence of sufficient flow in the arteries repaired. The mean CD34expression level was 72.09±3.00 in the group with maturationwhereas it was 54.64±7.34 in the group without maturation,indicating a statistically significant difference (p

Özet

Amaç: Bu çalışmada, periferik kan ve monositlerdeki hematopoetik kök hücre ve endotelyal progenitör hücre farklılaşma yığılım molekülleri (CD) 34, CD133 ve CD309 ekspresyon düzeylerinin önkolun arteriyel onarımı yapılan hastalarda onarım sahasındaki olgunlaşma üzerindeki etkileri değerlendirildi. Hastalar ve yöntemler: Bu prospektif çalışmaya elbileğinde saplanıcı bir yaralanmaya bağlı iyi tanımlanmış kesiği olup eşlik eden durumu olmayan, Kasım 2014 ve Kasım 2017 tarihleri arasında hastanemizin acil servisine başvuran 30 hasta (23 erkek, 7 kadın; ort. yaş 28.9±1.8 yıl; dağılım, 18-49 yıl) dahil edildi. Önkolda mikrovasküler tekniklerle arteriyel onarım yapılan hastaların vasküler açıklığı Doppler sonografi ile değerlendirildi. Açıklık ve CD34, CD133 ve CD309 gibi hematopoetik kök ve endotelyal progenitör hücre belirteçleri arasındaki ilişkiler akış sitometrisi ile değerlendirildi. Bulgular: Hastalar tamir edilen arterlerde yeterli akım olup olmamasına göre iki gruba ayrıldı. Ortalama CD34 ekspresyon düzeyi olgunlaşma olan grupta 72.09±3.00 iken olgunlaşma olmayan grupta 54.64±7.34 idi ve bu, istatistiksel olarak anlamlı farklılığa işaret etti (p

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Cite This Article

KAFADAR, İ. H., DOĞAN, S., KARAMAN, İ., GÜNAY, A. E., KARAMAN, Z. F. (2022). Is there an association of hematopoietic stem cell and endothelial progenitor cell markers with maturation in forearm arterial repair?. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.), Cilt: 30 - Sayı: 3, 289–295. https://ajindex.com/articles/498373

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