Journals / Ege Tıp Dergisi / 2018 / Cilt: 57 - Sayı: 4

Assestment of subclinical atherosclerosis in glucose metabolism disorders

Glukoz metabolizma bozukluklarında subklinik aterosklerozun değerlendirilmesi

Pages
185–190
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Non invasive measurement of CIMT, EFT and retinal vascular changes detected by OCTA are useful and feasible tools for the assessment of subclinical atheroscleoris in patients with glucose metabolism disorders.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: It is a well-known complication that diabetes (DM) and prediabetes (PD) affectsvascular structures and eye.
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Key Findings & Data:Materials and Methods: Between May 2017- June 2017 consecutive 19 patients with PD and 12 patients with D were enrolled into the study.
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Conclusion & Impact:Conclusion: Non invasive measurement of CIMT, EFT and retinal vascular changes detected by OCTA are useful and feasible tools for the assessment of subclinical atheroscleoris in patients with glucose metabolism disorders.
🔬Design:Lab & Field Experiment
📍Scope:2017 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: It is a well-known complication that diabetes (DM) and prediabetes (PD) affectsvascular structures and eye. In our study we aim to find out the atherosclerotic changes in patients with PD and DM by using carotis intima-media thickness (CIMT), epicardial fat thickness (EFT) and rusing optical coherence tomography angiography (OCTA). Materials and Methods: Between May 2017- June 2017 consecutive 19 patients with PD and 12 patients with D were enrolled into the study. They compared with age sex matched control (C) group consisted of 31 individuals who have normal blood glucose levels. Patients with coronary artery disease was excluded. Measurements of CIMT, EFT and retinal and choroidal vascular changes by using OCTA technique obtained from our study group were recorded and compared with each other. Results: Twelve patients with D (5 male,7 female, mean age 54.2±6.2), 19 patients with PD (8 male, 11 female, mean age 51±8.6) and 31 C group (13 male, 18 female, mean age 50.9±11.2) were included in the study. The highest value of CIMT was found in patients wih D following by patients with PD and control group had the lowest values. There was no difference between groups in EFT. The most common findings in OCTA were non-perfussion, FAZ (foveal avascular zone) erosion and venous pooling. Similarly these findings were more frequent in patient DM following by patients with PD. Conclusion: Non invasive measurement of CIMT, EFT and retinal vascular changes detected by OCTA are useful and feasible tools for the assessment of subclinical atheroscleoris in patients with glucose metabolism disorders.

Özet

Amaç: Diyabet (D) ve prediyabette (PD) vasküler yapıların ve gözün etkilenmesi bilinen bir komplikasyondur. Çalışmamızda PD ve D hastalarında damarsal yapılardaki değişiklikleri karotis intima-media kalınlığı (KIMK) ve epikardiyal yağ kalınlığı (EYK) ölçerek ateroskleroz gelişim riski açısından, gözde ise optik koherens tomografi anjiografi (OKTA) kullanarak retinal ve koroidal vasküler değişiklikler açısından sunmayı amaçladık. Gereç ve Yöntem: Çalışmamızda Mayıs 2017- Haziran 2017 tarih aralığındaki laboratuar verilerine göre prediyabet ve diyabet tanısı alan hastalarda KIMK, EYK ölçümü ile ateroskleroz riski ve OKTA tekniği ile retinal ve koroidal vasküler değişiklikler; 19 prediyabetik, 12 diyabetik olguda, hastaların yaşı ve cinsiyeti benzer olan 31 normal kan şekeri seviyesine sahip bilinen koroner arter hastalığı olmayan kontrol (K) grubu ile karşılaştırılarak kaydedildi. Bulgular: Diyabetik 12 hasta (7 kadın, 5 erkek, ortalama yaş 54.2±6.2), PD 19 hasta (ortalama yaş 51±8.6, 11 kadın, 8 erkek) ve 31 K grubu (ortalama yaş 50,9±11.2, 18 kadın, 13 erkek) çalışmaya dahil edilmiştir. KIMK en yüksek diyabetli hastalarda, daha sonra PD ve en az miktarda kontrol hastalarında bulunmuştur. EYK'de gruplar arası farklılık ayırtedilmedi. OKTA verilerine göre en sık bulgu non-perfüzyon, FAZ (foveal avaskuler zon) erozyonu ve venöz göllenme olup en fazla diyabetli hastalarda, sonra PD ve en az K grubunda izlenmiştir. Sonuç: Subklinik aterosklerozun belirteçleri olan KIMK ve EFT’ye ek olarak retinal vasküler hastalıkların OKTA ile girişimsel olmayan yöntemlerle değerlendirmesinde glukoz metabolizması bozukluğu olan hastaların risk değerlendirilmesinde katkı sağlayacaktır.

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Cite This Article

AYDIN, E., ALTIN, C., EMRE, S., AĞILDERE, M., TEKİNDAL, M. A. (2022). Assestment of subclinical atherosclerosis in glucose metabolism disorders. Ege Tıp Dergisi, Cilt: 57 - Sayı: 4, 185–190. https://ajindex.com/articles/496167

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