Journals / Ege Pediatri Bülteni / 2003 / Cilt: 10 - Sayı: 2

The importance of iron therapy in children with breath holding spells

Katılma nöbetli çocuklarda demir tedavisinin önemi

Pages
61–65
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In recent studies, it is concluded that in some patients iron-deficiency anemia may be a factor contributing both to psychomotor development and breath-holding spells.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Breath-holding spells are a common problem in early childhood.
📊
Key Findings & Data:We evaluated 50 children who had breath-holding spells hematologicially age of patients was between 6 months and 4 years.
💡
Conclusion & Impact:In recent studies, it is concluded that in some patients iron-deficiency anemia may be a factor contributing both to psychomotor development and breath-holding spells.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Breath-holding spells are a common problem in early childhood. In recent studies, it is concluded that in some patients iron-deficiency anemia may be a factor contributing both to psychomotor development and breath-holding spells. We evaluated 50 children who had breath-holding spells hematologicially age of patients was between 6 months and 4 years. Patients who were diagnosed to have iron-deficiency anemia were given iron treatment for 3 months at a dose of 6 mg/kg/24h orally. Every month the decrease in the frequency of spells were noted and after 3 months we reevaluated the patients for remission after three months, children treated with iron, showed significant reduction in the frequency of spells. In the anemic group, complete and partial response to iron therapy was 85.3% and in the non-anemic group it was. 37.5%. The treated group showed a positive correlation between low hemoglobin levels and clinical response. For obstructive pathologies, otorhinolaryngology consultation was performed. 7 patients had adenoid hypertrophy, one patient had a thyroglassal duct cyst. Children with breath-holding spells have an underlying autonomic nervous system dysregulation. This dysregulation acts together with emotional factors and iron-deficiency anemia increases tendency toward breath-holding spells. We conclude that in the patients with anemia, iron treatment may reduce the frequency and severity of breath-holding spells.

Özet

Katılma nöbetleri, erken çocukluk çağında sık rastlanan bir problemdir. Son zamanlarda demir eksikliği anemisinin psikomotor gelişime etkisi ve katılma nöbetlerine eğilimi arttırması ile ilgili çalışmalar önem kazanmıştır. 50 katılma nöbetli çocuğun hematolojik değerlendirmesi yapıldı. Yaşları 6 ay-4 yaş arasında değişmekteydi. Demir eksikliği anemisi saptanan olguya, 3 ay süre ile 6 mg/kg/gün oral demir tedavisi verildi. Her ay nöbet sıklığındaki azalma tespit edilerek 3. ay sonrasında remisyon değerlendirildi. Üç aylık demir tedavisi sonrasında, anemili olguların aylık nöbet atağında azalma belirgin olarak bulundu. Tam ve kısmi yanıt anemili grupta %85.3, anemisi olmayan grupta ise %37.5 saptandı. Anemi grubunun, demir tedavisine yanıtında, hemoglobin düzeylerindeki düşüklük ile klinik yanıt arasında pozitif korelasyon bulundu. Obstrüktif patolojiler açısından KBB konsültasyonu yapıldı. 7 vakada adenoid hipertrofisi, 1 vakada tiroglossal duktus kisti saptandı. Katılma nöbetlerinde otonom disregülasyonla emosyonel faktörler etkileşmekte olup demir eksikliği bu yönelimi arttırmaktadır. Bu çalışma sonunda, katılma nöbetlerinin şiddeti ve sıklığının azaltılmasında anemili olgularda demir tedavisinin çok önemli olduğu ortaya konmuştur.

🔖

Cite This Article

KAZANCI, E., AYDOĞAN, A., ALTINÖZ, S., KAVAKLI, T. (2022). The importance of iron therapy in children with breath holding spells. Ege Pediatri Bülteni, Cilt: 10 - Sayı: 2, 61–65. https://ajindex.com/articles/495837

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (1)

  1. Dirik E. Katılma nöbeti. Özgün T. Nonepileptik paroksismal fenomenler. Ayın Kitabı 77. İzmir, 1995:24-36. 2.Evans OB. Breath holding spells. Pediatr Ann 1997; 26:410-414. 3.Dimario FJ Jr, Chee CM, Berman PH. The evaluation of the autonomic nervous system in children with pallid breath-holding spells. Clin Pediatr. 1990; 29:17-24. 4. Oski FA, Honig AS. The effects on the developmental scores of iron-deficient infants. J Pediatr 1978; 92:21-25. 5. Holowach J, Thurston DL. Breath-holding spells and anemia. N Engl J Med 1963; 268:21-23. 6. Daoud AS, batieha A, Al-Sheyyab M, Abuek Teish F, Hijazi S. Effectiveness of iron therapy on breathholding spells. J Pediatr 1997;130:547-550. 7. Dimario FJ Jr. Breath-Holding spells in Childhood. AJDC 1992; 146:125-131. 8. Lobroso CT, Lerman P. Breath-holding spells (cyanotic and pallid infantile syncope). Pediatrics 1967; 39:563-581. 9. Mark S, Vigevans F. Systemic Nonegileptic Paroxysmal Disorders of Neonates and infants, eds, Engel J Jr, Pedley TA. Epilepsy: a Comprehensive Textbook. 1997:2671 -2680. 10. Connor JR. Iron acquisition and expression of iron regulatory proteins in the develoging brain: manipulation by ethanol exposure, iron deprivation and cellular dysfunction. Dev Neurosci 1994; 16:233-247. 11. PolittE, Leibel RL. Iron deficiency and behavior. J Pediatr 1976;88:372-381. 12. Corner JR, Menzies SL. Altered cellular distribution of iron in the central nervous system of miyelin deficient rats. Neuroscienc 1990; 34:265-271. 13. Connor JR, Menzies SL. Relationship of iron to oligo dendrocytes and miyelination. Glia 1996; 17:83-93. 14. Youdim MB, Yehuda S. The neurochemical basis of cognitive deficits in duced by brain iron deficiency: involvement of dopamine-opiate system. Cell Mol Bid 2000; 46 (3): 491-500. 15. Conor JR, Benkovic SA. Iron regulation in the brain: Histochemicd, biochemical and molerular considerations. Ann Neurol 1992; 32:51-61. 16. Mocan MC, Mocan H, Aslan Y, Erduran E. Iron therapy in breath-holding spells and cerebral erythropoetin. Pediatrics 1998; 133: 583-584. 17. Masuda S, Okano M, Yamagishi. K, Nagao M, Ueda M, Sasaki R. A novel site of erythropoetin production: oxygen-dependent production in cultured rat astrocytes. J Biol Chem 1994; 269:194 88-93. 18. Craig B, James M, Krafçik J. Pediatr Surg 2000; 35:1381 -1384. 19. Dimario FJ, Sarfarazi M. Family pedigree analysis of children with severe breath-holding spells. J Pediatr 1997; 130:647-651.