Journals / Ege Pediatri Bülteni / 2003 / Cilt: 10 - Sayı: 1

Necrotizing enterocolitis: Incidence, diagnostic criteria, risk factors, treatment and mortality values in 35 cases

Nekrotizan enterokolit: 35 olguda insidans, tanı kriterleri, risk faktörleri, tedavi ve mortalite değerleri

Pages
1–6
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The overall mortality was found as 48.57% and necrotizing enterocolitis was responsible from 7.07% of mortality between premature patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:With advances in Neonatology and neonatal intensive care medicine the rate of premature survival has improved and for that reason incidence of patients with necrotizing enterocolitis has increased in the last 30 years and it has been an important cause of morbidity and mortality particularly in premature newborns.
📊
Key Findings & Data:Thirty premature patients out of 414 were diagnosed as necrotizing enterocolitis in the years between June 1995 - July 1996.
💡
Conclusion & Impact:The overall mortality was found as 48.57% and necrotizing enterocolitis was responsible from 7.07% of mortality between premature patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

With advances in Neonatology and neonatal intensive care medicine the rate of premature survival has improved and for that reason incidence of patients with necrotizing enterocolitis has increased in the last 30 years and it has been an important cause of morbidity and mortality particularly in premature newborns. In this study, we evaluated the demographical data, incidence, clinical presentation, radiological findings and treatment characteristics of our patients with necrotizing enterocolitis in our hospital in one year period. Thirty premature patients out of 414 were diagnosed as necrotizing enterocolitis in the years between June 1995 - July 1996. Therefore incidence for prematurity was calculated as 7.4%. On the other hand, 5 patients out of 2523 (incidence 0.19%) term newborn baby was diagnosed as having the same disease in this time period. The majority of the patients were males (57.14%) and most of them had gestational age of $leq$32 weeks (42.85%). Average birth weight was 1778 (± 626) grams. The average beginning day of the symptoms was 10.4 (±9.8) days. The symptoms appeared latest, with an average of 13,4 days, in the patient group with birthweights$leq$1500 grams. The most frequently seen clinical symptoms were gastric residuals, abdominal distention and vomiting. Sepsis was found in 21 patients in association with necrotizing enterocolitis. Trombocytopenia was the most frequent finding (68.57%) among the laboratory tests. Dilated bowel loops and ileus patterns were the most frequent radiological findings. 54.28% of the patients were Grade 1 necrotizing enterocolitis: Prematurity was themost frequently encountered risk factor and surgery was indicated in 5 patients. The overall mortality was found as 48.57% and necrotizing enterocolitis was responsible from 7.07% of mortality between premature patients. In conclusion, NEC is frequently encountered in premature and very low birthweight infants and particularly in formula fed babies.

Özet

Neonatolojideki ve yoğun bakım olanaklarındaki gelişmelere bağlı olarak prematüre yaşam oranları artmış ve son 30 yılda nekrotizan enterokolitli olgu sayısı artarak bu hastalık özellikle prematüriteli olgular için önemli bir morbidite ve mortalite nedeni haline gelmiştir. Çalışmamızda Dr. Behçet Uz Çocuk Hastanesinde 1 yıllık süre içerisinde izlenen yenidoğan ve prematüre nekrotizan enterokolitli olgular incelenerek olguların demografik özellikleri, insidans, klinik ve radyolojik bulguları ve tedavi özellikleri değerlendirilmiştir. Haziran 1995 - Temmuz 1996 tarihleri arasında 414 prematüre bebekden 30'u nekrotizan enterokolit tanısı almıştır (insidans %7.24). Diğer yandan, aynı dönemde izlenen 2523 terminde yenidoğan bebek arasından ise 5 olgu (insidans %0.19) aynı tanıyı almıştır. Olguların çoğunluğunu (%57.14) erkek ve gestasyonel yaşı $leq$32 hafta (%42.85) olan bebekler oluşturmaktaydı. Ortalama doğum ağırlığı 1778 (±626) gramdı. Semptomların başlama günü ortalama 10.4 (±9.8) gündü. 1500 gramın altında doğum ağırlığı olanlarda ise semptomlar 13,4 gün ile en geç olarak görülmüştü. En sık rastlanan semptomlar gastrik rezidü, abdominal distansiyon, ve kusma olarak saptandı. Olguların 21'inde nekrotizan enterokolit sepsis ile birlikte bulunmaktaydı. Laboratuvar değerlerinde trombositopeni en sık rastlanan (%68.57) bulgu idi. En sık saptanan radyolojik bulgular dilate barsak ansları ve ileus bulguları olmuştur. Olguların %54.28'i Evre 1 nekrotizan enterokolit grubunda değerlendirildi. Prematürite en sık rastlanan risk faktörü olurken, 5 olguda cerrahi girişim uygulandı. Genel mortalite %48.57 olarak bulunmuş ve bu çalışma döneminde prematüriteye bağlı ölümlerin %7.07'sinden nekrotizan enterokolit sorumlu tutulmuştur. Sonuç olarak NEK sıklıkla prematürite ve düşük doğum ağırlıklı bebeklerde görülen ve formula ile beslenenlerde daha fazla karşılaştığımız bir hastalıktır.

🔖

Cite This Article

ETENSEL, B., CEYLAN, H., GÜNŞAR, C., ÇÜN, S., MİR, E., ŞENCAN, A. (2022). Necrotizing enterocolitis: Incidence, diagnostic criteria, risk factors, treatment and mortality values in 35 cases. Ege Pediatri Bülteni, Cilt: 10 - Sayı: 1, 1–6. https://ajindex.com/articles/495829

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Cathy MG, Azizkhan RG. Necrotizing enterocolitis, in Pediatric Surgery Ashcraft KW, Murphy JP, Sharp RJ, Sigalet DL, Snyder CL, eds. WB Saunders Company, 3rd ed, Philadelphia, 2000: 443-452
  2. Albanese CT, Rowe MI. Necrotizing enterocolitis in Pediatric Surgery, OÕNeill JA, Rowe MI, Grosfeld JL, Fonkalsrud EW, Coran AG eds., Cilt 2, Beşinci baskı, Mosby-Year Book, St Louis, Missouri, 1998: 1297-1320
  3. Kurscheid T, Holschneider AM. Necrotizing enterocolitis-Mortality and long term results. Eur J Pediatr Surg 1993; 3: 139-143
  4. Beeby PJ, Heather Jeffery. Risk factors for necrotising enterocolitis: the influence of gestational age. Archives of Disease in Childhood 1992; 67: 432-435
  5. Rowe MI, Reblock KK, Kurkchubasche AG, Healey PJ. Necrotizing enterocolitis in the extremely low birth weight infant. J Pediatr Surg 1994; 29: 987-990
  6. Michele J, Walsh MD, Robert M, Kliegman MD. Necrotizing enterocolitis: Treatment based on staging criteria. Pediatr Clin Nort Am 1986; 33: 1
  7. Kosloske AM. Epidemiology of necrotizing enterocolitis. Acta Pediatrica Suppl 1994; 396: 2-7
  8. Wilson R, del Portillo M, Schmidt E, et al. Risk factors for necrotizing enterocolitis in infants weighing more than 2000 grams at birth: A case control study. Pediatrics 1983; 71: 19-22
  9. Aslan Y, Ayvaz A, Yıldıran A, ve ark. Nekrotizan enterokolit: 62 olgunun değerlendirilmesi. Pediatrik Cerrahi Dergisi 2001; 15: 20-27
  10. Narang A, Rao R, Bhakoo ON. Neonatal necrotizing enterocolitis: a clinical study. Indian Pediatr 1993; 30: 1417-1422
  11. MacKendrick W, Caplan M. Necrotizing enterocolitis - New thoughts about pathogenesis and potential treatment. Pediatr Clin Nort Am 1993; 40: 1047-1059
  12. Okur H, Küçükaydın M, Köse K, et al. Hypoxia-induced necrotizing enterocolitis in the immature rat: the role of lipid peroxidation and management by vitamin E. J Pediatr Surg 1995; 30: 1416-1419
  13. Johnson L, Bowen FW Jr, Abbasi S, et al. Relationship of prolonged pharmacologic serum levels of vitamin E to incidence of sepsis and necrotizing enterocolitis in infants with birth weight 1,500 grams or less. Pediatrics 1985; 75: 619-638
  14. O'Neill JA, Stahlman MT, Meng HC. Necrotizing enterocolitis in the newborn: Operative indications. Ann Surg 1975; 182: 274-279
  15. Yu VY, Tudehope DI. Neonatal necrotizing enterocolitis 2. Perinatal risk factors. Med J Austr 1977; 1: 688-693
  16. Bell MJ, Ternberg JL, Feigin RD, et al. Neonatal enterocolitis: Therapeutic decisions based upon clini