Journals / Ege Pediatri Bülteni / 2004 / Cilt: 11 - Sayı: 2

Duodenal pathologies in pediatric patients undergoing upper gastrointestinal endoscopy adolescents

Çocuklarda üst gastrointestinal sistem endoskopilerinde duodenal patolojiler

Pages
107–112
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The negative predictive value of a normal appearing duodenal mucosa was found 90% arid pozitif prediktif value %68.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim of this study, to determine the significance and rate of duodenal pathology during Eosophagogastroduodenoscopy (EGDs) in childhood and relation to pathological diagnosis.
📊
Key Findings & Data:We evaluated 227 diagnostic EGDs with duodenal biopsies performed in consecutive infants (mean age; 6 month to 20 years; average age, 10.6 years) during the 24-month period from August 2000 to August 2002 retrospectively.
💡
Conclusion & Impact:The negative predictive value of a normal appearing duodenal mucosa was found 90% arid pozitif prediktif value %68.
🔬Design:Research Article
📍Scope:2000 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim of this study, to determine the significance and rate of duodenal pathology during Eosophagogastroduodenoscopy (EGDs) in childhood and relation to pathological diagnosis. We evaluated 227 diagnostic EGDs with duodenal biopsies performed in consecutive infants (mean age; 6 month to 20 years; average age, 10.6 years) during the 24-month period from August 2000 to August 2002 retrospectively. Indications of EGDs included chronic abdominal pain (n=116; 52%), suspected gluten sensitive enteropathy (GSE) (n=37; 16%), upper GIS bleeding (n=34; 15%), evaluated for portal hypertension (n=24; 11%) and vomiting (n=14; 6%). Duodenal pathology was found in 39 of 227 patients (17%). Pathologic examination revealed villous atrophy (18 patients; 46%), bulbitis (15 patients; 38%), duodenitis (n=11; 28%), lymphocytes infiltration (n=7; 18%), and duodenal ulcer (n=2; 5%). Of 20 patients diagnosed GSE (54%), followed by Helicobacter pylori infections 13 patients (35%), duodenal ulcer 2 patients and giardiasis 1 patient respectively. Endoskopic duodenal pathology was very rare condition among the patients with portal hypertension (n=3; 0.8%). In cases with GSE mucosal flatting was found to be the most significantly sign (n=10; 50%), followed by granularity (n=5; 20%), mucosal fissured (n=3; 15%) and normal appearance (n=3; 15%) respectively. Duodenal mucosal pathologies were detected 14 of 124 patients by normal EGDs during study period. In this study we found that negative predictive value of 87%, positive predictive value %65 for gastric pathology. The negative predictive value of a normal appearing duodenal mucosa was found 90% arid pozitif prediktif value %68.

Özet

Bu çalışmanın amacı çocuklarda üst gastrointestinal sistem endoskopilerinde duodenal patolojilerin oranı ve önemi ve patolojik tanıyla ilişkisini saptamaktır. Ağustos 2000-Ağustos 2002 tarihleri arasında 24 aylık sürede tanısal amaçlı yapılan ve rutin duodenal biyopsi alınan 227 üst gastrointestinal sistem endoskopisi değerlendirildi (6 ay-20 yaş arası, ortalama 10.6 yaş). Endoskopi kronik karın ağrısı, (n=116; %52), gluten sensitive enteropati (GSE) şüphesi (n=37; 16), üst GIS kanaması (n=34; %15), portal hipertansiyon için değerlendirme ( n=24; %11) ve kusma (n=14; %6) nedeni ile yapıldı. Histolojik olarak duodenal patoloji 39 hastada saptandı (%17). Patolojik incelemede villöz atrofi (n=18; %46), bulbit (n=15; %38), duodenit (n=11; %28), lenfosit infiltrasyonu (n=7; %18) ve duodenal ülser (n=2; %5) saptandı. 20 hastaya (%54) GSE, 13 hastaya (%35) Helicobacter pylori enfeksiyonu, 2 hastaya duodenal ülser ve bir hastaya giardiyazis tanısı konuldu. Portal hipertansiyonlu hastalar arasında endoskopik olarak duodenal patoloji çok nadir bulundu (n=3; %0.8). GSE'Iİ hastalarda mukoza kıvrımlarının düzleşmesi en önemli bulgu olarak tespit edildi (n=10; %50), Bunu sırasıyla granülarite (n=5; %20), mukozal fissürler (n=3; %15) ve normal görünüm (n=3; %15) izliyordu. Üst GIS endoskopisinde duodenumu normal olarak görülen 124 olgunun 14'ünde duodenal mukozal patoloji tespit edildi. Mide patolojilerinde endoskopinin pozitif tahmin değeri %65, negative tahmin değeri %87, normal görünümlü duodenal mukoza için pozitif tahmin değeri %68, negative tahmin değeri %90 olarak bulundu.

🔖

Cite This Article

TÜMGÖR, G., YAĞCI, R. V., ÖZEN, S., AYDOĞDU, S., ARIKAN, Ç., AKMAN, A. S., ÖZGENÇ, F. (2022). Duodenal pathologies in pediatric patients undergoing upper gastrointestinal endoscopy adolescents. Ege Pediatri Bülteni, Cilt: 11 - Sayı: 2, 107–112. https://ajindex.com/articles/495807

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Huang IF, Wu TC, Wang KS, Hwang B, Hsieh KS. Upper gastrointestinal endoscopy in children with upper gastrointestinal bleeding. J Chin Med Assoc 2003; 66(5): 271-275
  2. Shudo R, Yazaki Y, Sakurai S, et al. Duodenal erosions, a common and distinctive feature of portal hypertensive duodenopathy. Am J Gastroenterol 2002; 97(4): 867-873
  3. Oderda G, Forni M, Farina L, Dell'Olio D, Ansaldi N. Duodenitis in children: clinical, endoscopic, and pathological aspects. Gastrointest Endosc 1987; 33(5): 366-369
  4. Dickey W, Hughes D. Prevalence of celiac disease and its endoscopic markers among patients having routine upper gastrointestinal endoscopy. Am J Gastroenterol 1999; 94: 2182Ð2186
  5. Szajewska H, Albrecht P, Ziolkowski J, et al. Intramural duodenal hematoma: an unusual complication of duodenal biopsy sampling. J Pediatr Gastroenterol Nutr 1993; 16: 331Ð333
  6. Rawashdeh MO, Abu-Farsakh N, al-Jaberi TM. Paediatric upper gastro-intestinal endoscopy in developing countries. Ann Trop Paediatr 1996; 16(4): 341-346
  7. Ayoola EA, Nanda VJ, Gadour MO, Elamin AK. Upper gastrointestinal diseases in Saudi Arabian children Trop Gastroenterol 1999; 20(3): 137-139
  8. Quak SH, Lam SK, Low PS. Upper gastrointestinal endoscopy in children. Singapore Med J 1990; 31(2): 123-126. 9. ztŸrk Y, BŸyŸkgebiz B, Arslan N, zer E. Tekrarlayan karÝn aÛrÝsÝnda Ÿst gastrointestinal sistem endoskopi bulgularÝ
  9. Milli Pediatri Kongresi, 21-23 Ekim 2003, Üstanbul, TŸrkiye
  10. Ashorn M, Maki M, Ruuska T, et al. Upper gastrointestinal endoscopy in recurrent abdominal pain of childhood. J Pediatr Gastroenterol Nutr 1993; 16(3): 273-277
  11. Kori M, Gladish V, Ziv-Sokolovskaya N, et al. The Significance of Routine Duodenal Biopsies in Pediatric Patients Undergoing Upper Intestinal Endoscopy. J Clin Gastroenterol 2003; 37(1): 39-41
  12. Leopold ER, Bornstein JA, Wensett D, et al. Utility of routine duodenal biopsies during esophagogastroduodenoscopy, abstract. In 1st world conference of pediatric gastroenterology and nutrition. August 2000. Boston, USA
  13. Walker S, Ruhl U. 4199 biopsies from the endoscopic normal lower duodenum. Z Gastroenterol 2003; 41(1): 69-74
  14. Brocchi E, Tomassetti P, Misitano B, et al. Endoscopic markers in adult coeliac disease. Dig Liver Dis 2002; 34(3): 177-182
  15. Prakash J, Agrawal BK. Upper gastrointestinal mucosal lesions in chronic renal failure. Indian J Gastroenterol 1991; 10(4): 131-132
  16. Kawamoto H, Himeno S, Shinomura Y, et al. Clinical and h