Journals / Ege Pediatri Bülteni / 2007 / Cilt: 14 - Sayı: 3

A comparison of trimethoprim-sulfamethoxazole, cephalexin and amoxicillin as prophylaxis for acute pyelonephritis in children

Akut piyelonefrit olan çocuklarda trimetoprim / sülfametoksazol, sefaleksin ve amoksisilin profilaksilerinin etkinliğinin karşılaştırılması

Pages
141–144
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, in this study trimethoprim-sulfamethoxazole, cephalexin or amoxicillin were found to be similar effect in preventing UTI in children.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:A cute pyelonephritis (PN) is an important condition in children and may lead to renal scarring with later risk of hypertension and renal insufficiency.
📊
Key Findings & Data:We performed a retrospective of analysis of 101 patients (79% girls and 21% boys).
💡
Conclusion & Impact:In conclusion, in this study trimethoprim-sulfamethoxazole, cephalexin or amoxicillin were found to be similar effect in preventing UTI in children.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

A cute pyelonephritis (PN) is an important condition in children and may lead to renal scarring with later risk of hypertension and renal insufficiency. The aim of the study was to assess the efficacy of prophylaxis in PN in the pediatric age group. We performed a retrospective of analysis of 101 patients (79% girls and 21% boys). Aged from 1 months-11,5 years at the time of PN. Mean follow-up period was 11,6±4,7 months (6-31 months). After PN were treated, trimethoprim-sulfamethoxazole, cephalexin or amoxicillin were given to the patients. All patients were followed for efficacy of prophylaxis. Ultrasonography was normal in 88% in children. DMSA studies showed scars in %14 renal units. Reflux was diagnosed in 47 renal units. The frequency of urinary tract infections (UTI) among group during prophylaxis was not statistically significant. In conclusion, in this study trimethoprim-sulfamethoxazole, cephalexin or amoxicillin were found to be similar effect in preventing UTI in children.

Özet

Amaç: Çocuklarda akut piyelonefrit (APN) renal skar ve geç dönemde hipertansiyon ve böbrek yetmezliği geliştirme olasılığı nedeniyle önemlidir. Bu nedenle hastaların erken dönemde değerlendirilmesi ve oluşabilecek yeni idrar yolu enfeksiyonlarının (İYE) önlenmesi için profilaktik antibiyotik kullanılması önemlidir.Gereç-yöntem: Çalışmamızda 101 hasta retrospektif olarak değerlendirildi. Hastalara APN tedavisi sonrasında trimetoprim/sülfo-metoksazol, amoksisilin veya sefadroksil verildi.Bulgular: Çalışmaya dahil edilen hastaların %79’u kız, %21’i erkekti. Hastaların yaşları 1 ay ile 11,5 yaş arasındaydı. Ortalama izlem ayı 11,65±4,76 aydı (6 ay-31 ay). Seksendokuz hastanın (%88) üriner sistem US incelemesi normal olarak değerlendirildi. Enfeksiyondan 6 ay sonra yapılan DMSA sintigrafisinde APN döneminde hipoaktif alan gözlenen hastaların %14’ünde skar saptandı. Kırkyedi renal ünitede vezikoüreteral reflü saptandı. Profilaksi için kullanılan ilaçlar karşılaştırıldığında 3 ilaç grubunda da İYE sıklığı için istatistiksel olarak anlamlı fark saptanmadı (p>0,05). Her 3 grupta da profilaktik kullanılan ilaçların uygulanma süresi ve hastaların izlem süreleri arasında istatistiksel olarak anlamlı farka rastlanmadı (p>0,05).Sonuç: Çalışmamızla çocuklarda profilaksi amacıyla kullanılan üç ilacın da İYE gelişimini benzer oranda önlediği gösterilmiş

🔖

Cite This Article

ASLAN, S., ARIKAN, F. İ., ACAR, B., DALLAR, Y. (2022). A comparison of trimethoprim-sulfamethoxazole, cephalexin and amoxicillin as prophylaxis for acute pyelonephritis in children. Ege Pediatri Bülteni, Cilt: 14 - Sayı: 3, 141–144. https://ajindex.com/articles/495697

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (1)

  1. Goonasekera CDA, Dillon MJ. Hypertension in reflux nephropathy. BJU Int 1999;83:1-12. 4. Goonasekera CDA, Shah V, Wade AM, Barrat TM, Dillon MJ. 15 year-follow-up of renin and blood pressure in reflux nephropathy. Lancet 1996;347:640-3. 5. Elo J, Tallgren LG, Sarna S, Alfthan O, Stenstrom R. The role of vesicoureteral reflux in pediatric urinary tract infection. Scand J Urol Nephrol 1981;15:243-8. 6. Rusthton HG, Majd M, Jantausch B. Renal scarring following reflux and nonreflux pyelonephritis: evaluation with 99m-technetium-dimercaptosuccinic acid scintigraphy. J Urol 1992;147:1327-32. 7. Beetz R. May we go on with antibacterial prophylaxis for urinary tract infections? Pediatr Nephrol 2006;21:5-13. 8. International Reflux Study Committee. Medical versus surgical treatment of primary vesicoureteral reflux. Pediatrics 1981;67:392-400. 9. Behrman, Kliegman, Jenson. Urinary tract infection. Nelson Textbook of Pediatrics 16th edt. Chapter 546, 1621-4. 10. Smellie JM, Gruneberg RN, Bantock HM; Prescod N. Prophylactic co-trimoxazole and trimethoprim in the management of urinary tract infection in children. Pediatr Nephrol. 1988;2:12-7. 11. Seracini D, Materassi M, Danti A. Non-comparative open study of the efficacy and tolerance of cefaclor in the prevention of urinary tract infections in children Pediatr Med Chir. 1996;18:383-5. 12. Rudenko N, Dorofeyev A. Prevention of recurrent lower urinary tract infections by long-term administration of fosfomycin trometamol. Double blind, randomized, parallel group, placebo controlled study. Arzneimittelforschung. 2005;55:420-7. 13. Belet N, İşlek İ, Belet U, Sunter AT, Küçüködük S. Comparison of trimethoprim-sulfamethoxazole, cephadroxil and cefprozil as prophylaxis for recurrent urinary tract infections in children. J Chemother 2004; 16:77-81.