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Journals / Ege Klinikleri Tıp Dergisi / 2020 / Cilt: 58 - Sayı: 3

Comparison of the Tissue Trauma Markers Following Total Laparoscopic Hysterectomy vs Total Abdominal Hysterectomy

Laparoskopik ve Abdominal Histerektomide Doku Travma Belirteçlerinin Karşılaştırılması

Eren AKBABA
Burak SEZGİN
Nilgün Ö. TURHAN
Kazım HANÇER
Pages
356–363
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further studies conducted with inflammatory markersother than PTX-3 and NLR are required to elucidate the choice of surgerytechnique in similar patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To compare abdominal and laparoscopic techniques of hysterectomyin terms of the surgery-induced trauma with measuring serum Pentraxin-3 (PTX3) level and neutrophil to lymphocyte ratio (NLR).Materials and Methods: In this study, preoperative and postoperative bloodsamples were used to compare the change at the level of PTX-3 and NLR inorder to evaluate the inflammatory response in 40 patients, of whom, 20 hadexperienced Total Laparoscopic Hysterectomy (TLH) + Bilateral SalpingoOophorectomy (BSO) and 20 had experienced Total Abdominal Hysterectomy(TAH + BSO).Results: Based on our comparison, change in PTX-3 level in TLH+BSO group 4.5ng/mL (0.3-18.6) was slightly higher than that of TAH+BSO group 3.0 ng/mL (0.0-18.1), but the difference was not statistically significant (p =0.429).
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Key Findings & Data:Likewise, theincrease in the NLR in TLH+BSO group 3.5 (1.2-19.4) was slightly higher than thatof TAH+BSO group 2.8 (-0.3-8.8), but not to a statistically significant extent (p =0.114).Conclusion: When we use the inflammatory markers of PTX-3 and NLR, therewas no significant difference between the two surgery techniques in terms ofdegree of tissue trauma.
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Conclusion & Impact:Further studies conducted with inflammatory markersother than PTX-3 and NLR are required to elucidate the choice of surgerytechnique in similar patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: To compare abdominal and laparoscopic techniques of hysterectomyin terms of the surgery-induced trauma with measuring serum Pentraxin-3 (PTX3) level and neutrophil to lymphocyte ratio (NLR).Materials and Methods: In this study, preoperative and postoperative bloodsamples were used to compare the change at the level of PTX-3 and NLR inorder to evaluate the inflammatory response in 40 patients, of whom, 20 hadexperienced Total Laparoscopic Hysterectomy (TLH) + Bilateral SalpingoOophorectomy (BSO) and 20 had experienced Total Abdominal Hysterectomy(TAH + BSO).Results: Based on our comparison, change in PTX-3 level in TLH+BSO group 4.5ng/mL (0.3-18.6) was slightly higher than that of TAH+BSO group 3.0 ng/mL (0.0-18.1), but the difference was not statistically significant (p =0.429). Likewise, theincrease in the NLR in TLH+BSO group 3.5 (1.2-19.4) was slightly higher than thatof TAH+BSO group 2.8 (-0.3-8.8), but not to a statistically significant extent (p =0.114).Conclusion: When we use the inflammatory markers of PTX-3 and NLR, therewas no significant difference between the two surgery techniques in terms ofdegree of tissue trauma. Further studies conducted with inflammatory markersother than PTX-3 and NLR are required to elucidate the choice of surgerytechnique in similar patients.

Özet

Amaç: Pentraxin-3 (PTX-3) seviyesi ve nötrofil/lenfosit oranını ölçerek, cerrahi işlemin neden olduğu doku travması bakımından abdominal ve laparoskopik histerektominin karşılaştırılması. Materyal ve Metod: 20 Total laparoskopikhisterektomi + bilateral salpingo ooferektomi (TLH+BSO) ve 20 total abdominal histerektomi + bilateral salpingo ooferektomi (TAH + BSO) olmak üzere toplam 40 hasta çalışmaya dahil edildi. Tüm hastalardan operasyon öncesi ve sonrası dönemde kan örnekleri toplanarak Pentraxin-3 (PTX-3) seviyesi ve nötrofil/ lenfosit oranı belirlendi. Elde edilen veriler ile iki grup arasında karşılaştırmalı analizler yapıldı. Bulgular: Yaptığımız analizlerin sonucunda, PTX-3 seviyesindeki değişim TLH+BSO grubunda (4.5 ng/mL (0.3-18.6)) TAH+BSO grubuna göre (3.0 ng/mL (0.0-18.1)) istatistiksel anlam olmamasına rağmen hafif yüksek bulunmuştur (p =0.429). Benzer şekilde, nötrofil/ lenfosit oranındaki artış TLH+BSO grubunda (3.5 (1.2-19.4)) TAH+BSO grubuna göre (2.8 (-0.3-8.8)) )) istatistiksel anlam olmamasına rağmen hafif yüksek bulunmuştur (p = 0.114). Sonuç: İnflamatuar belirteçler olan PTX-3 ve nötrofil/ lenfosit oranı incelendiğinide, iki cerrahi teknik arasında doku travma dereceleri bakımından anlamlı fark gözlenmemiştir. İleride yapılacak olan PTX-3 ve nötrofil/ lenfosit oranı dışındaki inflamatuar belirteçlerin değerlendirilmesi benzer hastalarda cerrahi teknik seçimini aydınlatmaya katkı sağlayacaktır.

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Cite This Article

AKBABA, E., SEZGİN, B., TURHAN, N. Ö., HANÇER, K. (2022). Comparison of the Tissue Trauma Markers Following Total Laparoscopic Hysterectomy vs Total Abdominal Hysterectomy. Ege Klinikleri Tıp Dergisi, Cilt: 58 - Sayı: 3, 356–363. https://ajindex.com/articles/495667

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