Journals / Ege Klinikleri Tıp Dergisi / 2020 / Cilt: 58 - Sayı: 3

The effect of short bowel and related factors on survival in Acute Mesenteric Ischemia

Akut mezenter iskemide kısa bağırsak ve ilişkili faktörlerin sağkalıma etkisi

Pages
289–294
Publication Date
2022-10-11
DOI
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A high total bilirubin level was also associated with a significantlyshorter duration of survival (p=0.020).Conclusion: The findings of the present study suggest that the preservation ofthe ileocecal valve during surgery, a remaining small intestinal length longerthan 200 cm, normal total bilirubin levels, and absence of perforation may beassociated with an improved survival rate in patients undergoing bowelresection for AMI.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Acute mesenteric ischemia (AMI), which is a disease of thegastrointestinal system and its vasculature, is associated with a high risk ofmorbidity and mortality.
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Key Findings & Data:Short bowel syndrome (SBS), which markedly increasesmorbidity and mortality rates, is among the most important problems inpatients with AMI who undergo resection of large sections of the bowel.Methods:The data of 42 patients with occlusive AMI who underwent surgicalintervention were analyzed retrospectively.
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Conclusion & Impact:A high total bilirubin level was also associated with a significantlyshorter duration of survival (p=0.020).Conclusion: The findings of the present study suggest that the preservation ofthe ileocecal valve during surgery, a remaining small intestinal length longerthan 200 cm, normal total bilirubin levels, and absence of perforation may beassociated with an improved survival rate in patients undergoing bowelresection for AMI.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Acute mesenteric ischemia (AMI), which is a disease of thegastrointestinal system and its vasculature, is associated with a high risk ofmorbidity and mortality. Short bowel syndrome (SBS), which markedly increasesmorbidity and mortality rates, is among the most important problems inpatients with AMI who undergo resection of large sections of the bowel.Methods:The data of 42 patients with occlusive AMI who underwent surgicalintervention were analyzed retrospectively. Demographic data, length of smallintestine after resection, removal of the ileocecal valve, preoperative laboratorytest results (white blood cell(WBC) count, bilirubin level, amylase level, survivalstatus and duration were recorded.Results: A total of 42 patients (17 males and 25 females) were included into thestudy. The mean age was 71.95 ± 11.83 years. The mean follow-up period was19.17 ± 27.77 months. The mean remaining bowel length was 222.02±126.51cm. There was no statistically significant difference in mortality rates betweenpatients with a length of remaining small intestine shorter or longer than 200cm. The patients with a high total bilirubin level had a higher rate of mortalitythan those with a normal total bilirubin level (61.9% vs. 28.57%,respectively)(p=0.03). The mean duration of survival was significantly shorter inpatients who underwent ileocecal valve resection compared with those who didnot (p=0.021). A high total bilirubin level was also associated with a significantlyshorter duration of survival (p=0.020).Conclusion: The findings of the present study suggest that the preservation ofthe ileocecal valve during surgery, a remaining small intestinal length longerthan 200 cm, normal total bilirubin levels, and absence of perforation may beassociated with an improved survival rate in patients undergoing bowelresection for AMI.

Özet

Amaç: Gastrointestinal sistemin ve damarlarının bir hastalığı olan akutmezenterik iskemi (AMI), yüksek morbidite ve mortalite riski taşır. Morbidite ve mortalite oranlarını belirgin şekilde artıran kısa bağırsak sendromu (SBS),bağırsağın geniş bölümlerinin eksizyonu uygulanan AMI'li hastalarda en önemli sorunlardan birtanesidir. Gereç ve yöntem: Cerrahi müdahale uygulanan 42 damar oklüzyonu olan AMI hastasının verileri retrospektif olarak incelendi. Demografik veriler, rezeksiyon sonrası incebağırsak uzunluğu, ileoçekal valvin çıkarılması, preoperatif laboratuvar test sonuçları (beyaz kan hücresi (WBC) sayısı, bilirubin seviyesi, amilaz seviyesi, sağkalım durumu ve süresi) kaydedildi. Bulgular: Toplam 42 hasta (17 erkekve 25 kadın) çalışmaya dahil edildi. Yaş ortalaması 71,95 ± 11,83 idi. Ortalama takip süresi 19.17 ± 27.77 ay idi. Ortalama kalan bağırsak uzunluğu 222.02 ± 126.51 cm idi. Kalan bağırsak uzunluğu 200 cm'den kısa veya daha uzun olan hastalar arasında mortalite oranları arasında istatistiksel olarak anlamlı bir fark yoktu. Toplam bilirubin düzeyi yüksek olan hastalar, normal toplam bilirubin düzeyi olanlara göre daha yüksek mortalite oranına sahipti (sırasıyla %61.9'a karşılık %28.57) (p=0.03). İleoçekal kapak rezeksiyonu yapılan hastalarda ortalama sağkalım süresi ileoçekal kapak rezeksiyonu yapılmayan hastalara göre anlamlı derecede daha kısaydı (p = 0.021). Yüksek toplam bilirubin seviyesi de anlamlı derecede daha kısa sağ kalım süresi ile ilişkili bulunmuştur (p = 0.020). Sonuç: Bu çalışmanın bulguları, ameliyat sırasın da ileoçekal valvin korunmasının, 200 cm'den daha uzun kalan ince bağırsak uzunluğunun, normal total bilirubin düzeylerinin ve perforasyonun yokluğunun bağırsak rezeksiyonu uygulanan AMİ li hastalarda daha iyi bir sağ kalım oranı ile ilişkili olabileceğini düşündürmektedir.

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Cite This Article

GÜL, M. O., UZUNOĞLU, H. (2022). The effect of short bowel and related factors on survival in Acute Mesenteric Ischemia. Ege Klinikleri Tıp Dergisi, Cilt: 58 - Sayı: 3, 289–294. https://ajindex.com/articles/495662

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