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Journals / Ege Klinikleri Tıp Dergisi / 2021 / Cilt: 59 - Sayı: 1

Mitoepigenetics and its Role in Neurodegenerative Diseases

Mitoepigenetik ve Nörodejeneratif Hastalıklardaki Rolü

Ayşegül DEMİRTAŞ
Tuba GÖKDOĞAN EDGÜNLÜ
Pages
1–5
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Here, the effects of mitoepigenetic changes on certain neurodegenerative diseases are reviewed in the light of available information.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Mitoepigenetic is epigenetic mechanisms that occur within the mitochondrial organelle.
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Key Findings & Data:Mitoepigenetic regulations are mitochondrial DNA (mtDNA) methylation / hydroxymethylation, mitochondrial nucleoid modifications, mitochondrial RNA (mtRNA) modifications, and modulation of non-coding RNAs (ncRNA) originating from nuclear DNA (nDNA) and mtDNA.
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Conclusion & Impact:Here, the effects of mitoepigenetic changes on certain neurodegenerative diseases are reviewed in the light of available information.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Mitoepigenetic is epigenetic mechanisms that occur within the mitochondrial organelle. Mitoepigenetic regulations are mitochondrial DNA (mtDNA) methylation / hydroxymethylation, mitochondrial nucleoid modifications, mitochondrial RNA (mtRNA) modifications, and modulation of non-coding RNAs (ncRNA) originating from nuclear DNA (nDNA) and mtDNA. Mitoepigenetic changes are thought to affect mitochondrial dysfunction and underlie many diseases. Here, the effects of mitoepigenetic changes on certain neurodegenerative diseases are reviewed in the light of available information.

Özet

Mitoepigenetik, mitokondri organeli içerisinde meydana gelen epigenetik mekanizmalardır. Mitoepigenetik düzenlemeler; mitokondriyal DNA (mtDNA) metilasyonu/hidroksimetilasyonu, mitokondriyal nükleoid modifikasyonları, mitokondriyal RNA (mtRNA) modifikasyonları ve nükleer DNA’dan (nDNA) ve mtDNA’dan köken alan kodlanmayan RNA’ların (ncRNA) modülasyonları olarak sınıflandırılmaktadır. Mitoepigenetik değişikliklerin, mitokondriyal disfonksiyona etki ettiği ve birçok hastalığa zemin oluşturduğu düşünülmektedir. Burada, mitoepigenetik değişikliklerin belirli nörodejeneratif hastalıklar üzerindeki etkileri mevcut bilgiler ışığında derlenmiştir.

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Cite This Article

DEMİRTAŞ, A., EDGÜNLÜ, T. G. (2022). Mitoepigenetics and its Role in Neurodegenerative Diseases. Ege Klinikleri Tıp Dergisi, Cilt: 59 - Sayı: 1, 1–5. https://ajindex.com/articles/495626

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