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Journals / Ege Klinikleri Tıp Dergisi / 2021 / Cilt: 59 - Sayı: 2

Evaluation of the Effectiveness of Preoperative Breast Ultrasound and Mammography to Detect Axillary Lymph Node Metastasis in Patients Undergoing Sentinel Lymph Node Biopsy Due to Breast Carcinoma

Meme Karsinomu Nedeniyle Sentinel Lenf Nodu Biyopsisi Yapılan Hastalarda Preoperatif Meme Ultrason ve Mamografi İle Aksiller Bölgenin Değerlendirilmesi

Serkan KARAISLI
Murat Kemal ATAHAN
Kürşat YEMEZ
Gülten SEZGİN BENER
Pages
1–6
Publication Date
2022-10-11
DOI
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⚡ TL;DR(Too Long; Didn't Read)

A statistically significant difference was found between the groups in terms of TNM stage (p

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Sentinel lymph node biopsy (SLNB) is a routine procedure for axillary staging in clinically negative breast cancer patients.
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Key Findings & Data:Materials and Methods: Ninety-five patients who underwent SLNB with methylene blue and / or Technetium-99m Sulfur Colloid for breast cancer were included in the study.
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Conclusion & Impact:A statistically significant difference was found between the groups in terms of TNM stage (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: Sentinel lymph node biopsy (SLNB) is a routine procedure for axillary staging in clinically negative breast cancer patients. Sentinel lymph node (SLN) is the only focus in axillary lymph metastasis in most patients. In this study, we aimed to investigate the reliability of preoperative breast ultrasonography and mammography in patients who underwent SLNB. Materials and Methods: Ninety-five patients who underwent SLNB with methylene blue and / or Technetium-99m Sulfur Colloid for breast cancer were included in the study. Patient files were analyzed retrospectively. The study group was divided into two groups as premenopausal and postmenopausal. Preoperative breast ultrasound and mammography, postoperative SLN status, age, tumor side and quadrant distribution, surgical treatment type, primary tumor size, axillary lymph node metastasis status, TNM stage, hormone receptor status, c-erbB2 gene status, Ki-67 proliferation index rate was recorded as variables and compared between groups. Results: The mean age of the patients was 53.05 ± 9.86 (29-81). SLN was found benign in 22 (23.2%) of the patients and SLN was found to be malign in 73 (76.8%). No correlation was obtained between the patient's age, tumor size, tumor localization, hormone receptor positivity / negativity, Ki 67, p53 status and SLN metastasis (p> 0.05). A statistically significant difference was found between the groups in terms of TNM stage (p

Özet

Giriş: Klinik olarak aksilla negatif meme kanseri hastalarında sentinel lenf nodu biyopsisi (SLNB) aksiller evreleme için rutin uygulanan bir prosedürdür. Sentinel lenf nodu (SLN) hastaların önemli bir kısmında aksiller lenf metastazında tek odaktır. Biz de çalışmamızda, hastanemizde SLNB uygulanan hastalarda, preoperatif dönemde yapılan meme ultrasonografi ve mamografinin güvenilirliğini araştırmayı amaçladık. Gereç ve Yöntem: Çalışmaya meme kanseri nedeniyle metilen mavisi ve/veya Teknesyum-99m Sülfür Kolloid ile SLNB uygulanan 95 hasta dahil edildi. Hasta dosyaları retrospektif olarak incelendi. Çalışma grubu, premenopozal ve postmenopozal olarak iki gruba ayrıldı. Preoperatif yapılan meme ultrason ve mamografisi ile postoperatif SLN durumu, yaş, tümör taraf ve kadran dağılımı, uygulanan cerrahi tedavi şekli, primer tümör büyüklüğü, aksiller lenf nodu metastaz durumu, TNM evresi, hormon reseptör durumu, c-erbB2 geni durumu, Kİ-67 proliferasyon indeksi oranı değişkenler olarak kaydedilip gruplar arasında karşılaştırıldı. Bulgular: Hastaların yaş ortalaması 53,05±9,86 (29-81) idi. Hastaların 22’sinde (%23,2) SLN benign ve 73’ünde (%76,8) SLN malign saptandı. Hastanın yaşı, tümör çapı, tümör lokalizasyonu, hormon reseptör pozitifliği/negatifliği, Ki 67 ve p53 durumu ile SLN metastazı arasında istatistiksel anlamlı sonuç elde edilmedi (p>0,05). TNM evresi açısından gruplar arasında istatistiksel olarak anlamlı fark bulundu (p

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Cite This Article

KARAISLI, S., ATAHAN, M. K., YEMEZ, K., BENER, G. S. (2022). Evaluation of the Effectiveness of Preoperative Breast Ultrasound and Mammography to Detect Axillary Lymph Node Metastasis in Patients Undergoing Sentinel Lymph Node Biopsy Due to Breast Carcinoma. Ege Klinikleri Tıp Dergisi, Cilt: 59 - Sayı: 2, 1–6. https://ajindex.com/articles/495580

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References (11)

  1. Gewefel H, Salhia B. Breast cancer in adolescent and young adult women. Clin Breast Cancer 2014; 14(6): 390-395
  2. DeSantis CE, Ma J, Gaudet MM, et al. Breast cancer statistics, 2019. CA Cancer J Clin 2019;69:438–451
  3. Apple SK. Sentinel lymph node in breast cancer: review article from a pathologist’s point of view. J Pathol Transl Med 2016;50:83–95
  4. Cavalli LR, Cavalli IJ. Molecular classification and prognostic signatures of breast tumors. In: Urban C, Rietjens M, El-Tamer M, Sacchini V (eds) Oncoplastic and reconstructive breast surgery. Springer, Cham; 2019, pp.129–138
  5. Prat A, Pineda E, Adamo B, Galvan P, Fernandez A, Gaba L, etal. Clinical implications of the intrinsic molecular subtypes of breast cancer. Breast 2015;24(2):S26-S35
  6. Gradishar WJ, Anderson BO, Balassanian R, et al. NCCN Guidelines Insights: Breast Cancer, Version 1.2017. J Natl Compr Canc Netw 2017; 15(4): 433-451. 7.Bouquet de Jolinière J, Major A, Khomsi F, Ben Ali N, Guillou L,Feki A. The Sentinel Lymph Node in Breast Cancer: Problems Posed by Examination During Surgery. A Review of Current Literature and Management. Front Surg 2018; 5: 56
  7. Wang K, Ren Y, Li H, et al. Comparison of Clinicopathological Features and Treatments between Young (≤ 40 Years) and Older (> 40 Years) Female Breast Cancer Patients in West China: A Retrospective, Epidemiological, Multicenter, Case Only Study. PLoS One 2016;11:e0152312 9. Coates AS, Winer EP, Goldhirsch A, et al. Tailoring therapies – improving the management of early breast cancer: Stgallen international expert consensus on the primary therapy of early breast cancer 2015. Ann Oncol 2015;26(8):1533-1546 10. Zahoor S, Haji A, Battoo A, Qurieshi M, Mir W, Shah M. Sentinel Lymph Node Biopsy in Breast Cancer: A Clinical Review and Update. J Breast Cancer 2017;20(3):217-227
  8. He L, Zhao S, Liu M, Su Z, Ren Y, Song Y. The reciprocal influences of prognosis between two types of surgical interventions and early breast cancer patients with diverse luminal subtypes: A metaanalysis. Medicine (Baltimore) 2019; 98(11): e14912
  9. Özçınar B, Güler SA, Kocaman N, Özkan M, Güllüoğlu BM, Özmen V. Complications Associated with Loco-Regional Treatment of Breast Cancer and Their Impact on Quality-of-Life. Eur J Breast Health 2018;15(1): 51-58
  10. Üreyen O, Çavdar DK, Adıbelli ZH, İlhan E. Axillary metastasis in clinically node-negative breast cancer. J Egypt Natl Canc Inst 2018;30(4): 159-163
  11. Ding J, Jiang L, Wu W. Predictive Value of Cl