SavedAdd your journal

Journals / Ege Klinikleri Tıp Dergisi / 2021 / Cilt: 59 - Sayı: 1

The Effect of Vaginal Estrogen Administration on Endometrial Morphology and Uterine Artery Doppler in Postmenopausal Women

Postmenopozal Kadınlarda Vajinal Östrojen Uygulamasının Endometrial Morfoloji ve Uterin Arter Doppler Üzerine Etkisi

Mehmet Murat IŞIKALAN
Şükran DOĞRU
Müzeyyen GÜNEŞ
Pages
1–6
Publication Date
2022-10-11
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: The decrease in LH value and increase in estradiol values at the 6th month of treatment were found to be significant (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: We aimed to investigate the effect of 17β-estradiol vaginal tablet on endometrial morphology and uterine artery pulsatility and resistance indices in postmenopausal women.
📊
Key Findings & Data:Material and method: This is a prospective study involving 40 postmenopausal women who were admitted to the Menopause Outpatient Clinic of the SSK Ankara Maternity and Gynecology Training Hospital and who could not receive systemic hormone replacement for atrophic vaginitis or any other reason.
💡
Conclusion & Impact:Results: The decrease in LH value and increase in estradiol values at the 6th month of treatment were found to be significant (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: We aimed to investigate the effect of 17β-estradiol vaginal tablet on endometrial morphology and uterine artery pulsatility and resistance indices in postmenopausal women. Material and method: This is a prospective study involving 40 postmenopausal women who were admitted to the Menopause Outpatient Clinic of the SSK Ankara Maternity and Gynecology Training Hospital and who could not receive systemic hormone replacement for atrophic vaginitis or any other reason. Participants were questioned in terms of vaginal complaints (dryness, itching, burning-pain, dyspareunia) before treatment. Hormone profile, cervicovaginal smear, pelvic ultrasonography, uterine artery Doppler and endometrial biopsy sampling were performed. 17β-estradiol was given to the patients as a vaginal tablet for two weeks. The patients were evaluated in terms of treatment efficacy at 3 and 6 months. Results: The decrease in LH value and increase in estradiol values at the 6th month of treatment were found to be significant (p

Özet

Amaç : Bu çalışmada, postmenopozal kadınlarda, 17β- östradiol vajinal tabletin endometrial morfoloji ve uterin arter pulsatilite ve rezistans indeksleri üzerindeki etkisinin incelenmesi amaçlandı. Materyal metod: Bu çalışma, SSK Ankara Doğumevi ve Kadın Hastalıkları Eğitim Hastanesi Menopoz Polikliniğine başvuran,atrofik vajinit veya herhangi bir nedenle sistemik hormon replasmanı yapılamayan, 40 postmenopozal kadını içeren prospektif bir çalışmadır.Hastalar tedavi öncesinde vajinal yakınmalar (kuruluk, kaşınma, yanma-acıma, disparoni) açısından sorgulandı. Hormon profili, servikovajinal smear, pelvik ultrasonografi, uterin arter Doppler ve endometrial biyopsi örneklemesi yapıldı. Hastalara iki hafta boyunca vajinal yoldan 17β-östradiol tablet verildi. Hastalar 3. ve 6.ayda tedavi etkinliği açısından değerlendirildi. Bulgular: Tedavinin 6.ayındaki LH değerindeki düşüş ve östradiol değerlerindeki yükselme anlamlı bulundu (p

🔖

Cite This Article

IŞIKALAN, M. M., DOĞRU, Ş., GÜNEŞ, M. (2022). The Effect of Vaginal Estrogen Administration on Endometrial Morphology and Uterine Artery Doppler in Postmenopausal Women. Ege Klinikleri Tıp Dergisi, Cilt: 59 - Sayı: 1, 1–6. https://ajindex.com/articles/495579

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Soares CN. Depression and Menopause: An Update on Current Knowledge and Clinical Management for this Critical Window. Med Clin North Am. 2019
  2. 103(4):651-67. 2.Polo-Kantola P, Rantala MJ. Menopause, a curse or an opportunity? An evolutionary biological view. Acta Obstet Gynecol Scand. 2019
  3. 98(6):687- 8. 3.Bansal R, Aggarwal N. Menopausal Hot Flashes: A Concise Review. J Midlife Health. 2019
  4. 10(1):6-13. 4.Caruso D, Masci I, Cipollone G, Palagini L. Insomnia and depressive symptoms during the menopausal transition: theoretical and therapeutic implications of a self-reinforcing feedback loop. Maturitas. 2019
  5. Katon JG, Zephyrin L, Meoli A, Hulugalle A, Bosch J, Callegari L, et al. Reproductive Health of Women Veterans: A Systematic Review of the Literature from 2008 to 2017. Semin Reprod Med. 2018
  6. 36(6):315-22. 6.Fleischer AC, Wheeler JE, Lindsay I, Hendrix SL, Grabill S, Kravitz B, et al. An assessment of the value of ultrasonographic screening for endometrial disease in postmenopausal women without symptoms. Am J Obstet Gynecol. 2001
  7. 184(2):70-5. 7.Tsuda H, Nakamura H, Inoue T, Kawamura N, Adachi K, Bandera CA. Transvaginal ultrasonography of the endometrium in postmenopausal Japanese women. Gynecol Obstet Invest. 2005
  8. 60(4):218-23. 8.Wafa YA, Abd Alfattah AT, Korany MS. The Prognostic Value of BMI, Serum Glucose, Endometrial Echo Pattern and Uterine Artery Doppler Velocimetry as a Predictor for Endometrial Pathology in Women with Postmenopausal Bleeding (Prospective Observational Study). Open Journal of Obstetrics and Gynecology. 2019
  9. 10(1):13-24. 9.Timmermans A, Opmeer BC, Khan KS, Bachmann LM, Epstein E, Clark TJ, et al. Endometrial thickness measurement for detecting endometrial cancer in women with postmenopausal bleeding: a systematic review and metaanalysis. Obstet Gynecol. 2010
  10. 116(1):160-7. 10.Rioux JE, Devlin MC, Gelfand MM, Steinberg WM, Hepburn DS. 17βestradiol vaginal tablet versus conjugated equine estrogen vaginal cream to relieve menopausal atrophic vaginitis. Menopause. 2018
  11. 25(11):1208-13. 11.Markee JE. Menstruation in intraocular endometrial transplants in the rhesus monkey. Contrib Embryol Carnegie Inst Wash. 1940
  12. ROSENFELD CR, JACKSON GM. Induction and inhibition of uterine vasodilation by catechol estrogen in oophorectomized, nonpregnant ewes. Endocrinology. 1982
  13. 110(4):1333-9. 13.Hurtado R, Celani M, Geber S. Effect of short-term estrogen therapy on endothelial function: a double-blinded, randomized, contr