Journals / Ege Klinikleri Tıp Dergisi / 2022 / Cilt: 60 - Sayı: 1

Short and Long Term Ocular Surface Alterations in Dry Eye Patients with Sjögren's Syndrome After 0 05 Cyclosporine Use

Sjögren Sendromu Olan Kuru Göz Olgularının 0 05 Siklosporin Kullanımı Sonrası Kısa ve Uzun Dönem Oküler Yüzey Değişiklikleri

Pages
43–48
Publication Date
2022-10-11
DOI
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Purpose To evaluate the ocular surface changes after 0 05 cyclosporine treatment in patients with primary Sjögren s Syndrome Material and Methods Schirmer test, tear film break up time, fluorescein staining strip meniscometry ocular surface diseases index were evaluated in 30 patients with Sjögren s syndrome Dendritic cell density and subbasal nerve density were evaluated using in vivo confocal microscopy After topical 0 05 cyclosporine treatment the cases were reevaluated at 6 months and the findings were compared before and after treatment Twenty healthy individuals without Sjögren s syndrome and dry eye disease were determined as the control group Results: A significant improvement was observed in Schirmer test value, tear film break-up time, fluorescein staining score, strip meniscometry value and Ocular Surface Disease Index after treatment in patients with Sjögren's syndrome. (p

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Objective & Hypothesis:Purpose To evaluate the ocular surface changes after 0 05 cyclosporine treatment in patients with primary Sjögren s Syndrome Material and Methods Schirmer test, tear film break up time, fluorescein staining strip meniscometry ocular surface diseases index were evaluated in 30 patients with Sjögren s syndrome Dendritic cell density and subbasal nerve density were evaluated using in vivo confocal microscopy After topical 0 05 cyclosporine treatment the cases were reevaluated at 6 months and the findings were compared before and after treatment Twenty healthy individuals without Sjögren s syndrome and dry eye disease were determined as the control group Results: A significant improvement was observed in Schirmer test value, tear film break-up time, fluorescein staining score, strip meniscometry value and Ocular Surface Disease Index after treatment in patients with Sjögren's syndrome. (p
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Key Findings & Data:Purpose To evaluate the ocular surface changes after 0 05 cyclosporine treatment in patients with primary Sjögren s Syndrome Material and Methods Schirmer test, tear film break up time, fluorescein staining strip meniscometry ocular surface diseases index were evaluated in 30 patients with Sjögren s syndrome Dendritic cell density and subbasal nerve density were evaluated using in vivo confocal microscopy After topical 0 05 cyclosporine treatment the cases were reevaluated at 6 months and the findings were compared before and after treatment Twenty healthy individuals without Sjögren s syndrome and dry eye disease were determined as the control group Results: A significant improvement was observed in Schirmer test value, tear film break-up time, fluorescein staining score, strip meniscometry value and Ocular Surface Disease Index after treatment in patients with Sjögren's syndrome. (p
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Conclusion & Impact:Purpose To evaluate the ocular surface changes after 0 05 cyclosporine treatment in patients with primary Sjögren s Syndrome Material and Methods Schirmer test, tear film break up time, fluorescein staining strip meniscometry ocular surface diseases index were evaluated in 30 patients with Sjögren s syndrome Dendritic cell density and subbasal nerve density were evaluated using in vivo confocal microscopy After topical 0 05 cyclosporine treatment the cases were reevaluated at 6 months and the findings were compared before and after treatment Twenty healthy individuals without Sjögren s syndrome and dry eye disease were determined as the control group Results: A significant improvement was observed in Schirmer test value, tear film break-up time, fluorescein staining score, strip meniscometry value and Ocular Surface Disease Index after treatment in patients with Sjögren's syndrome. (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose To evaluate the ocular surface changes after 0 05 cyclosporine treatment in patients with primary Sjögren s Syndrome Material and Methods Schirmer test, tear film break up time, fluorescein staining strip meniscometry ocular surface diseases index were evaluated in 30 patients with Sjögren s syndrome Dendritic cell density and subbasal nerve density were evaluated using in vivo confocal microscopy After topical 0 05 cyclosporine treatment the cases were reevaluated at 6 months and the findings were compared before and after treatment Twenty healthy individuals without Sjögren s syndrome and dry eye disease were determined as the control group Results: A significant improvement was observed in Schirmer test value, tear film break-up time, fluorescein staining score, strip meniscometry value and Ocular Surface Disease Index after treatment in patients with Sjögren's syndrome. (p

Özet

Amaç Primer Sjögren sendromu olgularında 0 05 siklosporin tedavisi sonrası oküler yüzey değişikliklerini değerlendirmek Yöntem Sjögren sendromu tanılı 30 olguda Schirmer testi, gözyaşı kırılma zamanı, flöresein boyanma puanı, strip meniskometri değeri ve oküler yüzey hastalıkları indeksi değerlendirildi İn vivo konfokal mikroskopi kullanılarak dendritik hücre yoğunluğu ve subbazal sinir yoğunluğu değerlendirildi Topikal 0 05 siklosporin tedavisi sonrası, olgular 6 ayda tekrar değerlendirilerek tedavi öncesi ve sonrası bulgular kıyaslandı Primer Sjögren sendromu olmayan ve kuru göz hastalığı bulunmayan 20 sağlıklı birey kontrol grubu olarak belirlendi Bulgular Sjögren sendromlu olgularda tedavi sonrası Schirmer testi değeri, gözyaşı kırılma zamanı, flöresein boyanma puanı, strip meniskometri değeri ve Oküler Yüzey Hastalıkları İndeksi’ nde anlamlı bir iyileşme gözlendi ..( 0 001 Dendritik hücre yoğunluğu tedavi öncesi 38 3 11 3 hücre/mm 2 iken, tedavi sonrası 17 2 9 6 hücre/mm 2 ( 0 001 idi Subbazal sinir yoğunluğu ise tedavi öncesi 14 8 5 1 piksel/resim iken, tedavi sonrası 15 7 5 2 piksel/resim ( 0 05 idi Sağlıklı olgularda ise, Schirmer testi değeri 15 4 6 1 mm, gözyaşı kırılma zamanı 12 3 3 2 saniye, flöresein boyanma puanı 0 6 0 2 strip meniskometri değeri 5 8 2 mm, Oküler Yüzey Hastalıkları İndeksi 4 5 2 4 dendritik hücre yoğunluğu 8 4 2 6 hücre/mm 2 ve subbazal sinir yoğunluğu ise 25 4 3 6 piksel/resim idi Sonuç Sjögren sendromlu hastalarda 0 05 siklosporin tedavisi sonrasında oküler yüzey bulgularında anlamlı derecede iyileşme görüldü Subbazal sinir yoğunluğunda anlamlı değişiklik görülmedi Bu durumun dejenere olan sinirlerin rejenere olmamasına bağlı olduğu düşünüldü

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Cite This Article

ŞİMŞEK, C., KAYA, C., AŞIKÇI, M. K., ARALEZLİ, A. K. (2022). Short and Long Term Ocular Surface Alterations in Dry Eye Patients with Sjögren's Syndrome After 0 05 Cyclosporine Use. Ege Klinikleri Tıp Dergisi, Cilt: 60 - Sayı: 1, 43–48. https://ajindex.com/articles/495563

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