Journals / Düzce Üniversitesi Bilim ve Teknoloji Dergisi / 2017 / Cilt: 5 - Sayı: 2

Optimization of Rosmarinic Acid Extraction from Rosemary Leaves by Surface Response Methodology

Yüzey Yanıt Metodolojisi ile Biberiye Yapraklarından Rosmarinik Asit Ekstraksiyonunun Optimizasyonu

Pages
441–454
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the predicted optimal conditions, the experimental values were very close to the predicted values

📌 3 Key Takeaways

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Objective & Hypothesis:Rosmarinic acid (RA), carnosol and carnosic acid are important natural antioxidants found in rosemary (Rosmarinus officinalis).
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Key Findings & Data:RA has been reported to have some biological activities in vitro such as antiviral properties including anti-HIV-1, antibacterial, antioxidant, anti-carcinogenic, and anti-allergic activities.
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Conclusion & Impact:In the predicted optimal conditions, the experimental values were very close to the predicted values
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Rosmarinic acid (RA), carnosol and carnosic acid are important natural antioxidants found in rosemary (Rosmarinus officinalis). There are number of papers that report the biological activities of this compound, especially RA. RA has been reported to have some biological activities in vitro such as antiviral properties including anti-HIV-1, antibacterial, antioxidant, anti-carcinogenic, and anti-allergic activities. In vivo studies have shown that RA exhibit anti-allergic, anti-thrombotic, and anti-carcinogenic properties as well. Industry is increasingly interested in natural food preservatives, antimicrobial, and antioxidants due to their beneficial effects. In this work, bioactive a potent antioxidant-rosmarinic acid (RA) compound was extracted from Rosmarinus officinalis leaves. Response surface methodology (RSM) has been used to optimize the extraction conditions of antioxidants from Rosemary leaf by using ultrasonic extraction. The predicted optimal conditions for the highest RA level(6.77 %) were found at 34.37 % ethanol, 37.15 min extraction time, and 73.38°C extraction temperature. In the predicted optimal conditions, the experimental values were very close to the predicted values

Özet

Rosmarinik asit, karnozol ve karnosik asit, biberiye (Rosmarinus officinalis) 'de bulunan önemli doğal antioksidandır. Rosmarinik asit (RA), Bu bileşiklerin, özellikle de Rosmarinik asitin biyolojik aktivitelerini rapor eden çok sayıda çalışma bulunmaktadır. Rosmarinik asitin in-vitro çalışmalarda anti-HIV-1, antibakteriyel, antioksidan, anti-kanserojen ve anti-alerjik aktiviteler, antiviral özellikler gibi bazı biyolojik faaliyetleri olduğu bildirilmiştir. İn vivo çalışmalar da Rosmarinik Asit'in antialerjik, antitromboz ve antikanserojenik özellikler sergilediğini göstermiştir. Endüstri pek çok faydalı etkileri nedeniyle doğal gıda koruyucuları, antimikrobiyal ve antioksidanlar ile giderek daha fazla ilgilenmektedir. Bu çalışmada, biyolojik olarak güçlü bir antioksidan olan rosmarinik asit bileşimi, Biberiye yapraklarından ekstrakte edildi. Ultrasonik Destekli Ekstraksiyon ve Yüzey Yanıt Metodolojisi Biberiye yapraklarından antioksidanların ekstraksiyon koşullarını optimize etmek için kullanılmıştır. En yüksek Rosmarinik Asit düzeyi (% 6.77) için öngörülen optimum koşullar % 34.37 etanol konsantrasyonu, 37.15 dk ekstraksiyon zamanı ve 73.38°C ekstraksiyon sıcaklığı olarak tespit edilmiştir. Tahmin edilen optimum koşullarda, deneysel değerler tahmin edilen değerlere çok yakındı.

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Cite This Article

BULDUK, İ., GÖKCE, S. (2022). Optimization of Rosmarinic Acid Extraction from Rosemary Leaves by Surface Response Methodology. Düzce Üniversitesi Bilim ve Teknoloji Dergisi, Cilt: 5 - Sayı: 2, 441–454. https://ajindex.com/articles/494581

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