SavedAdd your journal

Journals / Düzce Üniversitesi Bilim ve Teknoloji Dergisi / 2020 / Cilt: 8 - Sayı: 1

Synthesis and Characterization of Bioactive New Benzimidazole Arene Ruthenium Organometallic Compound

Biyoaktif Yeni Benzimidazol Aren Rutenyum Organometalik Bileşiğinin Sentezi ve Karakterizasyonu

Ersin ORHAN
Enes Hakkı ULUÇAY
Pages
1020–1032
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These measurements were made by Differential thermal analysis (DTA) and Thermogravimetric analysis (TGA) techniques.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, [(η6-p-cymene)Ru(L2)Cl]CI bioactive benzimidazole arene ruthenium organometallic compound, reacting Salicylaldehyde with 2-(Aminomethyl)benzimidazole dihydrochloride, followed by the addition of the corresponding [Ru(p-cymene)chloride]2.
📊
Key Findings & Data:The bioactive benzimidazole arene ruthenium organometallic compound was characterized by standard techniques including UV-VIS, IR, ESI-MS, 1H NMR, 13C NMR spectroscopy.
💡
Conclusion & Impact:These measurements were made by Differential thermal analysis (DTA) and Thermogravimetric analysis (TGA) techniques.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Aren rutenyum · Benzimidazol · Organometalik kimya

Abstract

In this study, [(η6-p-cymene)Ru(L2)Cl]CI bioactive benzimidazole arene ruthenium organometallic compound, reacting Salicylaldehyde with 2-(Aminomethyl)benzimidazole dihydrochloride, followed by the addition of the corresponding [Ru(p-cymene)chloride]2. The bioactive benzimidazole arene ruthenium organometallic compound was characterized by standard techniques including UV-VIS, IR, ESI-MS, 1H NMR, 13C NMR spectroscopy. Thermal decomposition measurement data of arene ruthenium compound were examined. These measurements were made by Differential thermal analysis (DTA) and Thermogravimetric analysis (TGA) techniques.

Özet

Bu çalışmada [(η6-p-simen)Ru(L2)Cl]CI genel formülüne sahip olan biyoaktif benzimidazol aren rutenyum organometalik bileşiği, salisilaldehitin 2-(aminometil)benzimidazol dihidroklorür(ambm2.2HCI) bileşiği ile reaksiyona sokulmasının ardından, [Ru(p-simen)klorür]2 eklenmesi ile hazırlandı. Biyoaktif benzimidazol aren rutenyum organometalik bileşiği UV-VIS, IR, ESI-MS, 1H NMR, 13C NMR spektroskopisi teknikleriyle karakterize edildi. Bileşiğin, Diferansiyel termal analiz (DTA) ve Termogravimetrik analiz (TGA) teknikleri ile ölçümleri yapıldı, ölçüm verileri incelendi.

🔖

Cite This Article

ORHAN, E., ULUÇAY, E. H. (2022). Synthesis and Characterization of Bioactive New Benzimidazole Arene Ruthenium Organometallic Compound. Düzce Üniversitesi Bilim ve Teknoloji Dergisi, Cilt: 8 - Sayı: 1, 1020–1032. https://ajindex.com/articles/494228

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (11)

  1. M. J. Hannon, “Metal-based anticancer drugs: From a past anchored in platinum chemistry to a post-genomic future of diverse chemistry and biology,” Pure and Applied Chemistry, vol. 79, no. 12, pp. 2243–2261, 2007
  2. S. Ghosh, “Cisplatin: The first metal based anticancer drug,” Bioorganic Chemistry, vol. 88, no. 1295, pp.1-20, 2019
  3. A. A. Nazarov, C. G. Hartinger and P. J. Dyson, “Opening the lid on piano-stool complexes: An account of ruthenium(II)-arene complexes with medicinal applications,” Journal of Organometallic Chemistry, vol. 751, pp. 251-260, 2014
  4. L. A. Malley, “Cisplatin,” in Encyclopedia of Toxicology, 3rd ed., vol. 1, National Library of Medicine, Bethesda, USA, 2005, pp. 614-616
  5. E. Orhan, A. Garci and B. Therrien, “Coordination-driven self-assembly of arene ruthenium metalla-rectangles,” Inorganica Chimica Acta, vol. 461, pp. 78–83, 2017
  6. E. Orhan, A. Garci, T. Riedel, P. J. Dyson and B. Therrien, “Cytotoxicity of arene ruthenium metalla-rectangles incorporating bis-pyridyl diimide linkers,” Journal of Organometallic Chemistry, vol. 815-816, pp. 53-58, 2016
  7. A. Grozav, V. Miclaus, O. Vostinaru, S. Ghibu, C. Berce, I. Rotar, C. Mogosan, B. Therrien, F. Loghin and D. Popa, “Acute toxicity evaluation of a thiazolo arene ruthenium (II) complex 2 in rats,” Regulatory Toxicology and Pharmacology, vol. 80, pp. 233-240, 2016
  8. O. Renier, C. Deacon-Price, J. E. B. Peters, K. Nurekeyeva, C. Russon, S. Dyson, S. Ngubane, J. Baumgartner, P. J. Dyson, T. Riedel, H. Chiririwa and B. Blom, “Synthesis and in vitro (anticancer) evaluation of η6-arene ruthenium complexes bearing stannyl ligands,” Inorganics, vol. 5, no. 4, pp. 1-13, 2017
  9. W. Kandioller, C. G. Hartinger, A. A. Nazarov, J. Kasser, R. John, M. A. Jakupec, V. B. Arion, P. J. Dyson and B. K. Keppler, “Tuning the anticancer activity of maltol-derived ruthenium complexes by derivatization of the 3-hydroxy-4-pyrone moiety,” Journal of Organometallic Chemistry, vol. 694, no. 6, pp. 922-929, 2009
  10. N. Mohan, M. K. M. Subarkhan and R. Ramesh, “Synthesis, antiproliferative activity and apoptosis-promoting effects of arene ruthenium(II) complexes with N, O chelating ligands,” Journal of Organometallic Chemistry, vol. 859, pp. 124-131, 2018
  11. E. Orhan, A. Garci, T. Riedel, M. Saudani, P. J. Dyson and B. Therrien, “Cytotoxic double arene ruthenium metalla-cycles that overcome cisplatin resistance,” Journal of Organometallic Chemistry, vol. 803, pp. 39-44, 2016. [12]