Journals / Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi / 2018 / Cilt: 31 - Sayı: 3

Severe Pseudocholinesterase Deficiency and ECT: a Case Report

Şiddetli pseudokolinesteraz eksikliği ve EKT: Bir olgu sunumu

Pages
312–315
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We suggest further investigation of this topic becausescreening for PCE levels in pre-ECT assessment may reduce complications of modified ECT with anesthesia.

📌 3 Key Takeaways

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Objective & Hypothesis:Pseudocholinesterase (PCE) deficiency is an inherited condition in which recovery from anesthetic agentslike succinylcholine and mivacurium is slow and complicated by prolonged paralysis of respiratory musclesin susceptible patients.
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Key Findings & Data:We present a very rare case of a 29-year-old woman with a 15-year history ofschizophrenia with pseudocholinesterase deficiency that we encountered in our practice.
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Conclusion & Impact:We suggest further investigation of this topic becausescreening for PCE levels in pre-ECT assessment may reduce complications of modified ECT with anesthesia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Pseudocholinesterase (PCE) deficiency is an inherited condition in which recovery from anesthetic agentslike succinylcholine and mivacurium is slow and complicated by prolonged paralysis of respiratory musclesin susceptible patients. We present a very rare case of a 29-year-old woman with a 15-year history ofschizophrenia with pseudocholinesterase deficiency that we encountered in our practice. Since themeasurement of PCE levels of all patients eligible for ECT is part of our pre-ECT assessment procedure, wecould detect the deficiency before the ECT procedure. We performed modified ECT with propofol androcuronium instead of succinylcholine as usual. Sugammadex was used for speeding up the recovery.Response to treatment as measured by the Positive and Negative Symptom Scale was good and wecompleted 9 ECT sessions without complication. We suggest further investigation of this topic becausescreening for PCE levels in pre-ECT assessment may reduce complications of modified ECT with anesthesia.

Özet

Pseudokolinesteraz eksikliği, eksikliğin görüldüğü hastalarda, suksinilkolin ve mivakuryum gibi anestezi ajanlardan uyanmanın yavaş olduğu ve solunum kaslarının paralizinde uzamaya neden olabilen kalıtımsal bir durumdur. Klinik uygulamamız sırasında karşılaştığımız nadir bir olgu sunmaktayız: 15 yıllık şizofreni öyküsü bulunan ve pseudokolinesteraz eksikliği olduğunu saptadığımız 29 yaşında bir kadın hasta. PCE seviyelerinin tespiti EKT adayı bütün hastalarımızda yaptığımız rutin bir işlem olduğundan, eksikliği EKT uygulamasına başlamadan tespit edebildik. Modifiye EKT’yi suksinik kolin yerine propofol ve rokuronyum ile uyguladık. Uyanmayı hızlandırmak için sugammadex kulanıldı. Pozitif ve Negatif Belirti Ölçeği ile kaydedilen tedaviye yanıt olumluydu ve 9 EKT seansını komplikasyonsuz olarak tamamladık. EKT öncesi tetkiklerin içine pseudokolinesteraz düzeyinin konulmasının, araştırılması gereken bir konu olduğunu ileri sürmekteyiz çünkü bu yöntem anestezili modifiye EKT komplikasyonlarını azaltabilir.

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Cite This Article

YILDIZHAN, E., AYTAÇ, H. M., TOMRUK, N. B., YILDIRIM, H., CANBEK, Ö. (2022). Severe Pseudocholinesterase Deficiency and ECT: a Case Report. Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi, Cilt: 31 - Sayı: 3, 312–315. https://ajindex.com/articles/493735

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