Journals / Dahili ve Cerrahi Bilimler Yoğun Bakım Dergisi / 2017 / Cilt: 8 - Sayı: 3

Successful Treatment of Propafenone Intoxication with Intravenous Lipid Emulsion and Review of the Literature

Pages
82–85
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

For cases that do not respond to initial treatment with intravenous fluids, bicarbonate, and atropine treatment, intravenous lipid emulsion should be primarily considered among treatment choices.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Propafenone is Class Ic antiarrhythmic medication widely used for treating arrhythmias.
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Key Findings & Data:We report on the case of a 22-year-old female presenting to the Dumlupınar University Evliya Çelebi Training and Research Hospital emergency department after trying to commit suicide by ingesting 6750 mg of propafenon.
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Conclusion & Impact:For cases that do not respond to initial treatment with intravenous fluids, bicarbonate, and atropine treatment, intravenous lipid emulsion should be primarily considered among treatment choices.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Propafenone is Class Ic antiarrhythmic medication widely used for treating arrhythmias. Propafenone is commonly used for treating atrial fibrillation in patients with no structural heart disease. Intake of an excessive amount of propafenone can lead to cardiotoxic symptoms, such as hypotension, arrhythmias, and death. We report on the case of a 22-year-old female presenting to the Dumlupınar University Evliya Çelebi Training and Research Hospital emergency department after trying to commit suicide by ingesting 6750 mg of propafenon. The patient was initially treated with intravenous fluids, bicarbon-ate, and atropine. The patient’s clinical condition improved quickly and dramatically on the 15th min of intravenous lipid emulsion therapy. For cases that do not respond to initial treatment with intravenous fluids, bicarbonate, and atropine treatment, intravenous lipid emulsion should be primarily considered among treatment choices.

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Cite This Article

GÖNDEREN, K. (2022). Successful Treatment of Propafenone Intoxication with Intravenous Lipid Emulsion and Review of the Literature. Dahili ve Cerrahi Bilimler Yoğun Bakım Dergisi, Cilt: 8 - Sayı: 3, 82–85. https://ajindex.com/articles/486550

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References (13)

  1. Doepker B, Healy W, Cortez E, et al. High dose insulin and intravenous lipid emulsion therapy for cardiogenic shock induced by intentional calcium-channel blocker and beta-blocker overdose: a case series. J Emerg Med 2014
  2. [CrossRef ] 19. Wilson BJ, Cruikshank JS, Wiebe KL, et al. Intravenous lipid emulsion therapy for sustained release diltiazem poisoning: A case report. J Popul Ther Clin Pharmacol 2012
  3. Young AC, Velez LI, Kleinschmidt KC. Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose. Resuscitation 2009
  4. [CrossRef ] 17. Gosselin S, Hoegberg LC, Hoffman RS, et al. Evidence-based recommenda-tions on the use of intravenous lipid emulsion therapy in poisoning. Clin Toxicol 2016
  5. [CrossRef ] 16. Jović-Stosić J, Putić V, Zivanović D, et al. Failure of intravenous lipid emulsion in treatment of cardiotoxicity caused by mixed overdose including dihydropyri-dine calcium channel blockers. Vojnosanit Pregl 2016
  6. [CrossRef] 15. Murphy C M, Williams C, Quinn ME, et al. Pilot trial of intravenous lipid emulsion treat-ment for severe nifedipine-induced shock. J Med Toxicol 2016
  7. [CrossRef] 14. Meaney CJ, Sareh H, Hayes BD, et al. Intravenous lipid emulsion in the mana-gement of amlodipine overdose. Hosp Pharm 2013
  8. [CrossRef ] 13. St-Onge M, Anseeuw K, Cantrell FL, et al. Experts consensus recommenda-tions for the management of calcium channel blocker poisoning in adults. Crit Care Med 2017
  9. [CrossRef ] 12. Litonius ES. Treatment of acute intoxication with intravenous lipid emulsi-on-animal and human studies. Academic dissertation University of Helsin-ki,’2012. Helsinki: Unigrafia Oy. 11. Sebe A, Disel NR, Acıkalın Akpınar A, et al. Role of intravenous lipid emulsi-ons in the management of calcium channel blocker and beta-blocker over-dose: 3 years experience of a university hospital. Postgrad Med 2015
  10. [CrossRef ] 10. Zausig YA, Zink W, Graf BM. Lipophilicity of local anesthetics and success of lipid emulsion therapy. Crit Care Med 2012
  11. [CrossRef ] 9. Muller SH, Diaz JH, Kaye AD. Clinical applications of intravenous lipid emul-sion therapy. J Anesth 2015
  12. [CrossRef ] 8. Tusscher BL, Beishuizen A, Girbes ARJ, et al. Intravenous fat emulsion the-rapy for intentional propafenone intoxication. Clin Toxicol 2011
  13. [CrossRef ] 7. Dazhe C, Heard K, Foran M, et al. Intravenous lipid emulsion