Journals / Dahili ve Cerrahi Bilimler Yoğun Bakım Dergisi / 2018 / Cilt: 9 - Sayı: 3

Retrospective Evaluation of Non-neutropenic Candidemia Cases in Intensive Care Units

Yoğun Bakım Ünitelerinde Gelişen, Non-nötropenik Kandidemi Olgularının Retrospektif Olarak Değerlendirilmesi

Pages
74–77
Publication Date
2022-10-11
DOI
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The mean central venous catheter day, the mean mechanical ventilator day, and the length of hospital stay were longer in the candidemia group (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Candida species, also found in the normal microbial flora, cause infection by passing natural barriers with chronic diseases and invasive procedures.
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Key Findings & Data:Although the high risk of candidemia in neutropenic patients is known, it is also common in intensive care units (ICU), and the mortality rate is quite high.
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Conclusion & Impact:The mean central venous catheter day, the mean mechanical ventilator day, and the length of hospital stay were longer in the candidemia group (p
🔬Design:Research Article
📍Scope:2016 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Candida species, also found in the normal microbial flora, cause infection by passing natural barriers with chronic diseases and invasive procedures. Although the high risk of candidemia in neutropenic patients is known, it is also common in intensive care units (ICU), and the mortality rate is quite high. In this study, we aimed to retrospectively investigate epidemiological data, risk factors, mortality, distribution of Candida species, and accompanying bacterial infections for candidemia in non-neutropenic patients in ICU. Material and Methods: In this study, patients who were non-neutropenic and developed candidemia in the ICU of Turkey Advanced Specialty Training and Research Hospital between May 2016 and May 2017 were retrospectively evaluated. Patients who stayed (±7 days) in the same ICU, with an APACHE-II score of ±1, during the same period were included as the control group. Results: Candidemia was detected in 29 adults within 1 year. In total, 11 of the candidemia cases were females (37.9%) and 18 were males (62.1%); mean patient age was 62.0 years. The most common causative agent was Candida albicans (58.6%). In both groups, the three most common accompanying bacterial infections were Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae. Moreover, 30-day mortality was 51.7%. The mean central venous catheter day, the mean mechanical ventilator day, and the length of hospital stay were longer in the candidemia group (p

Özet

Amaç: Normal vücut florasında bulunan kandida türleri,kronik hastalıklar ve invazif işlemlerle doğal bariyerleri geçerekenfeksiyona neden olabilmektedir. Kandida ile mücadeledenötrofiller ve makrofajlar en önemli bağışıklık bileşenidir.Bu nedenle nötropenik hastalarda kandidemi riskiyüksek olmakla birlikte, yoğun bakım ünitelerinde (YBÜ)yatan hastalar nötropenik olmasalar da bu hastalarda kandidemigörülebilir ve mortalitesi oldukça yüksektir. Bu çalışmadaYBÜ’de nötropenik olmayan kandidemi olgularında,epidemiyolojik veriler, risk faktörleri, mortalite, kandida türdağılımı ve eşlik eden bakteriyel enfeksiyonların retrospektifolarak incelenmesi amaçlanmıştır.Gereç ve Yöntemler: Çalışmada Türkiye Yüksek İhtisas Eğitimve Araştırma Hastanesi, YBÜ’de Mayıs 2016 ve Mayıs2017 tarihleri arasında nötropenik olmayan, kandidemigelişen olgular retrospektif olarak değerlendirildi. Kontrolgrubu olarak aynı dönem içerisinde YBÜ’de yatan (±7gün),APACHE-II skoru ±1 olan ve kandidemi saptanmayan aynısayıda hasta çalışmaya dahil edildi.Bulgular: Bir yıllık süre içerisinde 29 erişkin hastada kandidemisaptanmıştır. Kandidemi olgularının 11’i kadın(%37,9), 18’i erkek (%62,1) olup yaş ortalaması 62,0 olaraktesbit edilmiştir. En sık saptanan etken Candida albicans(%58,6) olmuştur. Eşlik eden bakteriyel enfeksiyonlarda ilküç etken her iki grupta aynı olup Acinetobacter baumannii,Escherichia coli ve Klebsiella pneumoniae’dır. 30 günlükmortalite %51,7 bulunmuştur. Ortalama santral venöz katatergünü, ortalama mekanik ventilatör günü ve hastanedeyatış süresi kandidemi grubunda daha uzun saptanmıştır(p

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Cite This Article

TURAN, S., KAZANCI, D., TEZCAN, B., SARI, S., MUNGAN, İ., DAL, H. C. (2022). Retrospective Evaluation of Non-neutropenic Candidemia Cases in Intensive Care Units. Dahili ve Cerrahi Bilimler Yoğun Bakım Dergisi, Cilt: 9 - Sayı: 3, 74–77. https://ajindex.com/articles/486534

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