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Journals / Dahili ve Cerrahi Bilimler Yoğun Bakım Dergisi / 2018 / Cilt: 9 - Sayı: 2

An Adverse Event Associated with Antifungal Therapy: Clinic-Like Posterior Reversible Encephalopathy Syndrome

Antifungal İlaca Bağlı Gelişen Yan Etki: Posterior Reversible Ensefalopati Sendromu Benzeri Klinik?

Hatice MAVİOĞLU
Melike BATUM
Recep BOYACI
Ayşın KISABAY AK
Serpil ERBÜYÜN
Deniz HEPPEKCAN
Demet AYDIN TOK
Pages
59–62
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The primary aim of this study was to draw attention to the fact that anidulafungin may cause symptoms similar to those in PRES.

📌 3 Key Takeaways

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Objective & Hypothesis:Posterior reversible encephalopathy syndrome (PRES) is a diagnosis characterized by headache, changes in consciousness, epileptic seizures, visual symptoms (decreased visual acuity and blurred vision), vasospasm, and perfusion abnormalities in the posterior systemic vessels of the brain.
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Key Findings & Data:The most common clinical findings of PRES include headache, epileptic seizure, altered consciousness, motor deficits, and loss of vision.
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Conclusion & Impact:The primary aim of this study was to draw attention to the fact that anidulafungin may cause symptoms similar to those in PRES.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Posterior reversible encephalopathy syndrome (PRES) is a diagnosis characterized by headache, changes in consciousness, epileptic seizures, visual symptoms (decreased visual acuity and blurred vision), vasospasm, and perfusion abnormalities in the posterior systemic vessels of the brain. The most common clinical findings of PRES include headache, epileptic seizure, altered consciousness, motor deficits, and loss of vision. In the patient who presented with symptoms similar to those in PRES after the use of anidulafungin and had a history of trauma, other causes of PRES (like carotid and/or vertebral artery dissection, intra-abdominal trauma, and head trauma etc.) were excluded. In our case, visual disturbance was assessed as being secondary to central nervous system pathology. There are no similar cases in the literature that presented with clinical features of PRES and normal imaging findings. The primary aim of this study was to draw attention to the fact that anidulafungin may cause symptoms similar to those in PRES.

Özet

Posterior reversibl ensefalopati sendromu (PRES); baş ağrısı,bilinç değişiklikleri, epileptik nöbet, görsel semptomlar(görme bulanıklığı ve görme keskinliğinde azalma) ile ilişkiliolup, beynin arka sistem damarlarında görülen vazospazmve perfüzyon bozukluğu ile karakterize olan bir tanıdır.PRES’de en sık görülen klinik bulgular; baş ağrısı, nöbetler,bilinç bulanıklığı, motor defisitler ve görme kaybıdır.Anidulafungin kullanımı sonrası PRES benzeri klinik tablo(baş ağrısı, görme bulanıklığı ve epileptik nöbet) oluşturan,travma öyküsü olan olguda, PRES kliniğine yol açacak diğernedenler (karotis ve /veya vertebral arter diseksiyonu, batıniçi travması, kafa travması vb. travmalar) yapılan tetkiklerledışlandı. Olgumuzun görme bozukluğu, santral etkilenmeyesekonder olarak değerlendirildi. İlacın epileptik nöbeteneden olması da, benzer şekilde santral nöronal etki yaptığınıişaret etmektedir. PRES kliniğine yol açıp, görüntülemesinormal sınırlarda olan olguya literatürde rastlanmadı .Bu olgu anidulafungin PRES benzeri klinik tablo oluşturabileceğinedikkat çekmek amacı ile sunulmuştur.

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Cite This Article

MAVİOĞLU, H., BATUM, M., BOYACI, R., AK, A. K., ERBÜYÜN, S., HEPPEKCAN, D., TOK, D. A. (2022). An Adverse Event Associated with Antifungal Therapy: Clinic-Like Posterior Reversible Encephalopathy Syndrome. Dahili ve Cerrahi Bilimler Yoğun Bakım Dergisi, Cilt: 9 - Sayı: 2, 59–62. https://ajindex.com/articles/486522

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References (1)

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