Perinatal Outcomes Of 126 Pregnancies With Sistemic Lupus Erythematosus

Objective & Hypothesis:DOI: 10.26650/IUITFD.344912Objective: To evaluate maternal and fetal outcomes in pregnant women with systemic lupus erythematosus (SLE).

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Key Findings & Data:Materials and Methods: This retrospective clinical study included 126 consecutive cases of pregnant women with SLE and was performed in the perinatology clinic of our university hospital.

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Conclusion & Impact:Conclusion: A multidisciplinary approach to the care of pregnant women with SLE is mandatory for good maternal and fetal outcomes.

🔬Design:Research Article

📍Scope:2002 Verileri

⚙️Variables:Sistemik lupus eritematozus · perinatal · maternal

Abstract

DOI: 10.26650/IUITFD.344912Objective: To evaluate maternal and fetal outcomes in pregnant women with systemic lupus erythematosus (SLE). Materials and Methods: This retrospective clinical study included 126 consecutive cases of pregnant women with SLE and was performed in the perinatology clinic of our university hospital. We evaluated lupus pregnancies that were followed and delivered from 2002 to 2016.Results: The mean patient age was 29.1 ± 4.6 years, and the nulliparity rate was 45.2%. Disease flare-up occurred in 11.1% of patients. Lupus anticoagulants and anticardiolipin IgG and IgM antibodies were positive in 23.8%, 18.2%, and 18.2% patients, respectively. The mean gestational age at delivery was 37.2 ± 3.7, and the mean birth weight was 2813 ± 856 g. Fetal growth restriction, preterm delivery, stillbirth, and preeclampsia rates were 16.6%, 10.3%, 10.3%, and 9.5%, respectively. Conclusion: A multidisciplinary approach to the care of pregnant women with SLE is mandatory for good maternal and fetal outcomes.

Özet

DOI: 10.26650/IUITFD.344912Amaç: Sistemik lupus eritematozus (SLE) tanısı almış ve gebe olan olguların maternal ve perinatal sonuçlarının değerlendirilmesi amaçlanmıştır.Gereç ve Yöntem: Çalışmamız 2002-2016 yılları arasında üniversitemizin perinataloji kliniğinde gebelikleri takip edilmiş 126 SLE olgusunun dosya verilerinin retrospektif olarak incelenmesiyle yapıldı. Hastaların klinik karakteristikleri, obstetrik ve perinatal sonuçları değerlendirildi.Bulgular: Hastaların ortalama yaşı 29,1± 4,6 yıl ve nulliparite oranı %45,2 idi. Gebelik sırasında hastalığın alevlenmesi hastaların %11,1’ inde görüldü. Lupus antikoagulanı, antikardiyolipin IgG ve IgM antikorlarının pozitifliği sırasıyla; %23,8 , %18,2 ve %18,2 olarak saptandı. Ortalama doğum haftası 37,2±3,7, ortalama doğum kilosu 2813 ±856 gr bulundu. Fetal büyüme kısıtlılığı, preterm doğum, ölü doğum, preeklampsi görülme oranları sırasıyla; %16,6 , %10,3 , %10,3 , %9,5 olarak bulundu. Sonuç: SLE tanılı gebelik olgularının yönetiminde multidisipliner yaklaşım ile takip ve tedavinin sağlanması olumlu maternal ve fetal sonuçlar ile ilişkilidir.

Keywords

Sistemik lupus eritematozus perinatal maternal gebelik Systemic lupus erythematosus pregnancy

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Cite This Article

Özel, A., Davutoğlu, E. A., Erenel, H., Karslı, M. F., Korkmaz, S. Ö., Madazlı, R. (2018). Perinatal Outcomes Of 126 Pregnancies With Sistemic Lupus Erythematosus. İstanbul Tıp Fakültesi Dergisi, Cilt: 81 - Sayı: 2, 51–55. https://ajindex.com/articles/48446

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References (16)

D’Cruz DP, Khamashta MA, Hughes GRV. Systemic lupus erythematosus. Lancet 2007;369(9561):587–96
Smyth A, Garovic VD. Systemic lupus erythematosus and pregnancy. Minerva Urol 2009;Nefrol 61(4):457–74
Doria A, Tincani M, Lockshin MD. Challenges of lupus pregnancies. Rheumatology 2008;47(3):9–12
Brucato A, Frassi M, Franceschini F, Cimaz R, Faden D, Pisoni MP et al. Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counter immunoelectrophoresis. A prospective study of 100 women. Arthritis Rheum 2001;44(8):1832–5
Derksen RH, Bruinse HW, de Groot PG, Kater L. Pregnancy in systemic lupus erythematosus: a prospective study. Lupus 1994; 3(3):149–55
Wong CH, Chen TL, Lee CS, Lin CJ, Chen CP.nOutcome of pregnancy in patients with systemic lupus erythematosus. Taiwan J Obstet Gynecol 2006;45(2):120–3
Yan Yuen S, Krizova A, Ouimet JM, Pope JE. Pregnancy outcome in systemic lupus erythematosus (SLE) is improving: Results from a case control study and literature review. Open Rheumatol J 2008;2:89–98
Teh CL, Wong JS, Ngeh NK, Loh WL. Systemic lupus erythematosus pregnancies: a case series from a tertiary, East Malaysian hospital. Lupus 2009;18:(3):278–82
Ambrosio P, Lermann R, Cordeiro A, Borges A, Nogueira I, Serrano F.Lupus and pregnancy—15 years of experience in a tertiary center. Clin Rev Allergy Immunol 2010;38:(2-3) 77–81
Petri M, Howard D, Repke J. Frequency of lupus flare in pregnancy: the hopkins lupus pregnancy center experience.Arthritis Rheum 1991;34:(12)1538–45
Ruitz-Irastorza G, Lima F, Alves J, Khamashta MA, Simpson J,Hughes GR et al. Increased rate of lupus flare during pregnancy and the puerperium. Br J Rheumatol 1996;35:(2)133–38 12. Clowse ME, Jamison M, Myers E, James AH. A national study of the complications of lupus in pregnancy. Am J Obstet 2008; Gynecol 199(127):e1–e6
Hochberg MC. Updating the american college of rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997; 40:(9)1725
Mok CC, Wong RWS. Pregnancy in systemic lupus erythematosus. Postgrad Med J 2001;77(905):157–65
Mauragani CP, Dafni UG, Tzioufas AG, Moutsopoulos HM. Pregnancy outcome and anti-Ro/SSA in autoimmune disease. A retrospective cohort study. Br J Rheumatol 1998; 37:(7) 740–45
Georgiou PE, Politi EN, Saka V, Drosos AA. Outcome of lupus pregnancy: a controlled study. Rheumatology 2000; 39(9):1014–9
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