Journals / Çocuk Sağlığı ve Hastalıkları Dergisi / 1997 / Cilt: 40 - Sayı: 1

gamma-delta T lymphocytes by the flow cytometry in the peripheral blood of children with celiac disease

Çölyak hastalığı olan çocuklarda periferik kanda akım sitometrisi ile gamma-delta pozitif T lenfosit altkümesi

Pages
73–77
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, the percentage of peripheral yS TCR+ lymphocytes has no descriptive value in the diagnosis of celiac disease.

📌 3 Key Takeaways

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Objective & Hypothesis:Artan R, Mıhçı E, Karadoğan İ, Ündar L. (Departments of Pediatrics and Internal Medicine, Akdeniz University Faculty of Medicine, Antalya, Turkey). yS T lymphocytes by the flow cytometry in the peripheral blood of children with celiac disease.
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Key Findings & Data:Çocuk Sağlığı ve Hastalıkları Dergisi 1997; 40: 73-77. -We investigated the proportion of peripheral y8 T-cell-receptor-bearing lymphocytes (y8 TCR+), and its diagnostic value.
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Conclusion & Impact:In conclusion, the percentage of peripheral yS TCR+ lymphocytes has no descriptive value in the diagnosis of celiac disease.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Artan R, Mıhçı E, Karadoğan İ, Ündar L. (Departments of Pediatrics and Internal Medicine, Akdeniz University Faculty of Medicine, Antalya, Turkey). yS T lymphocytes by the flow cytometry in the peripheral blood of children with celiac disease. Çocuk Sağlığı ve Hastalıkları Dergisi 1997; 40: 73-77. -We investigated the proportion of peripheral y8 T-cell-receptor-bearing lymphocytes (y8 TCR+), and its diagnostic value. An increase in intraepithelial yS TCR+ lymphocytes is an important guide in the diagnosis of celiac disease. The percentage of y8 TCR+ lymphocytes were analyzed in 27 children with celiac disease verified with a control biopsy, 11 children with chronic active duodenitis and gastritis, and 16 children with neither inflammation nor gastrointestinal disease. There was no difference between the celiac group [0.4% (0.1-10%)], the group with chronic active duodenitis and gastritis [1.6% (0.1-14.2%)], and controls [0.2% (0.1-3.0%)]. In conclusion, the percentage of peripheral yS TCR+ lymphocytes has no descriptive value in the diagnosis of celiac disease.

Özet

y8 T lenfosit reseptörü taşıyan (y5 TCR+) altkümesinin periferik kandaki oranını ve bunun tanıdaki değerini araştırdık. Proksimal ince bağırsağın intraepitelyal y8 TCR+ lenfositlerinin artmış bulunması, çölyak hastalığının tanısında önemli bir yol gösterici olabilir. Çölyak hastalığı tanısı kesinleştirilmiş çocuklarda (n=27), kronik aktif duodenit ve gastrit tanısı olan çocuklarda (n=11) ve enflamatuar veya gastroenterolojik hastalığı bulunmayan çocuklarda (n=16), periferik kanda akım sitometrisi (flow cytometry) ile y5 TCR+ lenfositlerin oranı belirlendi. Çölyak grubu [%0.4 (0.1-10)] ile kronik aktif duodenit ve gastrit grubu [% 1.6 (0.1-14.2)] ve kontrol grubu [% 0.2 (0.1-1-3)] arasında anlamlı farklılık olmamakla birlikte (p

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Cite This Article

ARTAN, R., MIHÇI, E., KARADOĞAN, İ., ÜNDAR, L. (2022). gamma-delta T lymphocytes by the flow cytometry in the peripheral blood of children with celiac disease. Çocuk Sağlığı ve Hastalıkları Dergisi, Cilt: 40 - Sayı: 1, 73–77. https://ajindex.com/articles/484292