Immune response in children with steady-state sickle cell anemia

Objective & Hypothesis:This study was performed to investigate the immune system and immune responses in steady-state sickle cell anemia patients.

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Key Findings & Data:Twenty-seven patients with homozygous sickle cell anemia and 19 healthy children of hemoglobin genotype HbAA were included in the study.

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Conclusion & Impact:In addition, the percentage of total B, total T, CD4+ and CD8+ cells were measured to investigate the cellular immune system CRP (p

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

This study was performed to investigate the immune system and immune responses in steady-state sickle cell anemia patients. Twenty-seven patients with homozygous sickle cell anemia and 19 healthy children of hemoglobin genotype HbAA were included in the study. Immunglobulins, complement components C3 and C4, CRP, alpha-1 antitrypsin, ferritin, transferrin and haptoglobulin levels were measured. In addition, the percentage of total B, total T, CD4+ and CD8+ cells were measured to investigate the cellular immune system CRP (p

Özet

Orak hücreli anemili hastalarda kriz dışı asemptomatik dönemde immün sistemin değerlendirilmesi amacıyla 27 homozigot çocukta ve genotipi HbAA olan 19 sağlıklı çocukta humoral ve hücresel immün sistem parametreleri incelendi. İmmünglobülinler, kompleman sisteminden C3 ve C4, akut faz reaktanlarından CRP, alfa-1-antitripsin, ferritin, haptoglobin ve transferrin, hücresel immün sistemin total B ve T lenfositleri, CD4 ve CD8 yüzdeleri ölçülerek karşılaştırıldı. Hasta grubunda, kontrol grubuna göre akut faz reaktanlarından CRP (p

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Cite This Article

YAMAN, A., ŞAŞMAZ, İ., KILINÇ, Y., TANYELİ, A., KOCABAŞ, E., ANTMEN, B., TİKER, F. (2022). Immune response in children with steady-state sickle cell anemia. Çocuk Sağlığı ve Hastalıkları Dergisi, Cilt: 42 - Sayı: 1, 37–46. https://ajindex.com/articles/484191