Journals / Çocuk Enfeksiyon Dergisi / 2021 / Cilt: 15 - Sayı: 1

Evaluation of Clinical and Laboratory Findings of Children Who Have Hepatitis A Virus Infection

Hepatit A Virüsü Enfeksiyonu Geçiren Çocukların Klinik ve Laboratuvar Bulgularının Değerlendirilmesi

Pages
12–18
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Overall mortality rate was 0.9%.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Hepatitis A virus (HAV) infection is a common disease in the community and can cause significant morbidity and mortality in older ages.
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Key Findings & Data:Material and Methods: Clinical and laboratory findings of 105 children diagnosed with acute HAV infection between January 2017 and December 2017 in Şanlıurfa Training and Research Hospital, South-East Turkey, were examined.
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Conclusion & Impact:Overall mortality rate was 0.9%.
🔬Design:Research Article
📍Scope:2017 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Hepatitis A virus (HAV) infection is a common disease in the community and can cause significant morbidity and mortality in older ages. This study to investigate and discuss the clinical and laboratory findings, treatment and prognosis of children with acute viral hepatitis A in our hospital. Material and Methods: Clinical and laboratory findings of 105 children diagnosed with acute HAV infection between January 2017 and December 2017 in Şanlıurfa Training and Research Hospital, South-East Turkey, were examined. Results: 54.3% (n= 57) of the patients were males, and mean age was 6.7 ± 3.4 years (range: 1-17 years). 65.7% of the patients were Syrian refugees, and most of the cases were admitted in winter and autumn months. The most common symptoms were jaundice (93.3%), fatigue (76.2%), fever (67.6%), anorexia (66.6%) and abdominal pain (57.1%). Serum AST, ALT, ALP, GGT, total bilirubin and direct bilirubin levels were high in all patients. Hematologic abnormalities and acute liver failure occurred in 53.4% and 3.8% of the cases, respectively. Two patients (1.9%) had gallbladder hydrops, one patient (0.9%) had reactive arthritis and one patient (0.9%) had autoimmune hepatitis. Overall mortality rate was 0.9%. Conclusion: HAV infection is still an important public health problem in our country. The disease ranges from mild clinical course to complicated cases such as acute liver failure. Improving environmental conditions along with immunization and educating the public on hygiene are very important in disease prevention.

Özet

Giriş: Hepatit A virüs (HAV) enfeksiyonu, sık görülen, özellikle ileri yaşlarda morbidite ve mortalite nedeni olabilen önemli bir enfeksiyondur. Bu çalışmada, HAV enfeksiyonu tanısı almış çocukların klinik ve laboratuvar özelliklerinin tanımlanması amaçlandı. Gereç ve Yöntemler: Şanlıurfa Eğitim ve Araştırma Hastanesi’nde Ocak 2017 ile Aralık 2017 tarihleri akut HAV enfeksiyonu tanısı konulan 105 çocuk olgunun klinik ve laboratuvar özellikleri incelenmiştir. Bulgular: Hastaların %54.3’ü (n= 57) erkek olup yaş ortalaması 6.7 ± 3.4 yıl (sınır: 1-17 yıl) bulundu. Hastaların %65.7’si Suriyeli sığınmacılardan oluşmaktaydı ve olguların en sık kış ve sonbahar aylarında başvurduğu saptandı. En sık yakınmaların sarılık (%93.3), halsizlik (%76.2), ateş (%67.6), iştahsızlık (%66.6) ve karın ağrısı (%57.1) olduğu belirlendi. Olguların tamamında serum ALT, AST, ALP, GGT, total bilirubin ve direkt bilirubin düzeylerinde yükseklik gözlendi. Olguların %53.4’ünde hematolojik anormallikler, %3.8’sinde ise akut karaciğer yetmezliği eşlik etmişti. İki hastada (%1.9) safra kesesi hidropsu, bir hastada (%0.9) reaktif artrit ve bir hastada ise (%0.9) otoimmün hepatit gelişmişti. Genel olarak mortalite oranı %0.9 idi. Sonuç: Dünya ve ülkemizde akut HAV enfeksiyonu ciddi bir toplum sağlığı sorunu olmaya devam etmektedir. Hastalık klinik seyri hafif formdan akut karaciğer yetmezliği gibi komplike vakalara kadar değişebilmektedir. Hastalıktan korunmada bağışıklama ile birlikte çevre koşullarının iyileştirilmesi ve hijyen konusunda halkın eğitilmesi çok önemlidir

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Cite This Article

DEVECİ, U., SALI, E. (2022). Evaluation of Clinical and Laboratory Findings of Children Who Have Hepatitis A Virus Infection. Çocuk Enfeksiyon Dergisi, Cilt: 15 - Sayı: 1, 12–18. https://ajindex.com/articles/484049

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