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Journals / İstanbul Tıp Fakültesi Dergisi / 2020 / Cilt: 83 - Sayı: 3

THE MEASUREMENT OF THE CHOROIDAL THICKNESS DURING ORAL GLUCOSE TOLERANCE TESTS IN PREDIABETIC SUBJECTS: A SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY STUDY

PREDİYABETİK HASTALARDA YAPILAN ORAL GLİKOZ TOLERANS TESTİ ESNASINDA KOROİD KALINLIĞININ ÖLÇÜLMESİ: SPEKTRAL DOMAİN OPTİK KOHERENS TOMOGRAFİ ÇALIŞMASI

Eylem ÇAĞILTAY
Muhammed ALTINIŞIK
Sjaak POUWELS
Nur DEMİR
Fahrettin AKAY
Pages
184–192
Publication Date
2020-06-29
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Fasting Plasma Glucose (FPG) levels of the patients with only isolated Impaired Fasting Glucose (IGT) patients are higher (all p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of this study is to investigate how acute hyperglycaemic changes affect the choroid in patients with prediabetes.
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Key Findings & Data:Material and Method: Each subject underwent a 75 g oral glucose tolerance test (OGTT) after overnight fasting.
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Conclusion & Impact:Results: Fasting Plasma Glucose (FPG) levels of the patients with only isolated Impaired Fasting Glucose (IGT) patients are higher (all p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Koroid kalınlığı · oral glukoz tolerans testi · spektral domain optik koherens tomografi

Abstract

Objective: The aim of this study is to investigate how acute hyperglycaemic changes affect the choroid in patients with prediabetes. Material and Method: Each subject underwent a 75 g oral glucose tolerance test (OGTT) after overnight fasting. The measurement of choroidal thickness (ChT) was done with new generation spectral domain optical coherence tomography (SD-OCT). Results: Fasting Plasma Glucose (FPG) levels of the patients with only isolated Impaired Fasting Glucose (IGT) patients are higher (all p

Özet

Amaç: Akut hiperglisemik değişikliklerin prediyabetli hastalarda koroidi nasıl etkilediğini araştırmak. Gereç ve Yöntem: Hastalara en az 8 saat kalori alınmaması sonrası 75 g oral glukoz tolerans testi (OGTT) uygulandı. Koroid kalınlığı (ChT), yeni nesil spektral domain optik koherens tomografi (SD-OCT) ile ölçüldü. Bulgular: Koroid kalınlığındaki değişiklikler gruplar arasında farklılık göstermiştir. Prediyabetli bireylerde, foveaya 500 µm mesafedeki subfoveal, nazal ve temporal lokasyonların yanı sıra ortalama ChT’de geçici bir artış gözlenmiştir. OGTT’nin ilk saatinde; prediyabetik grupta subfoveal koroid kalınlığı farkı 1,52±4,11 µm (aralık, -11,00/24,00 µm) iken, kontrol grubunda subfoveal ChT farkı -0,22±1,74 µm (aralık -2,00/8,00 µm) olarak ölçüldü. Sonuç: Akut hiperglisemik değişikliklerin anlık ölçümlerle saptanması, hastalığın oküler yapılar üzerindeki etkisini daha iyi anlamamıza yardımcı olabilir.

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Cite This Article

ÇAĞILTAY, E., ALTINIŞIK, M., POUWELS, S., DEMİR, N., AKAY, F. (2020). THE MEASUREMENT OF THE CHOROIDAL THICKNESS DURING ORAL GLUCOSE TOLERANCE TESTS IN PREDIABETIC SUBJECTS: A SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY STUDY. İstanbul Tıp Fakültesi Dergisi, Cilt: 83 - Sayı: 3, 184–192. https://ajindex.com/articles/48365

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References (13)

  1. Smith-Palmer J, Brandle M, Trevisan R, Orsini FM, Liabat S, Valentine W. Assessment of the association between glycemic variability and diabetes related complications in type 1 and type 2 diabetes. Diabetes Res Clin Pract 2014
  2. 27384. [CrossRef] 2. Abdul-Ghani M, Defronzo RA, Jayyousi A. Prediabetes and risk of diabetes and associated complications: Impaired fasting glucose versus impaired glucose tolerance: does it matter? Curr Opin Clin Nutr Metab Care 2016
  3. [CrossRef] 3. World Health Organization. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation. Geneva: World Health Organization, 2006:1-50. 4. Fujiwara T, Imamura Y, Margolis R, et al. Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes. Am J Ophthalmol 2009
  4. [CrossRef] 5. Zeng J, Li J, Liu R, et al. ChT in both eyes of patients with unilateral idiopathic macular hole. Ophthalmology 2012
  5. [CrossRef] 6. Dhoot DS, Huo S, Yuan A, et al. Evaluation of ChT in retinitis pigmentosa using enhanced depth imaging optical coherence tomography. Br J Ophthalmol 2013
  6. [CrossRef] 7. Kim SW, Oh J, Kwon SS, et al. Comparison of ChT among patients with healthy eyes, early age-related maculopathy, neovascular age-related macular degeneration, central serous chorioretinopathy, and polypoidal choroidal vasculopathy. Retina 2011
  7. [CrossRef] 8. Nagaoka T, Kitaya N, Sugawara R, et al. Alteration of choroidal circulation in the foveal region in patients with type 2 diabetes. Br J Ophthalmol 2004
  8. [CrossRef] 191 Choroidal thickness changes after OGTT İstanbul Tıp Fakültesi Dergisi • J Ist Faculty Med 2020
  9. 83(3):184-92 9. Chen Q, Fan T, Wu Y, et al. Characteristics of Retinal Structural and Microvascular Alterations in Early Type 2 Diabetic Patients. Invest Opthal Vis Sci 2018
  10. [CrossRef] 10. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol Metab 1979
  11. 237(3):214-23. [CrossRef] 11. Cersosimo E, Solis-Herrera C, Trautmann ME, Malloy J, Triplitt CL. Assessment of pancreatic beta-cell function: review of methods and clinical applications. Curr Diabetes Rev 2014
  12. [CrossRef] 12. Klefter ON, Vilsboll T, Knop FK, et al. Retinal vascular and structural dynamics during acute hyperglycaemia. Acta Ophthalmol 2015
  13. [CrossRef] 13. Anderson EA, Hoffman RP, Balon TW, Sinke