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Journals / Journal of Microbiology and Infectious Diseases / 2012 / Cilt: 2 - Sayı: 04

Role of Gallstones in Typhoid Carriage in Egyptian Patients

Marwa Abdelazim Mansour
Tarik Zaher
Amany Ibrahim
Amira Ahmed
Islam Ibrahim
Ashraf Goda
Nehad Ahmed
Pages
142–149
Publication Date
2012-12-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Chronic calcular cholecystitis patients are more prone to typhoid carriage due to biofilm formation of S. typhi on the surface of gallstones.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Salmonella typhi forms biofilm on the surface of gallstones promoting colonization and carrier state.
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Key Findings & Data:Materials and methods: The study group included 257 patients with chronic calcular cholecystitis.
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Conclusion & Impact:Conclusion: Chronic calcular cholecystitis patients are more prone to typhoid carriage due to biofilm formation of S. typhi on the surface of gallstones.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Gallstones · thyphoid carriage

Abstract

Objectives: Salmonella typhi forms biofilm on the surface of gallstones promoting colonization and carrier state. The aims are to detect its frequency in chronic calcular cholecystitis patients, to find out their antibiotic resistance pattern, and also to examine biofilm on the surface of gallstones and detect its correlation to antibiotic susceptibility pattern. Materials and methods: The study group included 257 patients with chronic calcular cholecystitis. S. typhi was isolated from gall bladder specimens. Antibiotics susceptibility tests of the isolates were done. Biofilm on surface of gallstones were visualized using scanning electron microscopy. Virulence (Vi) antibodies against S. typhi were studied in sera of 257 healthy controls. Results: 10.9% of patients were chronic typhoid carriers compared to only 3.5% of the controls (OR= 3.37, p=0.002). Multidrug resistance was detected in 35.7% of isolates. S. typhi biofilms on the surface of the 21/28 (75%) gallstones were detected. Ninety percent of the strains that produced maximum amount of biofilm were multidrug-resistant. Conclusion: Chronic calcular cholecystitis patients are more prone to typhoid carriage due to biofilm formation of S. typhi on the surface of gallstones.

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Cite This Article

Mansour, M. A., Zaher, T., Ibrahim, A., Ahmed, A., Ibrahim, I., Goda, A., Ahmed, N. (2012). Role of Gallstones in Typhoid Carriage in Egyptian Patients. Journal of Microbiology and Infectious Diseases, Cilt: 2 - Sayı: 04, 142–149. https://ajindex.com/articles/48327

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