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Journals / Çağdaş Cerrahi Dergisi / 2002 / Cilt: 16 - Sayı: 1

Effect of hyaluronic acid-carboxymehylcellulose (HA-CMC) antiadhesion barrier on ischemic colonic anastomosis: An experimental study

Hyaluronik asit-karboksimetil sellüloz (HA-KMS) antiadeziv bariyerin, iskemik kolon anastomozuna etkileri

Süphan ERTÜRK
Hüriye BALCI
Serdar YÜCEYAR
Haluk SANER
Muhyittin TEMİZ
Ali CENGİZ
Baki EKÇİ
Pages
3–8
Publication Date
2022-10-10
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

HP level was significantly higher in HA-CMS group than ischémie one (p

📌 3 Key Takeaways

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Objective & Hypothesis:Effect of Hyaluronic Acid-Carboxymethylcellulose (HA-CMC) Antiadhesion Barrier on Ischémie Colonie Anastomosis: An Experimental Study Hyaluronic acid-carboxymethylcellulose (HA-CMC) have been shown to be effective agent in decreasing formation of postoperative adhesions.
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Key Findings & Data:In all groups, rats were saerified 7 days later.
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Conclusion & Impact:HP level was significantly higher in HA-CMS group than ischémie one (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Effect of Hyaluronic Acid-Carboxymethylcellulose (HA-CMC) Antiadhesion Barrier on Ischémie Colonie Anastomosis: An Experimental Study Hyaluronic acid-carboxymethylcellulose (HA-CMC) have been shown to be effective agent in decreasing formation of postoperative adhesions. There are several, experimental and clinical studies with different results regarding the effects of HA-CMS on bowel, anastomosis. However, we failed to encounter any study in current literature concerning the effects of HACMS on ischémie bowel anastomosis. Thirty WistarAlbino rats were divided into three groups. In group A (control), wellpeifused distal colonie segment was transected and free ends were anastomosed. In group B, first ischémie colonie segment was prepared, then divided and anastomosed. In group C, after completion of ischémie colonie anastomosis, HA-CMS film was wrapped around anastomosis. In all groups, rats were saerified 7 days later. Anastomotic healing was assessed by measurement of bursting pressure and hydroxyproline (HP) content of anastomotic tissue. The results were evaluated by Oneway ANOVA and Post Hoc Tests. HP level was significantly higher in HA-CMS group than ischémie one (p

Özet

Antiadeziv bir ajan olan HA-KMS'un barsak anastomozlan üzerine etkileri kapsamlı olarak araştırılmıştır. Ancak HA-KMS'un İskemik barsak anastomozları üzerine etkileri konusunda literatürde yeterli veri yoktur. Otuz adet W istarAlbino rat, her biri 10 denek içeren üç gruba ayrıldı. Grup A'da (kontrol), normal olarak beslenen distal kolon segment! ikiye bölündükten sonra serbest uçlar anastomoze edildi. Grup B'de önce İskemik distal kolon segmenti hazırlandı. Daha sonra, İskemik kolon ikiye bölünüp serbest uçlar tekrar anastomoze edildi. Grup C'de ise, hazırlanan İskemik kolon segmentinin anastonıozu tamamlandıktan sonra, anastomoz etrafına HA-KMS tabakası sarıldı. Tüm gruplarda denekler postoperatif7.ci gün sakrifiye edildi. Anastomoz iyileşmesi, patlama basıncı ve anastomotik dokuda hidroksiprolin (HP) tayini yapılarak değerlendirildi. Sonuçlar, Oneway ANOVA ve Post Hoc testleri kullanılarak değerlendirildi. HA-KMS grubunda HP düzeyi İskemik gruba göre anlamlı derecede yüksekti (p

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Cite This Article

ERTÜRK, S., BALCI, H., YÜCEYAR, S., SANER, H., TEMİZ, M., CENGİZ, A., EKÇİ, B. (2022). Effect of hyaluronic acid-carboxymehylcellulose (HA-CMC) antiadhesion barrier on ischemic colonic anastomosis: An experimental study. Çağdaş Cerrahi Dergisi, Cilt: 16 - Sayı: 1, 3–8. https://ajindex.com/articles/482255

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