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Journals / Cyprus Journal of Medical Sciences / 2021 / Cilt: 6 - Sayı: 2

An Uncommon Cause of Hypernatremia in Very Low Birth Weight Premature Infants: Idiopathic Central Diabetes Insipidus

Selma AKTAŞ
Ebru KAZANCI
Ayşe KORKMAZ
Serap SEMİZ
Pages
177–179
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Persistent hypernatremia despite increased fluid intake with polyuria, hyposthenuria, low urine output, and high plasma osmolality is the key point for the diagnosis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Central diabetes insipidus (CDI) is a water homeostasis disorder characterized by an inability to concentrate urine because of insufficient production of antidiuretic hormone.
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Key Findings & Data:We report two cases, who presented persistent hypernatremia with polyuria despite increased fluid supply and low sodium intake.
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Conclusion & Impact:Persistent hypernatremia despite increased fluid intake with polyuria, hyposthenuria, low urine output, and high plasma osmolality is the key point for the diagnosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Central diabetes insipidus (CDI) is a water homeostasis disorder characterized by an inability to concentrate urine because of insufficient production of antidiuretic hormone. Dehydration with hypernatremia can occur during the neonatal period in preterm neonates in association with insensible water loss, high urine output, and reduced sodium excretion. A high index of suspicion is required to diagnose CDI in preterm neonates. We report two cases, who presented persistent hypernatremia with polyuria despite increased fluid supply and low sodium intake. CDI diagnosis was confirmed by the therapeutic test with oral vasopressin analog. Investigations were all normal; CDI was considered idiopathic. Persistent hypernatremia despite increased fluid intake with polyuria, hyposthenuria, low urine output, and high plasma osmolality is the key point for the diagnosis.

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Cite This Article

AKTAŞ, S., KAZANCI, E., KORKMAZ, A., SEMİZ, S. (2022). An Uncommon Cause of Hypernatremia in Very Low Birth Weight Premature Infants: Idiopathic Central Diabetes Insipidus. Cyprus Journal of Medical Sciences, Cilt: 6 - Sayı: 2, 177–179. https://ajindex.com/articles/482179

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