Journals / Cerrahpaşa Tıp Dergisi / 2003 / Cilt: 34 - Sayı: 2

The prognostic value of neuron specific enolase after acute ischemic stroke

Akut iskemik strokta serum nöron-spesifik enolaz'ın prognostik değeri

Pages
81–85
Publication Date
2022-10-10
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results and Conclusion.- There was a statistically significant difference in serum NSE values at 48th hours and fifth days of whole patient group (22,51±7.05 ng/ml, 13,1±4,76 ng/ml, respectively) compared to those of control group (8.54±2,58 ng/ml), ( p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background.- The aim of the study was to see whether the serum neuron specific enolase (NSE) levels, as a noninvasive technique could be utilized to determine the morbidity at early stage after acute ischemic stroke.
📊
Key Findings & Data:Design.- In the present study, 40 patients with acute ischemic stroke and 20 ages and gender matched volunteer were investigated.
💡
Conclusion & Impact:Results and Conclusion.- There was a statistically significant difference in serum NSE values at 48th hours and fifth days of whole patient group (22,51±7.05 ng/ml, 13,1±4,76 ng/ml, respectively) compared to those of control group (8.54±2,58 ng/ml), ( p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background.- The aim of the study was to see whether the serum neuron specific enolase (NSE) levels, as a noninvasive technique could be utilized to determine the morbidity at early stage after acute ischemic stroke. Design.- In the present study, 40 patients with acute ischemic stroke and 20 ages and gender matched volunteer were investigated. Serum NSE levels at 48th hours, fifth days, and tenth days were analyzed and simultaneous clinical status according to Scandinavian stroke scale was examined and infarct volumes at 48th hours were measured. Results and Conclusion.- There was a statistically significant difference in serum NSE values at 48th hours and fifth days of whole patient group (22,51±7.05 ng/ml, 13,1±4,76 ng/ml, respectively) compared to those of control group (8.54±2,58 ng/ml), ( p

Özet

Bu çalışmanın amacı, akut iskemik strok sonrası morbiditenin erken dönemde belirlenmesinde serum Nöron Spesifik Enolaz (NSE) düzeyinin noninvazif bir yöntem olarak kulanı-lıp kullanılamayacağını araştırmaktır. Bu çalışmaya akut iskemik stroklu 40 hasta ve yaş ve cinsiyet özellikleri uyumlu 20 gönüllü alınmıştır. Çalışma grubunun strok sonrası 48. saat, 5. ve 10. günlerdeki serum NSE düzeyleri ile eş zamanlı Scandinavian Strok Skalası'na göre klinik durumları ve 48. saatteki infarkt volümleri belirlendi. Tüm hastaların 48. saatteki ve beşinci gündeki serum NSE değerleri ile (sırasıyla; 22,51$pm$7,05 ng/ml, 13,1±4,76 ng/ml) kontrol grubunun serum NSE değerleri (8,54±2,58 ng/ml) arasında istatistiksel olarak anlamlı fark bulun- du (sırasıyla p

🔖

Cite This Article

MÜNGEN, B., BERİLGEN, M. S., DOLU, Y., BULUT, S. (2022). The prognostic value of neuron specific enolase after acute ischemic stroke. Cerrahpaşa Tıp Dergisi, Cilt: 34 - Sayı: 2, 81–85. https://ajindex.com/articles/473491

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (1)

  1. Day INM, Thopson RJ. Levels of immunoreactive aldolase C, creatine kinase-BB, neuronal and nonneuronal enolase and 14-3-2 protein in circulating human blood cells. Clin Chem Acta 1984; 136: 219-228. 2.Marangos PJ, Champbell IC, Godvin FK. Structural and functional properties of neuron specific protein (NSP) from rat, cat and human brain. J Neurcochem 1977; 28: 1097-1107. 3.Cunningham RT, Watt M, Winder J. Serum neurone- specific enolase as an indicator of stroke volume. Eur J Clin Invest 1996; 26: 298-303. 4.Cunningham RT, Young IS, Winder J. Serum neurone specific enolase (NSE) levels as an indicator of neuronal damage in patients with cerebral infarction. Eur J Clin Invest 1991; 21: 497-500. 5.Martens P, Raabe A, Johnsson P. Serum S-100 and neuron-specific enolase for prediction of regaining consciousness after global cerebral ischemia. Stroke 1998;29:2363-2366. 6.Missler U, Wiesmann M, Friedrich C, Kaps M. S-100 Protein and neuron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke. Stroke 1997; 28: 1956-1960. 7.Stevens H, Jakobs C, de Jager AE, Cunningham RT, Korf J. Neurone-specific enolase and N-acetyl-aspartate as potential peripheral markers of ischemic stroke. Eur J Clin Invest 1999; 29: 16-11. 8.Wunderlich MD, Ebert AD, Kratz T, Goertler M, Jost S, Herrmann M. Early neurobehavioral outcome after stroke is related to release of neurobiochemical markers of brain damage. Stroke 1999; 30: 1190-1195. 9.Waltraud S, Harald K, Fritz S, Wilhelm B, Michael Holzer. Time course of serum neuron-specific enolase apredictor of neurological outcome in patients resuscitated from cardiac arrest. Stroke 1999; 30: 1598- 1603. 10.Savory J,Brody JP. Measurements and diagnostic values of.CS'F enzymes. Ann Clin Lab Sci 1979; 1: 69-79. 11. Williams LD, Marks V. Chemistry of the cerebrospinal fluid in health and disease biochemistry in clinical practice. London: William Heinman Medical Books Limited. 1983: 445-465. 12.Steinberg R, Gueniau C, Scarna H, Keller A, Worcel M, Pujol JF. Experimental brain ischemia: Neuron-specific enolase level in cerebrospinal fluid as an index of neuronal damage. J Neurochem 1984; 43: 19-24. 13.Cunnigham RT, Morrow JI, Johnston CF, Buchanan KD. Neuron-specific enolase concentrations in patients with neurological disorders. Clin Chim Acta 1994; 230: 117- 124. 14.De Giorgio CM, Correale JD, Gott PS. Serum neuron- specific enolase in human status epilepticus. Neurology 1995; 45: 11