Journals / Avrupa Bilim ve Teknoloji Dergisi / 2021 / Sayı: 28

MicroRNAs in molecular technology to address global diseases bench to bedside research

Küresel hastalık tezgahından başucu araştırmasına yönelik moleküler teknolojideki mikroRNA'lar

Pages
1492–1500
Publication Date
2021-11-30
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It will facilitate scientist in future to judge the perspective of microRNA applications in multiple clinical scenarios by simple bioinformatics analysis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:MicroRNAs a category of noncoding RNA dysregulations are involved in numerous pathological conditions including cancer, diabetes, heart diseases, immunological disorders, neurological diseases and many metabolic diseases.
📊
Key Findings & Data:Advancement in the knowledge of microRNA applications led to the diagnosis of some early markers of diseases.
💡
Conclusion & Impact:It will facilitate scientist in future to judge the perspective of microRNA applications in multiple clinical scenarios by simple bioinformatics analysis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:mikroRNA · teşhis belirteçleri · uygulamalar.

Abstract

MicroRNAs a category of noncoding RNA dysregulations are involved in numerous pathological conditions including cancer, diabetes, heart diseases, immunological disorders, neurological diseases and many metabolic diseases. Advancement in the knowledge of microRNA applications led to the diagnosis of some early markers of diseases. Currently innovative molecular biotechnology is holding promising future in the field of application of microRNA silencers and inhibitors, replacers and over expressers for tackling life threatening diseases. RNA seq libraries of mega patients groups in the field of cancer include the expression profile of multiple microRNAs but there is need of time to develop such libraries of miRNAs in other diseases too. It will facilitate scientist in future to judge the perspective of microRNA applications in multiple clinical scenarios by simple bioinformatics analysis.

Özet

MikroRNA'lar, kodlamayan RNA düzensizliklerinin bir kategorisi, kanser, diyabet, kalp hastalıkları, immünolojik bozukluklar, nörolojik hastalıklar ve birçok metabolik hastalık dahil olmak üzere çok sayıda patolojik durumda yer alır. MikroRNA uygulamaları bilgisindeki ilerleme, bazı erken hastalık belirteçlerinin teşhisine yol açtı. Halihazırda yenilikçi moleküler biyoteknoloji, yaşamı tehdit eden hastalıklarla mücadele için mikroRNA susturucuları ve inhibitörleri, ikame ediciler ve aşırı ifade edicilerin uygulanması alanında gelecek vaat ediyor. Kanser alanındaki mega hasta gruplarının RNA dizi kütüphaneleri, çoklu mikroRNA'ların ekspresyon profilini içerir, ancak diğer hastalıklarda da bu tür mikroRNA kütüphanelerini geliştirmek için zamana ihtiyaç vardır. Gelecekte bilim adamlarının basit biyoinformatik analizi ile çoklu klinik senaryolarda mikroRNA uygulamalarının perspektifini yargılamasını kolaylaştıracaktır.

🔖

Cite This Article

AKRAM, N., SHAHZOR, Z., MUSHTAQ, I., ISHTİAQ, A., HUSSAİN, K., MURTAZA, I. (2021). MicroRNAs in molecular technology to address global diseases bench to bedside research. Avrupa Bilim ve Teknoloji Dergisi, Sayı: 28, 1492–1500. https://ajindex.com/articles/471070

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (8)

  1. Mushtaq I, Ishtiaq A, Ali T, Jan MI, Murtaza I. An Overview of Non-coding RNAs and Cardiovascular System. J Non-coding RNAs in Cardiovascular Diseases 2020:3-45.
  2. Ali T, Mushtaq I, Maryam S, Farhan A, Saba K, Jan MI, et al. Interplay of N acetyl cysteine and melatonin in regulating oxidative stress-induced cardiac hypertrophic factors and microRNAs. J Archives of biochemistry biophysics. 2019;661:56-65.
  3. Çakmak HA, Demir M. MicroRNA and cardiovascular diseases. J Balkan medical journal. 2020;37(2):60. Di Z, Di M, Fu W, Tang Q, Liu Y, Lei P, et al. Integrated analysis identifies a nine-microRNA signature biomarker for diagnosis and prognosis in colorectal cancer. J Frontiers in genetics 2020;11:192. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. J CA: a cancer journal for clinicians 2021;71(3):209-49.
  4. Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, et al. Global burden of cardiovascular diseases and risk factors, 1990–2019: update from the GBD 2019 study. J Journal of the American College of Cardiology 2020;76(25):2982-3021.
  5. Jose J, Kumar R, Harilal S, Mathew GE, Prabhu A, Uddin MS, et al. Magnetic nanoparticles for hyperthermia in cancer treatment: an emerging tool. J Environmental Science Pollution Research. 2020;27(16):19214-25.
  6. Oldfield CJ, Duhamel TA, Dhalla NS. Mechanisms for the transition from physiological to pathological cardiac hypertrophy. J Canadian journal of physiology pharmacology 2020;98(2):74-84.
  7. Zheng H, Zhang G, Zhang L, Wang Q, Li H, Han Y, et al. Comprehensive review of web servers and bioinformatics tools for cancer prognosis analysis. J Frontiers in oncology 2020;10:68. Das S, Shah R, Dimmeler S, Freedman JE, Holley C, Lee J-M, et al. Noncoding RNAs in cardiovascular disease: current knowledge, tools and technologies for investigation, and future directions: a scientific statement from the american heart association. J Circulation: Genomic Precision Medicine 2020;13(4):e000062. Nam S, Kim B, Shin S, Lee S. miRGator: an integrated system for functional annotation of microRNAs. Nucleic acids research. 2007;36(suppl_1):D159-D64. Lu T-P, Lee C-Y, Tsai M-H, Chiu Y-C, Hsiao CK, Lai L-C, et al. miRSystem: an integrated system for characterizing enriched functions and pathways of microRNA targets. 2012.
  8. Liu H, Yue D, Chen Y, Gao S-J, Huang Y. Improving performance of mammalia