Journals / Bozok Tıp Dergisi / 2014 / Cilt: 4 - Sayı: 2

Radionuclide Lymphoscintigraphy in the Evaluation of Lymphedema

LENFÖDEMİN DEĞERLENDİRİLMESİNDE RADYONÜKLİD LENFOSİNTİGRAFİ

Pages
45–52
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

So, lymphoscintigraphy is widely considered to be the main investigation to establish the diagnosis of lymphedema and visualize peripheral lymphatics.

📌 3 Key Takeaways

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Objective & Hypothesis:ABSTRACT Lymphedema is a chronic debilitating progressive disease characterized with edema, that results from impaired lymphatic transport caused by injury to the lymphatics, seconder or congenital ab- normality and is frequently misdiagnosed.
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Key Findings & Data:If a large molecule such as a protein or colloid with a radioactive label e.g., Tc-99m is injected into the in- terstitial space, its transport through the initial lymphatics, the collectors and region lymph nodes, can be followed using the gamma camera to detect the radioactivity which provides a picture of lymphatic function and pathways.
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Conclusion & Impact:So, lymphoscintigraphy is widely considered to be the main investigation to establish the diagnosis of lymphedema and visualize peripheral lymphatics.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

ABSTRACT Lymphedema is a chronic debilitating progressive disease characterized with edema, that results from impaired lymphatic transport caused by injury to the lymphatics, seconder or congenital ab- normality and is frequently misdiagnosed. It consists of excess protein-rich interstitial fluid within the skin and subcutaneous tissue resulting from lymphatic dysfunction. Besides clinical diagnosis, lymphatic flow and sites of lymph drainage can readily be evaluated with lymphoscintigraphy. Lymphatic imaging can play a pivotal role in defining the etiology of extremity swelling and in predicting the success of common therapies. Lymphoscintigraphy relies on one of the essential functions of the lymphatic system that is to transport large molecules from the interstitial space back to the vascular compartment. If a large molecule such as a protein or colloid with a radioactive label e.g., Tc-99m is injected into the in- terstitial space, its transport through the initial lymphatics, the collectors and region lymph nodes, can be followed using the gamma camera to detect the radioactivity which provides a picture of lymphatic function and pathways. So, lymphoscintigraphy is widely considered to be the main investigation to establish the diagnosis of lymphedema and visualize peripheral lymphatics.

Özet

ÖZET Lenfödem, lenf sıvısını taşıyan lenf kanalları ile lenf düğümlerinin doğuştan ya da sonradan hasa- ra uğramasına bağlı olarak lenfatik transportta meydana gelen yetmezlik sonucu gelişen ödemle karakterize, kronik, ilerleyici, sıklıkla geç tanı alan bir hastalıktır. Lenfatik yetmezlik sonucu cilt ve ciltaltı dokuda proteinden zengin sıvının aşırı birikimi mevcuttur. Klinik tanı dışında lenfatik akım ve drenaj yerleri lenfosintigrafi ile değerlendirilebilir. Lenfatik görüntüleme, ekstremitede meydana gelen şişliğin etyolojisinin belirlenmesinde ve tedavi başarısını öngörmede önemli rol oynayabilir. Lenfosintigrafi, lenfatik sistemin temel fonksiyonlarından biri olan, büyük moleküllerin interstisyel mesafeden vasküler kompartmana geri taşınması esasına dayanır. Tc-99m ile bağlı protein veya kolloid gibi radyoaktif bir madde interstisyel mesafeye enjekte edildiğinde, bu madde ilk olarak lenfatik kanallara, sonra bölgesel lenf nodlarına geçer ve gama kamera ile görüntüleme yapılarak lenfatik yollar ve fonksiyonun değerlendirmesi sağlanabilir. Bu nedenle lenfosintigrafinin, lenföde- min tanısında ve lenfatik sistemin görüntülenmesinde temel yöntem olduğu düşünülmektedir.

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Cite This Article

KARAÇAVUŞ, S., TUTUŞ, A., KULA, M. (2022). Radionuclide Lymphoscintigraphy in the Evaluation of Lymphedema. Bozok Tıp Dergisi, Cilt: 4 - Sayı: 2, 45–52. https://ajindex.com/articles/468952

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References (16)

  1. Szuba A, Rockson SG. Lymphedema: anatomy, physiology and pathogenesis. Vasc Med. 1997;2(4):321–6
  2. Campisi C. Global incidence of tropical and non-tropical lymphoedemas. Int Angiol. 1999;18(1):3–5
  3. Szuba A, Shin WS, Strauss HW, Rockson S. The third circulation: radionuclide lymphoscintigraphy in the evaluation of lymphedema. J Nucl Med. 2003;44(1):43-57
  4. Rijke AM, Croft BY, Johnson RA, de Jongste AB, Camps JA. Lymphoscintigraphy and lymphedema of the lower extremities. J Nucl Med. 1990;31(6):990–8
  5. Olszewski WL. Lymphatics, lymph and lymphoid cells: an integrated immune system. Eur Surg Res. 1986; 18 (1):264- 70
  6. Brautigam P, Foldi E, Schaiper I, Krause T, Vanscheidt W, Moser E. Analysis of lymphatic drainage in various forms of leg edema using two compartment lymphoscintigraphy. Lymphology. 1998;31(2):43–55
  7. Irrthum A, Karkkainen MJ, Devriendt K, Alitalo K, Vikkula M. Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase. Am J Hum Genet. 2000;67(2):295–301
  8. Oremus M, Dayes I, Walker K, Raina P. Systematic review: conservative treatments for secondary lymphedema. BMC Cancer. 2012;4(12):6. doi:10.1186/1471-2407-12-6
  9. Casley-Smith JR. Alterations of untreated lymphedema and its grades over time. Lymphology. 1995;28(4):174–85
  10. Lu Q, Delproposto Z, Hu A, Tran C, Liu N, Li Y, et al. MR lymphography of lymphatic vessels in lower extremity with gynecologic oncology-related lymphedema. PLoS One. 2012;7(11):e50319. doi: 10.1371/ 0050319
  11. Walker LA. Localisation of radioactive colloids in lymph nodes. J Lab Clin Med. 1950;36 (3):440-9
  12. Kazem I, Antoniades J, Brady LW, Faust DS, Croll MN, Lightfoot D. Clinical evaluation of lymph node scanning utilizing colloidal gold 198. Radiology. 1968;90(5):905–11
  13. Nagai K, Ito Y, Otsuka N, Muranaka A, Kaji T, Terashima H, et al. Clinical usefulness on accumulation of 99mTc-rhenium colloid in lymph nodes [in Japanese]. Radioisotopes. 1980;29(11):549–51
  14. Nagai K, Ito Y, Otsuka N, Muranaka A. Deposition of small 99mTc-labelled colloids in bone marrow and lymph nodes. Eur J Nucl Med. 1982;7(2):66–70
  15. Ogawa Y, Hayashi K. 99mTc-DTPA-HSA lymphoscintigraphy in lymphedema of the lower extremities: diagnostic significance of dynamic study and muscular exercise [in Japanese]. Kaku Igaku. 1999;36(1):31–6
  16. Hung JC, Wiseman GA, Wahner HW, Mullan BP, Taggart TR, Dunn WL. Filtered technetium-99m-sulfur colloid evaluated for lymphoscintigraphy. J Nucl M