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Journals / Bozok Tıp Dergisi / 2015 / Cilt: 5 - Sayı: 2

Statin Related Rhabdomyolysis: Case Report

STATİNE BAĞLI RABDOMİYOLİZ: OLGU SUNUMU

Elif BÖREKÇİ
Zeynep TUğba ÖZDEMİR
Tekin YILDIRIM
Hüseyin EDE
Pages
75–79
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this article, to call attention to potentially life-threatening side effects of using combination of statin and fibrate derivatives, we reported a case of rhabdomyolysis developed by statin use.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Statins are safe drugs used frequently in the treatment of hyperlipidemia.
📊
Key Findings & Data:Statin related rhabdomyolysis is the worst and the mostly mentioned side effect of statins but very rarely seen.
💡
Conclusion & Impact:In this article, to call attention to potentially life-threatening side effects of using combination of statin and fibrate derivatives, we reported a case of rhabdomyolysis developed by statin use.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Statins are safe drugs used frequently in the treatment of hyperlipidemia. Statin related rhabdomyolysis is the worst and the mostly mentioned side effect of statins but very rarely seen. In this article, to call attention to potentially life-threatening side effects of using combination of statin and fibrate derivatives, we reported a case of rhabdomyolysis developed by statin use.

Özet

Statinler hipelipidemi tedavisinde sıklıkla kullanılan güvenilir ilaçlardır. Statine bağlı rabdo- miyoliz en çok korkulan ve en çok bahsedilen yan etki olmasına rağmen nadiren görülür. Bu yazıda, ciddi klinik sonuçlara yol açabilme potansiyeli nedeniyle, statin ve fibrat türev- lerinin birlikte kullanımına dikkat çekmek amacıyla, statine bağlı gelişen bir rabdomiyoliz olgusunu sunduk.

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Cite This Article

BÖREKÇİ, E., ÖZDEMİR, Z. T., YILDIRIM, T., EDE, H. (2022). Statin Related Rhabdomyolysis: Case Report. Bozok Tıp Dergisi, Cilt: 5 - Sayı: 2, 75–79. https://ajindex.com/articles/468904

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References (16)

  1. Melli G, Chaudhry V, Cornblath DR. Rhabdomyolysis: an evaluation of 475 hospitalized patients. Medicine (Baltimore). 2005;84(6):377-85
  2. Haas CE, Magram Y, Mishra A.Rhabdomyolysis and acute renal failure following an ethanol and diphenhidramine overdose. Ann Pharmacother. 2003;37(4):538-42
  3. Rodrigez ML, Mora C, Navaro JF.Cerivastatin-induced rhabdomyolisis. Ann Intem Med. 2000;132(7):598
  4. Unal A, Torun E, Sipahioglu MH, Tokgoz B, Kaya MG, Oymak O, et al. Fenofibrate-induced acute renal failure due to massive rhabdomyolysis after coadministration of statin in two patients. Inter Med. 2008;47(11):1017-9
  5. Schech S, Graham D, Staffa J, Andrade SE, La Grenade L, Burgess M, et al. Risk factors for statin-associated rhabdomyolysis. Pharmaco epidemiol Drug Saf. 2007;16(3):352-8
  6. Ireland JH, Eggert CH, Arendt CJ, Williams AW. Rhabdomyolysis with cardiac involvement and acute renal failure in a patient taking rosuvastatin and fenofibrate. Ann Intern Med. 2005;142(11):949-50
  7. Kursat S, Alici T, Colak HB. A case of rhabdomyolysis induced acute renal failure secondary to statin-fibrate- derivative combination and occult hypothyroidism. Clin Nephrol. 2005;64(5):391-3
  8. Graham DJ, Staffa JA, Shatin D, Andrade SE, Schech SD, La Grenade L, et al. Incidence of hospitalized rhabdomyolysis in patients treated with lipid-loweringdrugs. JAMA. 2004;292(21):2585-90
  9. Antos KA, Williams CD, Baker SK, Philiph PS. Clinical perspectives of statin-induced rhabdomyolysis. Am J Med. 2006;119(5):400-9
  10. Polderman KH. Acute renal failure and rhabdomyolysis. Int J Artif Organs. 2004;27(12):1030-3
  11. A. Grundy SM. Can statins cause chronic low-grade myopathy? Ann Intern Med. 2002;137(7):617-8
  12. Sathasivam S, Lecky B.Statin induced myopathy. BMJ. 2008;337:a2286
  13. Sathasivam S. Statin induced myotoxicity. Eur J InternMed. 2012;23(4):317-24
  14. Flint OP, Masters BA, Gregg RE, Durham SK. HMG CoA reductase inhibitor-induced myotoxicitiy; pravastatin and lovastatin inhibit the geranylgeranylation of low-molecular weight proteins in neonatal rat muscle cell culture. Toxicol Appl Pharmacol. 1997;145(1):99-110
  15. Gadbut AP, Caruso AP, Galper JB. Differential sensitivity of C2-C12 striated muscle cell stolovastatin and pravastatin. J Mol Cell Cardiol. 1995;27(10):2397-402
  16. Laaksonen R, Jokelainen K, Laakso J, Sahi T, Harkonen M, Tikkanen MJ, et al.The effect of simvastatin treatment on natural antioxidants in low density lipoproteins and high- energy phosphat