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Journals / Bozok Tıp Dergisi / 2016 / Cilt: 6 - Sayı: 3

Protective Effects of Hypericum Perforatum Oil on Indomethacin-induced Gastric Mucosal Damage

İNDOMETHAZİNE BAĞLI OLUŞAN GASTRİK MUKOZAL HASAR ÜZERİNE HYPERİCUM PERFORATUM YAĞININ KORUYUCU ETKİSİ

Mehmet Cengiz ÜSTÜNER
Cansu ÖZBAYER
Hülyam KURT
Dilek BURUKOĞLU
Tunç TUNCEL
İrfan DEĞİRMENCİ
Hasan Veysi GÜNEŞ
Selva Moheb SAADAT
Zeynep KÖROĞLU ÖZDEMIR
Pages
46–52
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Results: Ulcerative control group showed higher scores than control group which was treated with HPO (p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: In recent years, herbal products are rapidly increasing interest because of the adverse effects of chemical drugs.
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Key Findings & Data:Also, we aimed to investigate the healing and protective effects of Hypericum perforatum oil (HPO) on gastric mucosal injury in our study.Methods: In this study, male Sprague-Dawley rats were used. 1 hour before mucosal damage was induced, HPO (2 ml/kg) was added into the groups.
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Conclusion & Impact:Results: Ulcerative control group showed higher scores than control group which was treated with HPO (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: In recent years, herbal products are rapidly increasing interest because of the adverse effects of chemical drugs. Indomethacin is endol derivated non-steroidal anti-inflammatory drugs and widely used for induction of experimental ulcer model. Antioxidants may also play an important role in the prevention of mucosal damage. Hypericum perforatum L., commonly known as St John's wort is a traditional herb that has been used to treat many diseases. St John's wort extract has also effects as an anti-inflammatory, antimicrobial, wound healing, antioxidant, antineoplastic, antianxiety, antidepressant and anti-ulcerative effects. Also, we aimed to investigate the healing and protective effects of Hypericum perforatum oil (HPO) on gastric mucosal injury in our study.Methods: In this study, male Sprague-Dawley rats were used. 1 hour before mucosal damage was induced, HPO (2 ml/kg) was added into the groups. Mucosal damage is induced by intragastrically applying 30 mg/kg indomethacin. From samples of stomach, gastric pH, analysis of gastric mucus and ulcer index were calculated. In stomach homogenates SOD, MDA and CAT levels were determined. Results: Ulcerative control group showed higher scores than control group which was treated with HPO (p

Özet

Amaç: Son yıllarda kimyasal ilaçların yan etkilerine karşı bitkisel ürünlere olan ilgi hızla artmaktadır. İndol türevi bir non steroidal anti-inflamatuar ilaç olan indometazin ile deneysel ülser modeli oluşturmak yaygın bir yöntemdir. Antioksidanlar, mukozal hasarı önlenmesinde önemli bir rol oynayabilir. Anti-inflamatuar, antimikrobiyal, yara iyileşmesi, antioksidan, antineoplastik, antianksiyete, antidepresan ve anti ülseratif etkileri olan Sarı Kantaron olarak bilinen Hypericum perforatum L., halk arasında birçok hastalığın tedavisinde kullanılan geleneksel bir bitkidir. Bizde çalışmamız da Sarı Kantaron yağının gastrik mukozal iyileşme ve hasar önleyici etkisini araştırmayı planladık.Gereç ve yöntemler: Çalışmada, Sprague-Dawley erkek sıçanlar kullanıldı. Mukozal hasar indüklenmeden 1 saat önce Hypericum perforatum yağı (HPY) (2 ml/kg) olacak şekilde verildi. Mukozal hasar intragastrik olarak 30 mg/kg indometazin uygulaması ile oluşturuldu. Çalışmanın sonunda mide dokularında ülser alan indeksi, SOD, MDA ve KAT düzeyleri ölçülerek mide ince yapısı histopatolojik olarak değerlendirildi. Bulgular: Ülser skoru, kontrol grubu ve HPY ile tedavi edilen ülser grubunda, ülseratif kontrol grubunun göre anlamlı oranda düşüktü (p

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Cite This Article

ÜSTÜNER, M. C., ÖZBAYER, C., KURT, H., BURUKOĞLU, D., TUNCEL, T., DEĞİRMENCİ, İ., GÜNEŞ, H. V., SAADAT, S. M., ÖZDEMIR, Z. K. (2022). Protective Effects of Hypericum Perforatum Oil on Indomethacin-induced Gastric Mucosal Damage. Bozok Tıp Dergisi, Cilt: 6 - Sayı: 3, 46–52. https://ajindex.com/articles/468827

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References (14)

  1. Zdunic G, Go?evac D, Milenkovic M, Vucicevic D, Savikin K, Menkovic N, et al. Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats. Phytotherapy Research. 2009;23(11):1559-64
  2. Saddiqe Z, Naeem I, Maimoona A. A review of the antibacterial activity of Hypericum perforatum L. Journal of ethnopharmacology. 2010;131(3):511-21
  3. Huang N, Rizshsky L, Hauck C, Nikolau BJ, Murphy PA, Birt DF. Identification of anti-inflammatory constituents in Hypericum perforatum and Hypericum gentianoides extracts using RAW 264.7 mouse macrophages. Phytochemistry. 2011;72(16):2015-23
  4. Orcic DZ, Mimica-Dukic NM, Franciskovic MM, Petrovic SS, Jovin E?. Antioxidant activity relationship of phenolic compounds in Hypericum perforatum L. Chem Cent J. 2011;5(1):1- 8
  5. Süntar I, Akkol EK, Keleş H, Oktem A, Başer KHC, Yeşilada E. A novel wound healing ointment: a formulation of Hypericum perforatum oil and sage and oregano essential oils based on traditional Turkish knowledge. Journal of ethnopharmacology. 2011;134(1):89-96
  6. Olaleye S, Farombi E. Attenuation of indomethacin-and HCl/ethanol-induced oxidative gastric mucosa damage in rats by kolaviron, a natural biflavonoid of Garcinia kola seed. Phytotherapy Research. 2006;20(1):14-20
  7. Yoshikawa T, Naito Y, Kishi A, Tomii T, Kaneko T, Iinuma S, et al. Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats. Gut. 1993;34(6):732-7
  8. Demir S, Yilmaz M, Koseoglu M, Akalin N, Aslan D, Aydin A. Role of free radicals in peptic ulcer and gastritis. Turkish Journal of Gastroenterology. 2003;14(1):39-43
  9. Sun YI, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clinical chemistry. 1988;34(3):497- 500
  10. Goth L. Serum catalase: reversibly formed charge isoform of erythrocyte catalase. Clinical chemistry. 1991;37(12):2043- 7
  11. Uchiyama M, Mihara M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Analytical biochemistry. 1978;86(1):271-8
  12. Eminler AT, Uslan Mİ, Köksal AŞ, Parlak E. Non-Steroid Anti-İnflamatuvar İlaçların Üst Gastrointestinal Sistem Yan Etkileri ve Önlenmesi. 2014;18(3):333-8
  13. Öztürk N, Korkmaz S, Öztürk Y. Wound-healing activity of St. John's Wort (Hypericum perforatum L.) on chicken embryonic fibroblasts. Journal of ethnopharmacology. 2007;111(1):33-9
  14. Zobayed S, Saxena P. In vitro-grown roots: a su