AI Summary & Key Takeaways
AI InsightThe hematological results showed decreasing in Hemoglobin, Packed Cell Volume and platelets count; but the White Blood Cells were recorded increasing in their count with the increasing in concentrations and exposure period.
📌 3 Key Takeaways
Abstract
The most important goals of this study is screening effects of Diethanolamine (DEA) which is consider one of the most important ingredients in cosmetic products in some tissues of female albino mice (blood and liver) as laboratory models;(DEA) which using for neutralizing the pH through the industry of cosmetic product or adding to make the product fatty or more sudsy; and as a preservative in vegetables and meat, also in some Pharmaceutical preparations as one of the ingredients of medicine for patients of Pulmonary Arterial Hypertension (PHA); and in industry of intravenous solutions and preservative solution for contact lenses. Thirty mice at the average age of (40 days) and weight (21- 24 gm); were divided into 6 groups (control, 603, 1250, 2500, 5000, 10000 ppm), each group includes five mice were treated for two weeks; weight gain except the higher concentrations, ruffled fur, pale foot pads and abortions were recorded. Water consumption was increased in mice groups which treated with low concentrations and decreased in higher concentrations resulting in severe dehydration which cause death. The hematological results showed decreasing in Hemoglobin, Packed Cell Volume and platelets count; but the White Blood Cells were recorded increasing in their count with the increasing in concentrations and exposure period. Monocytes, Neutrophils and Lymphocytes were increased also because the decreasing immunity for mice. The histopathological sections showed the increasing in liver weight and showed hepatocytes degeneration, congestion of the central vein, sinusoid dilation, necrosis and lysis of hepatocytes, sever fatty changes, nuclear pyknosis and karyorrhexis and infiltration of inflammatory cells.