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Journals / Bitlis Eren Üniversitesi Fen Bilimleri Dergisi / 2020 / Cilt: 9 - Sayı: 2

In vivo Determination of Antioxidant Properties of Heterocyclic 4,5- dihydro-1H-1,2,4-triazole-5-one Derivative in Male Rats (Wistar albino)

Heterosiklik 4,5-dihidro-1H-1,2,4-triazol-5-on Türevinin Antioksidan Özelliğinin Erkek Ratlarda (Wistar albino) İn vivo Olarak Belirlenmesi

Haydar YÜKSEK
Murat BEYTUR
Onur AKYILDIRIM
Mustafa AKÇAY
Cansu BEYTUR
Evren KOÇ
Pages
542–548
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result of the spectrophotometric analyzes, total antioxidant status (TAS) were increased in the serum treated groups of both 3- MTA compounds (P

📌 3 Key Takeaways

🎯
Objective & Hypothesis:4,5-Dihydro-1H-1,2,4-triazol-5-one derived heterocyclic compounds have an important place in industry, medicine, pharmacy and many other fields of chemistry.
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Key Findings & Data:One of these activities is the antioxidant property of 1,2,4-triazol-5-one derivatives.
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Conclusion & Impact:As a result of the spectrophotometric analyzes, total antioxidant status (TAS) were increased in the serum treated groups of both 3- MTA compounds (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

4,5-Dihydro-1H-1,2,4-triazol-5-one derived heterocyclic compounds have an important place in industry, medicine, pharmacy and many other fields of chemistry. Biological activity properties of these compounds have been examined in vitro, it was determined that some of them show high activity. One of these activities is the antioxidant property of 1,2,4-triazol-5-one derivatives. In the present study, the antioxidant properties of 3-methyl4-(3,4-dihydroxybenzylideneamino)-4,5-dihydro-1H-1,2,4-triazol-5-one (3-MTA) were determined in rats by spectrophotometric method in vivo. For this purpose, animals were divided into 4 groups; control group, dimethyl sulfoxide (DMSO) group, 10 mg/kg and 50 mg/kg including MTA compound groups. As a result of the spectrophotometric analyzes, total antioxidant status (TAS) were increased in the serum treated groups of both 3- MTA compounds (P

Özet

4,5-Dihidro-1H-1,2,4-triazol-5-on türevli heterosiklik bileşikler sanayide, tıpta, eczacılıkta ve kimyanın pek çokalanında önemli yere sahiptir. Bu bileşiklerin bazı biyolojik aktivite özellikleri in vitro olarak incelenmiş olupbazılarının yüksek aktivite gösterdikleri belirlenmiştir. Bu aktivitelerden biri de 1,2,4-triazol-5-on türevleriningöstermiş olduğu antioksidan özelliğidir. Mevcut araştırmada da, 3-metil-4-(3,4-dihidroksibenzilidenamino)-4,5-dihidro-1H-1,2,4-triazol-5-on (3-MTA) bileşiğinin antioksidan özellik gösterip göstermediği ratlarda in vivoolarak spektrofotometrik yöntemle belirlenmiştir. Bu amaçla hayvanlar; kontrol grubu, dimetil sülfoksit (DMSO)grubu, 10 mg/kg ve 50 mg/kg 3-MTA bileşiği içeren gruplar olacak şekilde 4’e ayrılmıştır. Yapılanspektrofotometrik analizler neticesinde kontrol grubuna kıyasla serumda 10 ve 50 mg/kg dozunda 3-MTA bileşiğiuygulanan gruplarda (P

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Cite This Article

YÜKSEK, H., BEYTUR, M., AKYILDIRIM, O., AKÇAY, M., BEYTUR, C., KOÇ, E. (2022). In vivo Determination of Antioxidant Properties of Heterocyclic 4,5- dihydro-1H-1,2,4-triazole-5-one Derivative in Male Rats (Wistar albino). Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, Cilt: 9 - Sayı: 2, 542–548. https://ajindex.com/articles/466821

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References (8)

  1. Atashi F., Modarressi A., Pepper M.S. 2015. The Role of Reactive Oxygen Species in Mesenchymal Stem Cell Adipogenic and Osteogenic Differentiation: A Review. Stem Cells and Development, 24 (10): 1150-1163
  2. Ihsan A.U., Khan F.U., Khongorzul P., Ahmad K.A., Naveed M., Yasmeen S., Cao Y., Taleb A., Maiti R., Akhter F. 2018. Role of Oxidative Stress in Pathology of Chronic Prostatitis/Chronic Pelvic Pain Syndrome and Male Infertility and Antioxidants Function in Ameliorating Oxidative Stress. Biomedicine & Pharmacotherapy, 106: 714-723
  3. Pillai R.R., Karrouchi K., Fettach S., Armaković S., Armaković S.J., Brik Y., Taoufik J., Radi S., Faouzi M.E.A., Ansar M. 2019. Synthesis, Spectroscopic Characterization, Reactive Properties by DFT Calculations, Molecular Dynamics Simulations and Biological Evaluation of Schiff Bases Tethered 1,2,4-Triazole and Pyrazole Rings. Journal of Molecular Structure, 1177: 47-54. [4] Đorović J., Milenković D., Joksović L., Joksović M., Marković Z. 2019. Study of Influence of Free Radical Species on Antioxidant Activity of Selected 1,2,4‐triazole‐3‐thiones. Chemistry Select, 4 (25): 7476-7485
  4. Ibrahim M.Y., Hashim N.M., Dhiyaaldeen S.M., Al-Obaidi M.M.J., El-Ferjani R.M., Adam H., Alkotaini B., Al Batran R., Ali H.M. 2016. Acute Toxicity and Gastroprotection Studies of A New Schiff Base Derived Manganese(II) Complex Against Hcl/Ethanol-Induced Gastric Ulcerations in Rats. Scientific Reports, 6: 26819
  5. Kahveci B., Özil M., Menteşe E., Bekircan O., Buruk K. 2008. Microwave-Assisted Synthesis and Antifungal Activity of Some New 1H-1,2,4-triazole Derivatives. Russian Journal of Organic Chemistry, 44 (12): 1816-1820
  6. Demirbaş N., Ug̵urluog̵lu R., Demirbaş A. 2002. Synthesis of 3-alkyl(aryl)-4-alkylidenamino-4, 5-dihydro-1H-1,2,4-triazol-5-ones and 3-alkyl-4-alkylamino-4,5-dihydro-1H-1,2,4-triazol-5- ones as Antitumor Agents. Bioorganic & Medicinal Chemistry, 10 (12): 3717-3723
  7. Saini K.S., Ajay A., Devender N., Bhattacharjee A., Das S., Dwivedi S., Gupt M.P., Bora H.K., Mitra K., Tripathi R.P. 2015. Triazole Analog 1-(1-benzyl-5-(4-chlorophenyl)-1H-1,2,3-triazol4-yl)-2-(4-bromophenylamino)-1-(4-chlorophenyl) Ethanol Induces Reactive Oxygen Species and Autophagy-Dependent Apoptosis in both In vitro and In vivo Breast Cancer Models. The International Journal of Biochemistry & Cell Biology, 65: 275-287
  8. Arslantas A., Yüksek H., Gürsoy Kol Ö., Ocak Z., Tomruk Z., Calapoglu M. 2012. Study of Antioxidant Properties