A single dose PTZ 80 mg/kg i.p. was administered and seizures were observed and evaluated with regard to latency, frequency and stage for one hour.Results: Seizure frequen cy after PTZ administration was significantly decreased in LUT pretreated rats (p
📌 3 Key Takeaways
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Objective & Hypothesis:Objective: Flavonoids are an important group of recognized antioxidants in plants.
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Key Findings & Data:This study was aimed to investigate the effects of the LUT in the liver, kidney and brain of pentylentetrazol (PTZ)-induced seizure and the relationship between nitric oxide synthases (iNOS, eNOS) and matrix metalloproteinases (MMP2, MMP9).Materials and Methods: LUT (10 mg/kg) was given intraperitoneally during two weeks prior to seizure induction.
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Conclusion & Impact:A single dose PTZ 80 mg/kg i.p. was administered and seizures were observed and evaluated with regard to latency, frequency and stage for one hour.Results: Seizure frequen cy after PTZ administration was significantly decreased in LUT pretreated rats (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Objective: Flavonoids are an important group of recognized antioxidants in plants. Luteolin (LUT) is a natural flavonoid in the plant kingdom. This study was aimed to investigate the effects of the LUT in the liver, kidney and brain of pentylentetrazol (PTZ)-induced seizure and the relationship between nitric oxide synthases (iNOS, eNOS) and matrix metalloproteinases (MMP2, MMP9).Materials and Methods: LUT (10 mg/kg) was given intraperitoneally during two weeks prior to seizure induction. A single dose PTZ 80 mg/kg i.p. was administered and seizures were observed and evaluated with regard to latency, frequency and stage for one hour.Results: Seizure frequen cy after PTZ administration was significantly decreased in LUT pretreated rats (p
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Cite This Article
KAPUCU, A., ÜZÜM, G., AKGÜN, K. D., ACAR, S., BİRMAN, H. (2022). Effects of luteolin on liver, kidney and brain in pentylentetrazol-induced seizures: Involvement of metalloproteinases and NOS activities. Balkan Medical Journal, Cilt: 29 - Sayı: 2, 188–196. https://ajindex.com/articles/461700
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